CARD18 / ICEBERG antibody

Principal name

CARD18 / ICEBERG antibody

Alternative names for CARD18 / ICEBERG antibody

Caspase recruitment domain-containing protein 18, Caspase-1 inhibitor Iceberg

SwissProt ID

P57730 (Human)

Gene ID

59082 (CARD18)

Available reactivities

Hu (Human), Rt (Rat)

Available hosts

Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB)

Background of CARD18 / ICEBERG antibody

A novel protein, ICEBERG, an inhibitor of pro-caspase 1 activation, has been studied. It consists essentially only of a CARD, inhibits generation of IL-1b by interacting with caspase-1 and preventing association with RIP 2. The ICEBERG functions as a competitive antagonist of RIP 2/pro-caspase 1 interactions and inhibits caspase 1 dependent pro-L-1b secretion in mononuclear cells. ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop.

General readings

General / background references:Razmara M et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem 277:13952-8 (2002). PubMed PMID: 11821383
Druilhe A et al. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ 8:649-57 (2001). PubMed PMID: 11536016
Lee SH et al. Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. J Biol Chem 276:34495-500 (2001). PubMed PMID: 11432859
Humke EW et al. ICEBERG: a novel inhibitor of interleukin-1beta generation. Cell 103:99-111 (2000). PubMed PMID: 11051551

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CARD18 / ICEBERG antibody

CARD18 / ICEBERG Goat IgG Aff - Purified Hu WB
50 µg / €400.00
  Novus Biologicals Inc.

CARD18 / ICEBERG antibody

CARD18 / ICEBERG Rabbit IgG Aff - Purified Hu, Rt E, WB
50 µg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CARD18 / ICEBERG

CARD18 / ICEBERG Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CARD18 / ICEBERG (1-90, His-tag)

CARD18 / ICEBERG Human Purified > 95 % by SDS - PAGE E. coli
0.25 mg / €940.00
  Acris Antibodies GmbH

CARD18 / ICEBERG (1-90, His-tag)

CARD18 / ICEBERG Human Purified > 95 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

CARD18 / ICEBERG

CARD18 / ICEBERG Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CARD18 / ICEBERG

CARD18 / ICEBERG Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

CARD18 / ICEBERG

CARD18 / ICEBERG Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CARD18 / ICEBERG

CARD18 / ICEBERG Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CARD18 overexpression lysate

CARD18 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

ICEBERG 293T Cell Transient Overexpression Lysate(Denatured)

ICEBERG 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

11 Item(s)

per page
  • LinkedIn