CARD4 / NOD1 antibody

Principal name

CARD4 / NOD1 antibody

Alternative names for CARD4 / NOD1 antibody

Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4

SwissProt ID

Q8BHB0 (Mouse), Q9Y239 (Human)

Gene ID

10392 (NOD1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CARD4 / NOD1 antibody

Innate immunity is present in all animals and is the common mode of defense against microorganisms. It detects microorganisms by specific proteins called pattern-recognition molecules (PRMs) (reviewed in Werts et al. 2006). There is a limited set of PRMs in each animal genome, and it has been postulated that the PRMs were evolutionarily selected to detect conserved components or motifs of microorganisms called pathogen-associated molecular patterns (PAMPs). PAMPs are found in a wide range of microorganisms and recognition of PAMPs by PRMs activates inflammatory signaling pathways, thereby stimulating an immune response. NOD (nucleotide-binding oligomerization domain) proteins are a family of cytosolic proteins which have been implicated in innate recognition of bacteria, the induction of inflammatory responses, and the regulation of caspase activation and apoptosis. NOD1/CARD4 (caspase-recruitment domain 4 gene) is a PRM that recognizes specific peptidoglycan (PGN) components of bacterial cell walls (reviewed in Strober et al. 2006, and Inohara et al. 2003). NOD1 is expressed by cell types that are exposed to PGN under physiological conditions including antigen-presenting cells (APCs) such as macrophages and dendritic cells, and epithelial cells (reviewed in Strober et al. 2006). NOD1 is thought to play a role in the pathogenesis of human gastrointestinal disease and is associated with inflammatory bowel diseases and asthma. It is involved in host defense against Helicobacter pylori infection of the gastric mucosa, a chronic infection that can lead to peptic ulcers and gastric cancer. This antibody recognizes NOD1/CARD4. Human NOD1/CARD4 is a 953 amino acid protein.

General readings

1. Bertin, J., Nir, W.-J., Fischer, C. M., Tayber, O. V., Errada, P. R., Grant, J. R., Keilty, J. J., Gosselin, M. L., Robison, K. E., Wong, G. H. W., Glucksmann, M. A., DiStefano, P. S. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappa-B.
J. Biol. Chem. 274: 12955-12958, 1999. PMID: 10224040

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CARD4 / NOD1 antibody

Western blot analysis of Mouse bladder cell lysate using NOD1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 antibody

Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. TA308671 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 (C-term) antibody

(0.5ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 (C-term) antibody

Western blot analysis of NOD1 in EL4 cell lysate with NOD1 antibody at 1 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 (C-term) antibody

AP17920PU-N CARD4 antibody staining of Formalin-Fixed, Paraffin-Embedded Human skeletal muscle tissue. This  Antibody was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CARD4 / NOD1 Control Peptide

CARD4 / NOD1
50 µg / €160.00
  Acris Antibodies GmbH

CARD4 / NOD1 (C-term) antibody

Human Small Intestine, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CARD4 / NOD1 antibody

CARD4 / NOD1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CARD4 / NOD1 antibody

Western Blot analysis of NOD1 expression in transfected 293T cell line (H00010392-T01) by NOD1 MaxPab polyclonal antibody.

Lane 1: CARD4 transfected lysate(104.83 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CARD4 / NOD1 antibody

Western Blot analysis of NOD1 expression in transfected 293T cell line (H00010392-T02) by NOD1 MaxPab polyclonal antibody.

Lane 1: NOD1 transfected lysate(107.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CARD4 / NOD1 antibody

CARD4 / NOD1 Mouse IgG2b 3F10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CARD4 / NOD1 antibody

Formalin-fixed, paraffin-embedded sections of human colon ( A, A1 ) and pancreas ( B, B1 ) stained for NOD1 expression. NOD1 polyclonal antibody ( Cat # PAB0266 ) at 1 : 2000. Using a DAB chromogen and Hematoxylin counterstain. Magnification : A ( 20X ) , A1 ( 40X ) . B ( 10X ) , B1 ( 40X ) . Rabbit Hu C, IP, P
50 µl / €400.00
  Abnova Taiwan Corp.

CARD4 / NOD1 antibody

Detection of NOD1 ( human ) in HEK 293T transfected cells with NOD1 polyclonal antibody ( Cat # PAB13791 ). 10 µg per lane of total cell extracts from mock transfected HEK 293T cells ( lane 1 ) or HEK 293T cells transfected with a plasmid coding for human NOD1 ( lane 2 ). Rabbit Hu WB
50 µg / €560.00
  Abnova Taiwan Corp.

CARD4 / NOD1 antibody

Immunofluorescence: NOD1 Antibody [NBP1-31349] - Immunofluorescence analysis of HeLa, using NBP1-31349 at 1:200 dilution. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CARD4 / NOD1 antibody

CARD4 / NOD1 Goat Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CARD4 / NOD1 antibody

Western Blot: NOD1 Antibody [NBP1-76286] - Analysis of NOD1 in EL4 cell lysate with NOD1 antibody at 1 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CARD4 / NOD1

CARD4 / NOD1 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

CARD4 / NOD1

CARD4 / NOD1 Human
10 µg / €380.00
  Abnova Taiwan Corp.

CARD4 / NOD1

CARD4 / NOD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CARD4 / NOD1

CARD4 / NOD1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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