CARD4 / NOD1 antibody

Principal name

CARD4 / NOD1 antibody

Alternative names for CARD4 / NOD1 antibody

Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4

SwissProt ID

Q8BHB0 (Mouse), Q9Y239 (Human)

Gene ID

10392 (NOD1), 107607 (Nod1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CARD4 / NOD1 antibody

Nod1/CARD4 is a cytosolic protein structually related to Apaf-1 and plant drug-resistance proteins that has been implicated in apoptosis and inflammatory responses to certain pathogenic bacteria. It contains an amino-termil caspase recruitment domain (CARD) that is linked to a central nucleotide-binding domain (NBD; also known as a NOD domain) and is followed by carboxy-termil leucine-rich repeats (LRR). Like Apaf-1, Nod1 induces apoptosis by a CARD/NBD-dependent activation of caspase-9. The primary function of Nod1 is thought to be as a sensor for certain pathogenic microbes and triggering inflammatory responses including the activation of NF-¦ÊB and JNK pathways. The LRR of Nod1 appears to be involved in recognition of microbial components and the CARD domain induces NF-¦ÊB activation in cooperation with the CARD containing kise, RICK/RIP2/CARDIAK. Mutations in Nod1 have been linked increased susceptibility to asthma and inflammatory bowel disease.

General readings

1. Bertin, J., Nir, W.-J., Fischer, C. M., Tayber, O. V., Errada, P. R., Grant, J. R., Keilty, J. J., Gosselin, M. L., Robison, K. E., Wong, G. H. W., Glucksmann, M. A., DiStefano, P. S. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappa-B.
J. Biol. Chem. 274: 12955-12958, 1999. PMID: 10224040

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CARD4 / NOD1 antibody

  Rabbit anti-NOD1 Polyclonal Antibody  
Western blot analysis of Mouse bladder cell lysate using NOD1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 antibody

  Rabbit polyclonal antibody to NOD1 (nucleotide-binding oligomerization domain containing 1)  
Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. TA308671 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 (C-term) antibody

  Goat Anti-NOD1 / CARD4 Antibody  
(0.5ug/ml) staining of Human Duodenum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 (C-term) antibody

  Rabbit Polyclonal Anti-NOD1 Antibody  
Western blot analysis of NOD1 in EL4 cell lysate with NOD1 antibody at 1 ug/mL. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 antibody

  Rabbit Polyclonal Anti-NOD1 Antibody  
CARD4 / NOD1 Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 antibody

  Mouse Monoclonal anti-NOD1 Antibody  
293E cells untransfected (lane 1) or 293E transfected with hNOD1(lane 2) were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified anti-NOD1(U54-014) antibody. Proteins were visualized using an anti-mouse-IgG secondary conjugated to HRP and chemiluminescence detection. Mouse U54-014 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CARD4 / NOD1 (C-term) antibody

AP17920PU-N CARD4 antibody staining of Formalin-Fixed, Paraffin-Embedded Human skeletal muscle tissue. This  Antibody was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CARD4 / NOD1 (C-term) antibody

Human Small Intestine, Submucosal Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

NOD1 - human gene knockout kit via CRISPR

NOD1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

NOD1 - human gene knockout kit via CRISPR

NOD1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOD1 - human gene knockout kit via CRISPR

NOD1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

NOD1 - human gene knockout kit via CRISPR

NOD1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nod1 - mouse gene knockout kit via CRISPR

Nod1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Nod1 - mouse gene knockout kit via CRISPR

Nod1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nod1 - mouse gene knockout kit via CRISPR

Nod1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Nod1 - mouse gene knockout kit via CRISPR

Nod1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Nod1 (GFP-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Nod1 (GFP-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,710.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nod1 (GFP-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Nod1 (GFP-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,390.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nod1 (Myc-DDK-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Nod1 (Myc-DDK-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,540.00
  OriGene Technologies, Inc.

Lenti ORF particles, Nod1 (Myc-DDK-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Nod1 (Myc-DDK-tagged) - Mouse nucleotide-binding oligomerization domain containing 1 (Nod1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,250.00
  OriGene Technologies, Inc.

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