Cardiotrophin-1 antibody

Principal name

Cardiotrophin-1 antibody

Alternative names for Cardiotrophin-1 antibody

CT-1, CTF1

SwissProt ID

Q16619 (Human), Q60753 (Mouse), Q63086 (Rat)

Gene ID

1489 (CTF1), 13019 (Ctf1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Mky (Monkey), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Functional assay (FN), ELISA (detection) (E(detection)), Paraffin Sections (P), Neutralisation (NEUT)

Background of Cardiotrophin-1 antibody

Cardiotrophin-1 (CT-1) is a 201 amino acid member of the interleukin-6 superfamily. It was identified by its ability to induce hypertrophic response in cardiac myocytes. CT-1 mRNA levels were found both in cardiac myocytes and in cardiac nonmyocytes. CT-1 was also detected in abundance in normal adult human lung and was expressed in both fetal and adult airway smooth muscle cells. CT-1activates gp130 dependent signaling and stimulates the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway to transduce hypertrophic and cytoprotective signals in cardiac myocytes. CT-1 has also a neurotrophic function. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice during a period between embryonic day 14 and the first postnatal week. Moreover, CT-1 is a hepatocyte survival factor that efficiently reduces hepatocellular damage in animal models of acute liver injury. CT-1 expression is augmented after hypoxic stimulation and it can protect cardiac cells when added either prior to simulated ischaemia or at the time of reoxygenation following simulated ischaemia. CT-1 can induce expression of the protective heat shock proteins (hsps) in cardiac cells. Cardiotrophin-1 increased ventricular expression of ANP, brain natriuretic peptide (BNP) and angiotensinogen mRNA. CT-1 levels were significantly elevated in patients with heart failure, patients with dilatative cardiomyopathy, moderate/severe mitral regurgitation, stable and unstable angina and after acute myocardial infarction.
Total 212 AA. MW: 22.5 kDa (calculated). N-Terminal His-tag, 12 extra AA (highlighted).

General readings

Yu,M., (2008) Exp. Dermatol. 17 (1), 12-19

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cardiotrophin-1 antibody

Western blot analysis using recombinant human CT-1. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cardiotrophin-1 antibody

To detect hCardiotrophin-1 by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant hCardiotrophin-1. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cardiotrophin-1 antibody

To detect hCT-1 by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human CT-1 (TA328275) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hCT-1. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cardiotrophin-1 antibody

WB Suggested Anti-CTF1 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cardiotrophin-1 antibody

WB Suggested Anti-CTF1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: 721_B cell lysate CTF1 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cardiotrophin-1 antibody

Immunohistochemistry (IHC) analyzes of Cardiotrophin-1 antibody (Cat.-No.: AP20766PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cardiotrophin-1 (C-term) antibody

Western blot analysis of Cardiotrophin-1 Antibody (C-term) Cat.-No AP51121PU-N in K562 cell line lysates (35ug/lane). This demonstrates the CTF1 antibody detected the CTF1 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Cardiotrophin-1 Mouse IgG1 3G6D9 Purified Hu E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Cardiotrophin-1 Rabbit Aff - Purified Hu E, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Cardiotrophin-1 Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Cardiotrophin-1 Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Cardiotrophin-1 Rabbit Aff - Purified Hu E, FN, WB
50 µg / €230.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Cardiotrophin-1 Rabbit Aff - Purified Hu E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Cardiotrophin-1 antibody

Western Blot analysis of CTF1 expression in transfected 293T cell line (H00001489-T01) by CTF1 MaxPab polyclonal antibody.

Lane 1: CTF1 transfected lysate(22.11 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Cardiotrophin-1 antibody

Western Blot analysis of CTF1 expression in transfected 293T cell line (H00001489-T02) by CTF1 MaxPab polyclonal antibody.

Lane 1: CTF1 transfected lysate(21.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Cardiotrophin-1 antibody

Hum. Fetal Liver; Host: Rabbit . Target Name: CTF1 . Sample Tissue: Human Fetal Liver . Antibody Dilution: 1.0ug/ml.; CTF1 antibody - N-terminal region (ARP51943_P050) in Hum. Fetal Liver cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Cardiotrophin-1 (N-term) antibody

Cardiotrophin-1 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Cardiotrophin-1 antibody

Immunohistochemical analysis of Cardiotrophin-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Cardiotrophin-1 antibody

Immunohistochemical analysis of Cardiotrophin-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Cardiotrophin-1 antibody

Immunohistochemical analysis of Cardiotrophin-1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Mky, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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