CASK antibody

Principal name

CASK antibody

Alternative names for CASK antibody

Lin-2 homolog, LIN2, Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase

SwissProt ID

O14936 (Human), O70589 (Mouse), Q62915 (Rat)

Gene ID

29647 (Cask), 8573 (CASK), 12361

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Xen (Xenopus), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CASK antibody

CASK (calmodulin sensitive kinase) is a ~112kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures (1). While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator.
Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births. CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing.

General readings

Dimitratos SD, Woods DF, and Bryant PJ. Camguk, Lin-2, and CASK: novel membrane associated guanylate kinase homologs that also contain CaM kinase domains. Mech. Dev. 1997; 63:127-30.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CASK antibody

  Rabbit anti-CASK Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CASK antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CASK (C-term) antibody

  Rabbit Polyclonal Antibody against CASK (C-term)  
Western blot analysis of CASK (arrow) using Cask Antibody (C-term) (Cat.#TA302217). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CASK gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu, Ms P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CASK antibody

  Rabbit polyclonal Rat Cask Antibody (Center)  
Rat Cask Antibody (Center) (Cat. #TA325180) western blot analysis in rat brain tissue lysates (35ug/lane).This demonstrates the Rat Cask antibody detected the Rat Cask protein (arrow). Rabbit IgG Purified Hu, Ms, Rt WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CASK antibody

  Mouse Monoclonal Anti-CASK Antibody  
Western blot analysis on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S56A-50 Purified Hu, Ms, Rt, Xen, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CASK (N-term) antibody

  Rabbit Polyclonal CASK Antibody  
Western blot analysis of CASK in mouse brain tissue lysate with CASK antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CASK antibody

Adult rat brain immunohistochemistry Mouse IgG1 K56A/50 Supernatant Hu, Ms, Rt, Xen, Ze C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CASK antibody

Adult rat brain immunohistochemistry Mouse IgG1 K56A/50 Purified Hu, Ms, Rt, Xen, Ze C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CASK (318-415) antibody

CASK Mouse IgG1 S56A-50 Purified Hu, Ms, Rt, Xen, Ze C, ICC/IF, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CASK antibody

CASK Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CASK antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with CASK polyclonal antibody ( Cat # PAB2776 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CRISPR

Catalog No. Species Donor Vector  

CASK - human gene knockout kit via CRISPR

CASK - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CASK - human gene knockout kit via CRISPR

CASK - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CASK - human gene knockout kit via CRISPR

CASK - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CASK - human gene knockout kit via CRISPR

CASK - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cask - mouse gene knockout kit via CRISPR

Cask - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cask - mouse gene knockout kit via CRISPR

Cask - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cask - mouse gene knockout kit via CRISPR

Cask - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cask - mouse gene knockout kit via CRISPR

Cask - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CASK (transcript variant 1)

  Recombinant protein of human calcium/calmodulin-dependent serine protein kinase (MAGUK family) (CASK), transcript variant 1  
CASK Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CASK overexpression lysate

CASK overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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