Caspase-1 antibody

Principal name

Caspase-1 antibody

Alternative names for Caspase-1 antibody

CASP-1, CASP1, IL1BC, IL1BCE, ICE, p45, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme

SwissProt ID

P29452 (Mouse), P29466 (Human), P43527 (Rat), P89116 (Spofr), Q9MZV7 (Canfa)

Gene ID

834 (CASP1), 12362 (Casp1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse, Rat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)

Background of Caspase-1 antibody

Caspase-1, or interleukin-1ß converting enzyme (ICE/ICEa), is a class I cysteine protease, which also includes caspases -4, -5, -11, and -12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1ß and interferon-? inducing factor (IL-18) into their mature forms . Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-termil pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis . Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in the maturation of pro-IL-1ß and are resistant to endotoxic shock . At least six caspase-1 isoforms have been identified, including caspase-1 a, ß, ?, d, e and ? . Most caspase-1 isoforms (a, ß, ? and d) produce products between 30-48 kDa and induce apoptosis upon over-expression. Caspase-1 e typically contains only the p10 subunit, does not induce apoptosis and may act as a domint negative. The widely expressed ? isoform of caspase-1 induces apoptosis and lacks 39 amino-termil residues found in the a isoform (6). Activation of caspase-1 occurs through an oligomerization molecular platform desigted the "inflammasome" that includes caspase-5, Pycard/Asc, and LP1 .

General readings

Enari et al. Nature 375: 78, 1995.
Walker et al. Cell 78: 343, 1994.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-1 antibody

Western blot analysis of Caspase-1 expression in Rat liver tissue lysate using Caspase-1 Antibody Cat.-No AP00006PU-N Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Caspase-1 antibody

  Mouse Monoclonal Caspase-1 Antibody (14F468)  
Western Blot: Caspase 1 Antibody (14F468) [TA336409] - analysis of Caspase-1 using a Caspase-1 monoclonal antibody. Human HeLa (A) and mouse NIH3T3 lysate probed with Caspase-1 antibody at 0.5 ug/ml and 2 ug/ml, respectively. Mouse IgG1 14F468 Purified Hu, Ms C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 (C-term) antibody

  Rabbit Polyclonal Caspase-1 Antibody  
Western blot analysis of Caspase-1 in human heart cell lysate with Caspase-1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit Polyclonal Caspase-1 Antibody  
Western blot analysis of Caspase-1 in HeLa cell lysate with Caspase-1 antibody (IN) at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit polyclonal Caspase 1 (Cleaved-Asp210) antibody  
Western blot analysis of extracts from K562 cells and HepG2 cells, using Caspase 1 (Cleaved-Asp210) antibody (#TA312620).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit polyclonal Caspase 1 (Cleaved-Asp210) antibody  
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 1 (Cleaved-Asp210) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit polyclonal CASP1 (p20, Cleaved-Asn120) antibody  
Western blot analysis of extracts from rat eye cells, using CASP1 (p20, Cleaved-Asn120) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit polyclonal Caspase 1 (p10, Cleaved-Ala317) antibody  
Western blot analysis of extracts from COS7 cells, using Caspase 1 (p10, Cleaved-Ala317) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit polyclonal Caspase 1 (Ser376) antibody(Phospho-specific)  
Western blot analysis of extracts from 293 cells, using Caspase 1 (Phospho-Ser376) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Anti-CASP1 Rabbit Polyclonal Antibody  
Western blot analysis of Hela cell using TA323203(CASP1 Antibody) at dilution 1/150 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Anti-CASP1 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm . Positive control: Human pancreatic cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human pancreatic cancer tissue using CASP1 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  CASP1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CASP1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit Polyclonal Caspase-1 Antibody  
Western Blot: Caspase 1 Antibody [TA336408] - analysis of Caspase-1 using a polyclonal antibody. Human HeLa lysate probed with Caspase-1 antibody at 0.5 ug/ml. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit Polyclonal Anti-Caspase 1 Antibody  
Western blot analysis of Caspase 1 expression in 293 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit Polyclonal Anti-Caspase 1 (Phospho-Ser376) Antibody  
Western blot analysis of Caspase 1 (Phospho-Ser376) expression in 293 cells Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

  Rabbit Polyclonal anti-Caspase-1 Antibody  
Human Placenta stained with anti-Caspase-1 antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-1 antibody

Western Blot analysis: MCF7 (Lane 1) and Jurkat (Lane 2) cell extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-Capsase-1 Antibody Cat.-No AM33084PU (Clone 5B10). Proteins were visualized using a goat anti-rat secondary antibody conjugated to HRP and a chemiluminescence system. Rat IgG2a 5B10 Purified Hu P, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Caspase-1 antibody

Western Blot analysis: MCF7 (Lane 1) and Jurkat (Lane 2) cell extracts were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-Capsase-1 Antibody Cat.-No AM33084PU (Clone 5B10). Proteins were visualized using a goat anti-rat secondary antibody conjugated to HRP and a chemiluminescence system. Rat IgG2a 5B10 Purified Hu P, WB
25 µg / €240.00
  Acris Antibodies GmbH

Caspase-1 Control Peptide

Caspase-1 Purified
50 µg / €190.00
  Acris Antibodies GmbH

Caspase-1 antibody

Immunohistochemistry (IHC) analyzes of Caspase 1 antibody (Cat.-No.: AP06610PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

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