Caspase-10 antibody

Principal name

Caspase-10 antibody

Alternative names for Caspase-10 antibody

CASP-10, CASP10, MCH4, FLICE2, ICE-like apoptotic protease 4, Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2

SwissProt ID

Q92851 (Human)

Gene ID

843 (CASP10)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C)

Background of Caspase-10 antibody

Caspases are a family of intracellular proteases that mediate cell death and are the principal effectors of apoptosis. Caspase 10 (Mch4, ICE-LAP4, FLICE2) plays an important role in apoptosis induced by a variety of inducers such as TNF alpha and Anti-Fas antibody. It is a large prodomain caspase classified together with caspases 2, 8, and 9 as a signaling caspase. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomain, have been described. Caspase 10 contains two death domains (DED) involved in linking to the death effector domain of the adapter protein FADD and recruiting the complex to TNFR1 and Fas. The inactive procaspase 10 is variably expressed in many tissues and cell lines as a cytosolic protein. The mature form of caspase 10 comprises two subunits, p23/p17 (splice isoforms) and p12. Interestingly, a caspase 9- dependent processing of caspase 10 by caspase 6 in cell-free extracts has recently been suggested. Caspase 10 can cleave and activate caspases 3, 4, 6, 7, 8, and 9. This is followed by cleavage of numerous key proteins, including the nuclear protein PARP.

General readings

Ng P.W., Porter A.G., and Janicke R.U. J Biol Chem 1999 Apr 9;274(15):10301-8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-10 antibody

Western blot analysis of extracts from HeLa cells, using Caspase 10 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-10 antibody

Immunohistochemistry: Pro-Caspase-10 Antibody (E35) [NB110-55654] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma using anti-Caspase 10 Rabbit IgG E35 Purified Hu, Ms F, ICC/IF, IP, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Caspase-10 (C-term) antibody

AP15392PU Caspase-10 antibody staining of Human Liver Carcinoma. Rabbit Purified Hu P
0.5 ml / €410.00
  Acris Antibodies GmbH

Caspase-10 (C-term) antibody

AP15392PU Caspase-10 antibody staining of Human Liver Carcinoma. Rabbit Purified Hu P
1 ml / €580.00
  Acris Antibodies GmbH

Caspase-10 (C-term) antibody

AP15392PU Caspase-10 antibody staining of Human Liver Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Caspase-10 (C-term) antibody

Western blot analysis of caspase-10 in HeLa (H), Jurkat (J), A431 (A), K562 (K) whole cell lysates with Caspase-10 antibody at 1 µg/ml. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-10 antibody

Gel: 10%SDS-PAGE, Lysate: 30 µg, Lane: Human liver cancer tissue, Primary antibody: CASP10 Antibody at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 minutes Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-10 antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using CASP10 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-10 antibody

Western blot analysis of Hela (lane 1), Jurkat (lane 2) and NIH3T3 (lane 3) cells using anti-caspase-10 antibody (clone 25C2). β-actin antibody (poly6221) was used as loading control. Rat IgG2a 25C2 Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-10 antibody

Western Blot: Caspase 10 Antibody [TA336663] - WB detection of Caspase-10 in Jurkat cells using TA336663 at a dilution of 1:500. Before making the lysates, the cells were treated with 2 uM staurosporine for different time periods as shown in the image. Rabbit Purified Chk, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-10 antibody

Western blot analysis on HeLa cell lysate using Caspase 10 Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-10 (full length) antibody

Western blot analysis of Caspase-10 fragments expression in apoptosis induced Jurkat cells by anti-Fas monoclonal antibody using AM26608AF-N. AM26608AF-N react with pro-caspase-10 and Intermediate form. Mouse IgG1 4C1 Azide Free Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Caspase-10 Control Peptide

Caspase-10 Purified
50 µg / €190.00
  Acris Antibodies GmbH

Caspase-10 antibody

Western blot analysis of caspase-10 expression in Jurkat cells treated with camptothecin. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 mg / €370.00
  Acris Antibodies GmbH

Caspase-10 antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Caspase 10 antibody (Cat.-No. AP06036PU-N). Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Caspase-10 Control Peptide

Caspase-10
50 µg / €160.00
  Acris Antibodies GmbH

Caspase-10 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human Tonsil tissue stained with Caspase-10 Antibody Cat.-No AP32229PU-N at 5 µg/ml after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-10 antibody

CASP10 polyclonal antibody (A01), Lot # 051011JC01 Western Blot analysis of CASP10 expression in MES-SA/Dx5 ( Cat # L021V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Caspase-10 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CFLAR and CASP10. HeLa cells were stained with anti-CFLAR rabbit purified polyclonal 1:1200 and anti-CASP10 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG1 1D8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

Caspase-10 antibody

CASP10 monoclonal antibody (M02), clone 2E7. Western Blot analysis of CASP10 expression in U-2 OS ( Cat # L022V1 ). Mouse IgG2a 2E7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

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