Caspase-12 antibody

Principal name

Caspase-12 antibody

Alternative names for Caspase-12 antibody

CASP-12, CASP12, Inactive caspase-12

SwissProt ID

O08736 (Mouse), Q075B4 (Canfa), Q6UXS9 (Human), Q920D5 (Rat)

Gene ID

12364 (Casp12), 100506742 (CASP12), 100044205 (LOC100044205), 120329

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Rat, Goat

Available applications

Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Caspase-12 antibody

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3/caspase-1, is composed of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, caspase-10, caspase-14, and caspase- 5/caspase-12. Ced-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-5 (also designated TY or ICErelIII) can cleave its own precursor, an activity that requires the cysteine 245 residue. The mouse homolog of caspase-5 is designated caspase-12. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon and stomach, indicating that caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer.

General readings

General / background references:Nakagawa T et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103 (2000). PubMed PMID: 10638761
Nakagawa T & Yuan J Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 150:887-94 (2000). PubMed PMID: 10953012
Thornberry NA & Lazebnik Y Caspases: enemies within. Science 281:1312-6 (1998). PubMed PMID: 9721091
Cryns V & Yuan J Proteases to die for. Genes Dev 12:1551-70 (1998). PubMed PMID: 9620844
Kidd VJ Proteolytic activities that mediate apoptosis. Annu Rev Physiol 60:533-73 (1998). PubMed PMID: 9558476
Cohen GM Caspases: the executioners of apoptosis. Biochem J 326 ( Pt 1):1-16 (1997). PubMed PMID: 9337844

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-12 (N-term) antibody

Immunohistochemical detection of Caspase-12 on Paraffin-Embedded Section of ZR75-1 with AM20297AF-N Rat IgG2a 14F7 Azide Free Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Caspase-12 (100-116) antibody

Immunohistochemical staining of mouse liver tissue using Caspase-12 antibody at 2 µg/ml. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-12 (Center) antibody

CASP12 Antibody (Center) (Cat. #AP50732PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CASP12 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Caspase-12 (N-term) antibody

Western blot analysis of caspase-12 in human (A) and mouse (B) spleen tissue lysates with caspase-12 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-12 (Center) antibody

Western blot analysis of caspase-12 in mouse brain tissue lysate in the absence (A) or presence (B) of blocking peptide with caspase-12 antibody (IN) at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-12 antibody

Western blot analysis of caspase-12 in human heart lysate with caspase-12 antibody (large) at 0.5 (lane A), 1 (lane B), and 2 ug/ml (lane C), respectively. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-12 antibody

Western blot analysis of caspase-12 in mouse (lane A) and rat (lane B) liver lysate with caspase-12 antibody (small) at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-12 (232-244) antibody

(0.5ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-12 antibody

Predicted cell location: Cytoplasm. Positive control: Human brain and esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using CASP12 antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-12 antibody

Predicted band size: 55 kDa . Positive control: NIH/3T3 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 50 ug per lane Primary antibody: 1/700 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-12 antibody

Western Blot: Caspase 12 Antibody [TA337199] - Analysis at 1 ug/ml against 15 ug of mouse spleen cell lysate Rabbit Purified Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Caspase-12 (N-term) antibody

Immunocytochemical detection of Caspase-12 on 4% PFA fixed NIH/3T3 cells with AM20298AF-N Rat IgG2a 14F4 Azide Free Hu, Ms, Rt ICC/IF, IP, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Caspase-12 Control Peptide

Caspase-12 Purified
50 µg / €190.00
  Acris Antibodies GmbH

Caspase-12 antibody

Western blot analysis of Caspase-12 with rat kidney tissue lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Caspase-12 antibody

Staining of formailin fixed paraffin processed mouse liver with anti-Caspase 12 at 2 µg/ml (AP05835PU-N) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Caspase-12 antibody

Caspase-12 Rabbit IgG Purified Hu, Ms, Rt P, WB
50 µg / €280.00
  Acris Antibodies GmbH

Caspase-12 antibody

Figure 1. Staining CASP-12 in Brain, cortex by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-12 antibody

Immunohistochemistry (IHC) analyzes of Caspase12 antibody (Cat.-No.: AP20655PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Caspase-12 antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-12 Control Peptide

Caspase-12
50 µg / €160.00
  Acris Antibodies GmbH

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