Alternative names for Caspase-13 antibody
CASP13, ERICE, Evolutionary related interleukin-1-beta-converting enzyme
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)
Background of Caspase-13 antibody
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 b Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 is activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).
Humke, E.W., et al., (1998), ERICE, a novel FLICE-activatable caspase, J. Biol, Chem., 273, 15702-15707
Koenig U., Eckhart L., Tschachler E. (2001): Evidence that caspase-13 is not a human but a bovine gene Biochem. Biophys. Res. Commun. 285:1150-1154