Caspase-14 antibody

Principal name

Caspase-14 antibody

Alternative names for Caspase-14 antibody

CASP-14, CASP14

SwissProt ID

O89094 (Mouse), P31944 (Human)

Gene ID

23581 (CASP14), 12365 (Casp14)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

ChIP assay (ChIP), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Frozen Sections (C)

Background of Caspase-14 antibody

Caspases are a family of cysteine proteases that play key roles in apoptosis. The precursor form of all caspaes is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunits, which associate into a2b2 tetramers to form the active enzyme.
Caspase 14 also known as Mini ICE (MICE) is a member of the peptidase family C14 that has three potential isoforms. The pro form of Caspase 14 is approximately 29 kD. This caspase may be involved in the death receptor and granzyme B apoptotic pathways. Caspase 14 functions as downstream signal transducer of cell death that can be suppressed by retinoic acid. Caspase 14 becomes activated after granzyme B, Caspase 8, and Caspase 10 cleavage into large p18 and small p10 subunits. This caspase has been shown to associate with the large prodomain caspases, including Caspase 1, Caspase 2, Caspase 4, Caspase 8, and Caspase 10.
Its high expression in embryonic tissues and limited expression in adult tissues suggests that it may have a role in ontogenesis.

General readings

1. Pistritto, G., et al., Cell Death Differ. 9, 995-1006 (2002).
Clone 1-71 is used in this reference.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-14 antibody

Western blot analysis of caspase-14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with caspase-14 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-14 antibody

Sample (30 ug of whole cell lysate). A: A431 . 12% SDS PAGE. TA308792 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-14 antibody

Western blot analysis of extracts from COLO cells and HepG2 cells, using Caspase 14 (p10, Cleaved-Lys222) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-14 antibody

Western Blot: Caspase 14 Antibody (70A1426) [NB100-56718] - Western blot analysis for Caspase-14 using NB100-56718 at 2 ug/ml dilution against 10 ug of mouse spleen cell lysate. Mouse 70A1426 Purified Hu, Ms F, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

Caspase-14 antibody

Western blot analysis of caspase-14 expression in ZR75-1 (Lane 1) and MCF-7 (Lane 2) using AM20291AF-N Caspase 14 antibody. Mouse IgG1 1-71 Azide Free Hu ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Caspase-14 (C-term) antibody

Immunohistochemical staining of human liver with Rabbit anti caspase-14 (AP05590PU-N) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Caspase-14 (C-term) antibody

AP07689PU-N Caspase-14 antibody staining of Formalin-Fixed Paraffin-Embedded Human Skin at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-14 Control Peptide

Caspase-14
50 µg / €160.00
  Acris Antibodies GmbH

Caspase-14 antibody

Skin stained in IHC-P with Caspase-14 antibody Rabbit Purified Hu E, P, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Caspase-14 antibody

Caspase-14 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Caspase-14 antibody

Immunofluorescence of monoclonal antibody to CASP14 on HeLa cell. [antibody concentration 15 ug/ml] Mouse IgG2a 4C9 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Caspase-14 antibody

Formalin-fixed paraffin-embedded tissue sections of human cervix stained for CASP14 expression. Using CASP14 polyclonal antibody ( Cat # PAB0250 ) at 1 : 2000. A. Normal cervix ( squamous epithelium ) . B. CIN1 ( low-grade squamous intraepithelial lesion, mild dysplasia ) . C. CIN2 ( high-grade squamous intraepithelial lesion, moderate dysplasia ) . D. CIN3 ( high-grade squamous intraepithelial lesion ; severe dysplasia-carcinoma in situ ) . In normal cervi, CASP14 staining was found most in the midzone layer, but was absent from the basal/parabasal cell layer where mitotically active cells are known to reside. This suggests induction of CASP14 expression with differentiation. CASP14 expression declined progressively during malignant transformation as the histologic severity of the cervical atypia advanced from CIN1 to CIN3. Hematoxylin-eosin counterstain. Rabbit Hu, Ms, Rt IP, P, WB
50 µl / €400.00
  Abnova Taiwan Corp.

Caspase-14 antibody

Immunohistochemistry of CASP14 in human liver tissue with CASP14 polyclonal antibody ( Cat # PAB12873 ) at 2.5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Caspase-14 antibody

Caspase-14 Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €290.00
  Boster Immunoleader

Caspase-14 antibody

Western blot analysis of Caspase 14 p10 expression in MCF7 (A); mouse spleen (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Caspase-14 antibody

Western blot analysis of Caspase 14 p10 expression in MCF7 (A); mouse spleen (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Caspase-14 antibody

Western blot analysis of Caspase 14 p10 expression in MCF7 (A); mouse spleen (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Caspase-14 antibody

Caspase-14 Rabbit Serum Hu ChIP, P, WB
0.1 ml / €320.00
  Novus Biologicals Inc.

Caspase-14 antibody

Caspase-14 Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Caspase-14

Caspase-14 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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