Caspase-4 antibody

Principal name

Caspase-4 antibody

Alternative names for Caspase-4 antibody

CASP4, ICH2, ICE(rel)-II, Protease ICH-2, Protease TX

SwissProt ID

P49662 (Human), P70343 (Mouse), Q3MHS1 (Rat), Q5E9C1 (Bovin)

Gene ID

12363 (Casp4), 837 (CASP4), 338039

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Mky (Monkey), Bov (Bovine), Can (Canine)

Available hosts

Rat, Rabbit, Chicken, Mouse, Goat

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E)

Background of Caspase-4 antibody

A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, termed Ced-3/caspase-1, is comprised of caspase- 1, caspase-2, caspase-3, caspase-4, caspase-6 and caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9, and caspase-10. Ced- 3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the 112 kDa nuclear protein PARP into an 85 kDa apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.

General readings

General / background references:Thornberry NA & Lazebnik Y Caspases: enemies within. Science 281:1312-6 (1998). PubMed PMID: 9721091
Cohen GM Caspases: the executioners of apoptosis. Biochem J 326 ( Pt 1):1-16 (1997). PubMed PMID: 9337844
Kamens J et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. J Biol Chem 270:15250-6 (1995). PubMed PMID: 7797510

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-4 antibody

TA302442 (0.3µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-4 (N-term) antibody

Western blot analysis of caspase-4 in Ramos cells with caspase-4 antibody at (A) 0.5 and (B) 1 ugg/ml. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-4 (Center) antibody

Western blot analysis of caspase-4 in human spleen cells with caspase-4 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-4 antibody

Western blot analysis of extracts from Jurkat cells, using CASP4 (p20, Cleaved-Gln81) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-4 antibody

Western blot analysis of extracts from Jurkat cells, using Caspase 4/5 (p20, Cleaved-Asp270/Asp311) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-4 antibody

Western blot analysis of Raw264.7 cells starved overnight(lane 1), Raw264.7 cells starved overnight and treated with 1 ug/ml LPS for nine hours (lane 2) and NIH3T3 untreated cells (lane 3) using anti-Caspase11 antibody (clone cas11.17D9). Rat IgG2a Cas11.17D9 Purified Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-4 antibody

Western blot analysis of caspase-13 in human HL60 cell lysate (A), mouse brain (B) and rat brain (C) tissue lysates with caspase-13 antibody at 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CASP4 (RC204711, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CASP4.(1:2000) Mouse IgG1 OTI4A2 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Caspase-4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CASP4 (RC204711, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CASP4. Mouse IgG1 OTI9F6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Caspase-4 antibody

Western blot analysis of caspase-4 in 293 cell lysate. Mouse IgG1 D44 Purified Hu WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Caspase-4 (1-270) antibody

Western blot analysis of Caspase-4 fragments expression in apoptosis induced SK-N-SH cells by 1 μg/mL tunicamycin using AM26585AF-N. AM26585AF-N reacts with pro-caspase-4 and cleaved form. Mouse IgG1 4B9 Azide Free Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Caspase-4 antibody

Western blot analysis of Raw264.7 cells starved overnight(lane 1), Raw264.7 cells starved overnight and treated with 1 ug/ml LPS for nine hours (lane 2) and NIH3T3 untreated cells (lane 3) using anti-Caspase11 antibody (clone cas11.17D9). Rat IgG2a Cas11.17D9 Purified Ms WB
25 µg / €230.00
  Acris Antibodies GmbH

Caspase-4 Control Peptide

Caspase-4 Purified
50 µg / €190.00
  Acris Antibodies GmbH

Caspase-4 antibody

Western blot analysis of caspase-4 expression in HeLa cell extract. Rabbit Aff - Purified Hu, Mky WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Caspase-4 antibody

Figure 1. Staining Caspase-4 (CASP4) in Heart by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-4 (1-89) antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Chicken Ig Azide Free Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-4 antibody

Immunohistochemistry (IHC) analyzes of Caspase-4 antibody (Cat.-No.: AP20779PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Caspase-4 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human Pancreas stained with Caspase-4 antibody Ca.-No AP22937PU-N at 5 µg/ml after heat-induced antigen retrieval. Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-4 antibody

Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-4 Control Peptide

Caspase-4
50 µg / €160.00
  Acris Antibodies GmbH

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