Caspase-5 antibody

Principal name

Caspase-5 antibody

Alternative names for Caspase-5 antibody

CASP-5, CASP5, ICH3, ICH-3 protease, TY protease, ICE(rel)-III

SwissProt ID

P51878 (Human)

Gene ID

838 (CASP5)

Available reactivities

Bov (Bovine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Rb (Rabbit), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of Caspase-5 antibody

Apoptosis is a major form of cell death characterized by morphological features including chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathways that lead to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitm ent to cell death. Caspase-5 (also known as ICE rel -III or ICH-3) is a ~47 kDa member of the ICE/CED-3 family of cysteine proteases. This protein has 51% sequence identity with human interleukin-1- β - converting enzyme, 27% sequence identity with ICH-1 L, 30% identity with human CPP32, and 24% sequence identity with the C. elegans CED-3 polypeptide. This ICE subfamily of caspase includes caspase-1, caspase-5, caspase-4, and caspase-13, and appears to play a primary role in cytokine maturation and inflammation.

General readings

1. Wang, S. et al. (1996) Identification and characterization of Ich-3, a member of the Interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271: 20580-20587.
2. Lin, X.Y. et al. (2000) Expression analysis of the human Caspase-1 subfamily reveals specific regulation of the
CASP5 gene by Lipopolysaccharide and Interferon-gamma. J. Biol. Chem. 275: 39920-39926.
3. Munday, N.A. et al. (1995) Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270: 15870-15876.
4. Cohen, G.M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326: 1-16.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-5 (N-term) antibody

Western blot analysis of Caspase-5 in Ramos cells with Caspase-5 antibody at (A) 0.5, (B) 1, and (C) 2 µg/ml. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-5 (Center) antibody

Western blot analysis of caspase-5 in Ramos cells with caspase-5 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-5 antibody

Western blot analysis of extracts from HeLa cells and A549 cells, treated with etoposide (25uM, 24hours), using CASP5 (p20, Cleaved-Asp121) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-5 antibody

Western blot analysis of extracts from 293 cells, treated with etoposide (25uM, 1hour), using CASP5 (p10, Cleaved-Ser331) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-5 (202-419) antibody

Western blot analysis of Caspase-5 expression in HL-60 (1), HeLa (2), NIH/3T3 (3) and PC12 (4) using AM26609AF-N. Mouse IgG1 4F7 Azide Free Hu, Ms, Rt WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Caspase-5 Control Peptide

Caspase-5 Purified
50 µg / €190.00
  Acris Antibodies GmbH

Caspase-5 antibody

Caspase-5 Rabbit Aff - Purified Bov, Hst, Hu, Mky, Ms, Rb, Rt WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Caspase-5 antibody

Immunocytochemical staining of P815 mouse mastocytoma cells with Rabbit anti Human caspase-5 (AP05927PU-N) Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Caspase-5 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cerebellum. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-5 Control Peptide

Caspase-5
50 µg / €160.00
  Acris Antibodies GmbH

Caspase-5 Control Peptide

Caspase-5
50 µg / €160.00
  Acris Antibodies GmbH

Caspase-5 (Center) antibody

CASP5 Antibody (Center) (Cat. #AP50734PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CASP5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Caspase-5 antibody

CASP5 polyclonal antibody (A01), Lot # 060608JCS1 Western Blot analysis of CASP5 expression in U-2 OS ( Cat # L022V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Caspase-5 antibody

Caspase-5 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

Caspase-5 antibody

Western blot analysis of CASP5 expression in rat kidney tissue lysate. Rabbit Bov, Hst, Hu, Mky, Ms, Rb, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Caspase-5 antibody

Western blot analysis of CASP5 in Ramos cells with CASP5 polyclonal antibody ( Cat # PAB9826 ) at ( A ) 0.5, ( B ) 1, and ( C ) 2 µg/ml. Rabbit Hu C, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Caspase-5 antibody

Western blot analysis of CASP5 in Ramos cells with CASP5 polyclonal antibody at ( A ) 0.5, ( B ) 1, and ( C ) 2 µg/ml. Rabbit Hu WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Caspase-5 (cleaved) antibody

Western blot analysis of extracts from HeLa/A549 cells, treated with etoposide 25uM 24h, using Caspase 5 (p20,Cleaved-Asp121) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

Caspase-5 (cleaved) antibody

Western blot analysis of extracts from HeLa/A549 cells, treated with etoposide 25uM 24h, using Caspase 5 (p20,Cleaved-Asp121) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

Caspase-5 (cleaved) antibody

Western blot analysis of extracts from 293 cells, treated with etoposide 25uM 1h, using Caspase 5 (p10,Cleaved-Ser331) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

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