Caspase-5 antibody
Principal name
Caspase-5 antibody
Alternative names for Caspase-5 antibody
CASP-5, CASP5, ICH3, ICH-3 protease, TY protease, ICE(rel)-III
SwissProt ID
P51878 (Human)
Gene ID
838 (CASP5)
Ncbi ID
NP_001129581.1, NP_001129581, ADR83176.1, NM_004347, NM_001136109, NP_004338, P51878, NM_001136112
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)
Background of Caspase-5 antibody
Apoptosis is a major form of cell death characterized by morphological features including chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathways that lead to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitm ent to cell death. Caspase-5 (also known as ICE rel -III or ICH-3) is a ~47 kDa member of the ICE/CED-3 family of cysteine proteases. This protein has 51% sequence identity with human interleukin-1- β - converting enzyme, 27% sequence identity with ICH-1 L, 30% identity with human CPP32, and 24% sequence identity with the C. elegans CED-3 polypeptide. This ICE subfamily of caspase includes caspase-1, caspase-5, caspase-4, and caspase-13, and appears to play a primary role in cytokine maturation and inflammation.
General readings
1. Wang, S. et al. (1996) Identification and characterization of Ich-3, a member of the Interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271: 20580-20587.
2. Lin, X.Y. et al. (2000) Expression analysis of the human Caspase-1 subfamily reveals specific regulation of the
CASP5 gene by Lipopolysaccharide and Interferon-gamma. J. Biol. Chem. 275: 39920-39926.
3. Munday, N.A. et al. (1995) Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270: 15870-15876.
4. Cohen, G.M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326: 1-16.










Western blot analysis of Caspase-5 expression in HL-60 (1), HeLa (2), NIH/3T3 (3) and PC12 (4) using AM26609AF-N.





Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA306197 | Caspase-5 (N-term) antibody |
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Rabbit Polyclonal Caspase-5 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu | E, WB |
0.1 mg /
€371.00
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OriGene Technologies, Inc. | |||||||
TA306198 | Caspase-5 (Center) antibody |
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Rabbit Polyclonal Caspase-5 Antibody | |||||||
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Rabbit | IgG | Aff - Purified | Hu | E, ICC/IF, WB |
0.1 mg /
€371.00
|
|
OriGene Technologies, Inc. | |||||||
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TA312148 | Caspase-5 antibody |
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Rabbit polyclonal CASP5 (p20, Cleaved-Asp121) antibody | |||||||
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Rabbit | IgG | Purified | Hu | WB |
0.1 ml /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
TA312149 | Caspase-5 antibody |
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Rabbit polyclonal CASP5 (p10, Cleaved-Ser331) antibody | |||||||
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Rabbit | IgG | Purified | Hu | WB |
0.1 ml /
€335.00
|
|
OriGene Technologies, Inc. | |||||||
AM26609AF-N | Caspase-5 (202-419) antibody |
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Mouse | IgG1 | 4F7 | Azide Free | Hu, Ms, Rt | WB |
0.1 mg /
€360.00
|
Acris Antibodies GmbH | |||||||
AP00012CP-N | Caspase-5 Control Peptide |
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Purified |
50 µg /
€180.00
|
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Acris Antibodies GmbH | |||||||
AP00012PU-N | Caspase-5 antibody |
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Rabbit | Aff - Purified | Bov, Hst, Hu, Mky, Ms, Rb, Rt | WB |
0.1 mg /
€330.00
|
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Acris Antibodies GmbH | |||||||
AP05927PU-N | Caspase-5 antibody |
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Rabbit | IgG | Purified | Hu | ICC/IF, WB |
0.1 mg /
€330.00
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Acris Antibodies GmbH | |||||||
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AP07691PU-N | Caspase-5 antibody |
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Rabbit | Aff - Purified | Hu | ICC/IF, P, WB |
50 µg /
€380.00
|
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Acris Antibodies GmbH | |||||||
AP50734PU-N | Caspase-5 (Center) antibody |
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Rabbit | Ig | Aff - Purified | Hu | F, P, WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
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L0158-1 | Caspase-5 (cleaved) antibody |
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Rabbit | Aff - Purified | Hu | E, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
L0158-2 | Caspase-5 (cleaved) antibody |
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Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
€330.00
|
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Assay Biotech | |||||||
L0159-1 | Caspase-5 (cleaved) antibody |
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Rabbit | Aff - Purified | Hu | E, WB |
50 µg /
€230.00
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Assay Biotech | |||||||
L0159-2 | Caspase-5 (cleaved) antibody |
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Rabbit | Aff - Purified | Hu | E, WB |
0.1 mg /
€330.00
|
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Assay Biotech |
Proteins & Growth Factors
Catalog No. | Species | Pres. | Purity | Source | |
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TP760220 | Caspase-5 (full length, N-term HIS tag, transcript variant a) |
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Recombinant protein of human caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant a, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug | |||||
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Human | > 80 % Preparation: . Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
E. coli |
50 µg /
€199.00
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|
OriGene Technologies, Inc. |
Lysates
Catalog No. | ||
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LY401386 | CASP5 overexpression lysate |
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0.1 mg /
€295.00
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|
OriGene Technologies, Inc. | ||
LY427803 | CASP5 overexpression lysate |
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0.1 mg /
€295.00
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OriGene Technologies, Inc. |
Human Lenti ORF Particles
Catalog No. | ||
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RC210421L2V | Lenti ORF particles, CASP5 (mGFP-tagged) - Human caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant a, 200 uL, >10^7 TU/mL |
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200 µl /
€1,061.00
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OriGene Technologies, Inc. | ||
RC226582L2V | Lenti ORF particles, CASP5 (mGFP-tagged) - Human caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant f, 200 uL, >10^7 TU/mL |
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200 µl /
€1,082.00
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OriGene Technologies, Inc. | ||
RC210421L1V | Lenti ORF particles, CASP5 (Myc-DDK tagged) - Human caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant a , 200 uL, >10^7 TU/mL |
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200 µl /
€948.00
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OriGene Technologies, Inc. | ||