Caspase-5 antibody

Principal name

Caspase-5 antibody

Alternative names for Caspase-5 antibody

CASP-5, CASP5, ICH3, ICH-3 protease, TY protease, ICE(rel)-III

SwissProt ID

P51878 (Human)

Gene ID

838 (CASP5)

Available reactivities

Bov (Bovine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Rb (Rabbit), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F)

Background of Caspase-5 antibody

Apoptosis is a major form of cell death characterized by morphological features including chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur via signaling pathways that lead to the recruitment and activation of caspases, a family of cysteine-containing, aspartate-specific proteases. Caspases exist as inactive proenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitm ent to cell death. Caspase-5 (also known as ICE rel -III or ICH-3) is a ~47 kDa member of the ICE/CED-3 family of cysteine proteases. This protein has 51% sequence identity with human interleukin-1- β - converting enzyme, 27% sequence identity with ICH-1 L, 30% identity with human CPP32, and 24% sequence identity with the C. elegans CED-3 polypeptide. This ICE subfamily of caspase includes caspase-1, caspase-5, caspase-4, and caspase-13, and appears to play a primary role in cytokine maturation and inflammation.

General readings

1. Wang, S. et al. (1996) Identification and characterization of Ich-3, a member of the Interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271: 20580-20587.
2. Lin, X.Y. et al. (2000) Expression analysis of the human Caspase-1 subfamily reveals specific regulation of the
CASP5 gene by Lipopolysaccharide and Interferon-gamma. J. Biol. Chem. 275: 39920-39926.
3. Munday, N.A. et al. (1995) Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases. J. Biol. Chem. 270: 15870-15876.
4. Cohen, G.M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326: 1-16.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-5 (Center) antibody

CASP5 Antibody (Center) (Cat. #AP50734PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CASP5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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