Caspase-6 antibody

Principal name

Caspase-6 antibody

Alternative names for Caspase-6 antibody

CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2

SwissProt ID

O08738 (Mouse), O35397 (Rat), P55212 (Human), Q3T0P5 (Bovin)

Gene ID

839 (CASP6), 12368 (Casp6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Caspase-6 antibody

Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a member of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to form caspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, the N-terminal is removed and the proenzyme is converted into a large (p18) and small (p11) subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression of the isoform of caspase-6 without its prodomain can induce apoptosis. The isoform does not seem to display proteolytic activity. Together with caspases-3 and -7, the isoform of caspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 and caspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins such as lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 in cytochrome-C dependent apoptosis was reported recently.

General readings

Nakamura,T., (2004) J. Biol. Chem. 279 (1), 626-634

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-6 (Center) antibody

  Rabbit Polyclonal Caspase-6 Antibody  
Western blot analysis of Caspase-6 in MCF7 cell lysate with Caspase-6 antibody (IN) at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

Caspase-6 (N-term) antibody

  Rabbit Polyclonal Caspase-6 Antibody  
Western blot analysis of caspase-6 in Jurkat cell lysate with caspase-6 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

Caspase-6 (alpha) antibody

  Goat Polyclonal Caspase 6 (alpha) Antibody  
Anti-CASP6 (0.5ug/ml) staining of Human Colon lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

Caspase-6 antibody

  Goat Polyclonal Caspase 6 Antibody  
Anti-CASP6 (0.3ug/ml) staining of Human Colon lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

Caspase-6 (C-term) antibody

  Rabbit polyclonal CASP6 Antibody (C-term)  
Western blot analysis of anti-CASP6 Antibody (C-term) (Cat.#TA324510) in mouse liver tissue lysates (35ug/lane). CASP6 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €410.00
  OriGene Technologies, Inc.

Caspase-6 (active) antibody

Caspase-6 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Caspase-6 antibody

Western blot analysis of Caspase-6 expression rat kidney tissue lysate. Both full length and the cleaved large fragment have been detected. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €330.00
  Acris Antibodies GmbH

Caspase-6 antibody

Skeletal muscle: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €380.00
  Acris Antibodies GmbH

Caspase-6 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Prostate. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €380.00
  Acris Antibodies GmbH

Caspase-6 pSer257 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Caspase-6 pSer257 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using Caspase 6 (Phospho-Ser257) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Caspase-6 pSer257 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using Caspase 6 (Phospho-Ser257) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

Caspase-6 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Caspase 6 (Ab-257) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

Caspase-6 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Caspase 6 (Ab-257) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

Caspase-6 (cleaved) antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

Caspase-6 (cleaved) antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

Caspase-6 (cleaved) antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

Caspase-6 (cleaved) antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Caspase 6 (Cleaved-Asp162) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

18 Item(s)

per page
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