Caspase-6 antibody

Principal name

Caspase-6 antibody

Alternative names for Caspase-6 antibody

CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2

SwissProt ID

O08738 (Mouse), O35397 (Rat), P55212 (Human), Q3T0P5 (Bovin)

Gene ID

839 (CASP6), 12368 (Casp6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), ELISA (detection) (E(detection))

Background of Caspase-6 antibody

Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a member of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to form caspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, the N-terminal is removed and the proenzyme is converted into a large (p18) and small (p11) subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression of the isoform of caspase-6 without its prodomain can induce apoptosis. The isoform does not seem to display proteolytic activity. Together with caspases-3 and -7, the isoform of caspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 and caspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins such as lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 in cytochrome-C dependent apoptosis was reported recently.

General readings

Nakamura,T., (2004) J. Biol. Chem. 279 (1), 626-634

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Lysates (Knockout)

Catalog No.    

CASP6-knockout Cell lysate

CASP6-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

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