Caspase-7 antibody

Principal name

Caspase-7 antibody

Alternative names for Caspase-7 antibody

CASP-7, CASP7, MCH3, CMH-1, ICE-like apoptotic protease 3, Apoptotic protease Mch-3

SwissProt ID

P55210 (Human), P97864 (Mouse)

Gene ID

840 (CASP7)

Available reactivities

Hu (Human), Can (Canine), Hst (Hamster), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep)

Available hosts

Rabbit, Mouse, Rat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Caspase-7 antibody

Apoptosis is a major form of cell death characterized by morpho logical features including chromatin condensation and fragmentation, cell membrane blebbing, and formation of apoptotic bodies. These morphological changes occur vi a signaling pathways that lead to the recruitment and activation of caspases, a family of cysteine-containing, as partate-specific proteases. Caspases exist as inactive pr oenzymes in cells and are activated through their processing into two subunits in response to apoptotic stimulation. Activated caspases cleave a variety of important cellular proteins, other caspases, and Bcl-2 family members, leading to a commitment to cell death. Casp ase-7 (also known as Mch-3 / ICE-LAP3 / CMH-1) is a 35 kDa protein that has the highest similarity to caspase-3 (52% amino acid identity) among all caspase members. It has been identified as one of the ''effector'' caspases (which include caspase 3, 6, 7) that are cleaved by ''initiator'' caspases (which include caspase 8, 9) into active form, and then, in turn, cleave various cellular proteins for apoptosis. Recent study says that in Fas-mediated hepatocyte apoptosis, active caspase-7 is associated almost exclusivel y with the mitochondrial and microsomal fractions, whereas active caspase-3 is confined primarily to the cytosol. It implies a different role of caspase-3 and -7 in the execution of apoptosis.

General readings

1. Cohen, G.M., et al. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326, 1-16.
2. Chandler, J.M., et al. Different subcellular distribution of Caspase-3 and Caspase-7 following
Fas-induced apoptosis in mouse liver. J. Bio. Chem. 1998, 273, 10815-10818.
3. Behrensdorf, H.A., et al. The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7. FEBS Lett. 2000, 466, 143-147.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-7 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-CASP7 rabbit polyclonal antibody. (TA590426) Rabbit IgG Purified Hu, Mky, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western Blot: Caspase 7 Antibody (Mch3 1-1-11) TA301617 - HeLa whole cell lysate. Mouse IgG1 Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 (C-term) antibody

Western blot analysis of Caspase-7 in human skeletal muscle cell lysate with Caspase-7 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-7 (N-term) antibody

Western blot analysis of Caspase-7 in mouse skeletal muscle cell lysate with Caspase-7 antibody at (A) 0.5 and (B) 1 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western blot analysis of extracts from Jurkat cells, treated with Etoposide (25µM, 24hours), using Caspase 7 (Cleaved-Asp198) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western blot analysis of extracts from 293 cells, treated with Etoposide (25uM, 60mins), using Caspase 7 (cleaved-Asp198) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 24hours), using CASP7 (p20, Cleaved-Asp198) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western blot analysis of extracts from 293 cells and A549 cells, using Caspase 7 (p11, Cleaved-Ala207) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Predicted band size: 34 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8+12%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/186 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Predicted cell location: Cytoplasm. Positive control: Human thyroid and lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using CASP7 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western blot analysis of extracts of various cell lines, using Caspase7 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Western Blot: Caspase 7 Antibody (25B881.1) [TA336390] - analysis of Caspase-7 in A) human brain, B) mouse brain and C) rat brain lysate using Caspase-7 antibody at 1 ug/ml. Mouse IgG1 25B881.1 Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-7 antibody

Caspase-7 Mouse IgG1 B4-G2 Purified Hu, Ms, Rt IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Caspase-7 antibody

Caspase-7 Mouse IgG1 MCH3 14 1-11 Purified Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Caspase-7 antibody

Figure 1. Western blot analysis using caspase-7 antibody (AM05296PU-N) on MCF-7 cells treated with thapsigargin for 48 hours which are negative (-) and positive (+) for caspase-3. Mouse IgG MCH3-5 Purified Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

Caspase-7 (Active Form) antibody

Formalin-Fixed, Paraffin-Embedded Human Small intestine stained with Caspase-7 Antibody Cat.-No AM08364PU-N at 10 µg/ml after heat-induced antigen retrieval. Mouse IgG1 25B881.1 Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-7 antibody

AM20344PU-N Caspase-7 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Mouse IgG 7-1-11 Purified Can, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-7 antibody

AM20348PU-N Caspase-7 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Mouse IgG 10-1-62 Purified Hst, Hu, Mky, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-7 antibody

Western blot analysis of untreated Jurkat cells(lane 1) and Jurkat cells treated with 1 µM Etoposide for five hours(lane 2) and anti-Capsase-7 Antibody Cat.-No AM20420PU-S (Clone 20F3). GAPDH antibody was used as loading control. Rat IgG2a 20F3 Purified Hu, Ms WB
25 µg / €240.00
  Acris Antibodies GmbH

Caspase-7 (1-198) antibody

Western blot analysis of Caspase-7 fragments expression in apoptosis induced Jurkat cells by anti-Fas monoclonal antibody using AM26602AF-N. AM26602AF-N react with pro-caspase-7, Intermediate form and active form. Mouse IgG2b 4G2 Azide Free Hu, Ms, Rt IP, WB
0.1 mg / €360.00
  Acris Antibodies GmbH

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