Caspase-8 / FLICE antibody

Principal name

Caspase-8 / FLICE antibody

Alternative names for Caspase-8 / FLICE antibody

CASP-8, CASP8, MCH5, CAP4, ICE-like apoptotic protease 5, MORT1-associated CED-3 homolog, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, Apoptotic cysteine protease, Apoptotic protease Mch-5

SwissProt ID

O89110 (Mouse), Q14790 (Human), Q9JHX4

Gene ID

841 (CASP8), 12370 (Casp8), 64044

Available reactivities

Hu (Human), Bov (Bovine), Mky (Monkey), Ms (Mouse), Rt (Rat), Ge (Gerbil), Prim (Primate)

Available hosts

Mouse, Rabbit, Rat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Flow Cytometry (F)

Background of Caspase-8 / FLICE antibody

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death.
Caspase-8 is involved in the apoptosis mediated by CD95 and TNFR-1. It is suggested that following the triggering of apoptosis by CD95 or TNFR-1, the adaptor molecule FADD interact physically with cytosolic caspase-8 and initiate the apoptotic cascade. The active caspase-8 consists of two subunits of p18 and p10. 
Structure: Full length protein of 55kd. Contains two homologous domains of DED (death effector domain) of FADD. The remainder of the protein is similar to the CED-3 subfamily of caspases.
Distribution: Expressed in multiple isoforms in multiple tissues. Relatively high level in peripheral leucocytes.
Function: Caspase-8 is involved in apoptosis mediated by CD95 and TNFR-1.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Caspase-8 / FLICE (C-term) antibody

  Rabbit polyclonal CASP8 Antibody (C-term)  
Western blot analysis of CASP8 antibody (C-term) (Cat. #TA324849) in Hela cell line lysates (35ug/lane). CASP8 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

Immunohistochemical analysis of paraffin-embedded liver cancer tissues using CASP8 mouse mAb with DAB staining. Mouse IgG1 1H11 Ascites Hu, Mky, Ms, Rt E, F, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Caspase-8 / FLICE (C-term) antibody

Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Caspase-8 / FLICE (C-term) antibody

  Rabbit Polyclonal Caspase-8 Antibody  
Western blot analysis of caspase-8 in Jurkat cell lysate with caspase-8 antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal Caspase-8 Antibody  
Western blot analysis of Caspase-8 in HT-29 cell lysate with Caspase-8 antibody (IN) at 1 µg/ml in (A) the presence or (B) the absence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal antibody to Caspase 8 (caspase 8, apoptosis-related cysteine peptidase)  
Sample(30 ug whole cell lysate). A:HeLa S3. 7.5% SDS PAGE. TA308860 diluted at 1:500 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit polyclonal CASP8 (Cleaved-Asp384) antibody  
Western blot analysis of extracts from 293 cells, treated with etoposide (25uM, 1hour), using CASP8 (Cleaved-Asp384) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit polyclonal Caspase 8 (Tyr380) antibody(Phospho-specific)  
Western blot analysis of extracts from LOVO cells, treated with UV (15mins), using Caspase 8 (Phospho-Tyr380) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Anti-CASP8 Rabbit Polyclonal Antibody  
Predicted band size: 55 kDa . Positive control: 293, Hela and HT29 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 10%SDS-PAGE Lane1,2,3: 293, Hela and HT29 cells lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal Caspase 8 Antibody  
Western blot analysis of Caspase 8 expression in TNF-a treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal Caspase 8 (Ser347) Antibody (Phospho-specific)  
Western blot analysis of Caspase 8 phosphorylation expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  CASP8 Rabbit Polyclonal Antibody  
Western blot analysis of HeLa cells treated with cycloheximide (CHX) and TNF-alpha using CASP8 antibody. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal active/cleaved Caspase 8 Antibody  
Immunohistochemistry: Caspase 8 Antibody [TA336325] - Formalin-fixed, paraffin-embedded sections from a brain tissue array stained for Caspase-8 expression using TA336325 at 1:2000. A. Normal brain stem (1) and cortex (2). B. Higher magnification of corte Rabbit Purified Ge, Hu, Ms, Rt C, ICC/IF, IP, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Mouse Monoclonal Caspase-8 Antibody (90A992)  
Western Blot: Caspase 8 Antibody (90A992) [TA336388] - Western blot analysis of Caspase-8 in Jurkat cells using Caspase-8 antibody at 1 ug/ml. Cells were treated with 2 uM staurosporine for different time periods. Caspase-8 activation is detected in weste Mouse IgG1 90A992 Purified Hu, Prim F, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Mouse Monoclonal Caspase-8 Antibody (FLICE 4-1-20)  
Western Blot: Caspase 8 Antibody (FLICE 4-1-20) [TA336653] - Detection of Caspase 8 (59 kDa) from HEK293 cell extract using TA336653 (1:500). Lanes 1 and 2 contain inactive and active Caspase 8, respectively. Mouse IgG1 FLICE 4-1-20 Purified Hu WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal anti-Caspase-8 Antibody  
Human Stomach stained with anti-Caspase-8 antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE antibody

  Rabbit Polyclonal Caspase 8 Antibody  
ELISA: Caspase 8 Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Caspase-8 / FLICE (10 kDa subunit) antibody

Caspase-8 / FLICE Mouse IgG1 C502S Aff - Purified Hu IP, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Caspase-8 / FLICE antibody

Figure 1. Western blot analysis using caspase-8 antibody (AM05285PU-N) on MCF-7 cells negative (-) and positive (+) for caspase-3 after treatment for 48 hours with thapsigargin. Antibody detects procaspase and one cleavage product Mouse IgG FLICE 1 1-37 Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

Caspase-8 / FLICE antibody

Figure 1. Western blot analysis using caspase-8 antibody (AM05286PU-N) on MCF-7 cells negative (-) and positive (+) for caspase-3 after treatment for 48 hours with thapsigargin. Antibody detects procaspase and one cleavage product. Mouse IgG FLICE 3 Purified Hu WB
0.1 mg / €370.00
  Acris Antibodies GmbH

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