Cathepsin B antibody

Principal name

Cathepsin B antibody

Alternative names for Cathepsin B antibody

Cathepsin B1, APP secretase, APPS, CTSB, CPSB

SwissProt ID

A1E295 (Pig), P00787 (Rat), P07688 (Bovin), P07858 (Human), P10605 (Mouse)

Gene ID

1508 (CTSB), 13030 (Ctsb)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Goat, Mouse, Sheep, Rat

Available applications

Flow Cytometry (F), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunodiffusion (ID), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of Cathepsin B antibody

Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene.1, 2 And this gene is mapped to chromosome 8p22.3 The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of β-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade β-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease.4 Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. The standard product used in this kit is recombinant human Cathepsin B with the molecular mass of 37KDa.

General readings

This product has been used in:Ravikumar B et al. Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy. Hum Mol Genet 12:985-94 (2003). PubMed PMID: 12700167
General / background references:Strojnik T et al. Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin Cancer Res 5:559-67 (1999). PubMed PMID: 10100707

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cathepsin B antibody

Cells were scratch-wounded and stained against cathepsin B and annexin-II heterotetramer subunit p11 after 1 (a), 8 (b) and 24 (c) hours. Fixation was performed with both -20oC cold methanol and acetone for 8 minutes each. Cathepsin B is shown in red, p11 is shown in green. Goat Aff - Purified Ms C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

Cathepsin B antibody

Western Blot: Cathepsin B Antibody [TA336744] - extracts from COLO cells. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin B antibody

Predicted cell location: Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/150-500  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CTSB antibody at dilution 1/140, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin B antibody

Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/50-100  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CTSB antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin B Control Peptide

Cathepsin B Purified
50 µg / €190.00
  Acris Antibodies GmbH

Cathepsin B antibody

Western blot analysis of Cathepsin B with Jurkat cell (Lane 1) and mouse small intestine tissue (Lane 2) lysate. Rabbit Purified Hu, Ms, Rt F, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Cathepsin B antibody

Immunohistochemistry analysis of Cathepsin B Antibody (Cat.-No.: AP20651PU-N) in Paraffin-Embedded Human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cathepsin B antibody

Cathepsin B Mouse IgG2b CB131 Supernatant Hu P
1 ml / €530.00
  Acris Antibodies GmbH

Cathepsin B antibody

Cathepsin B Sheep Purified Hu ID, WB
1 ml / €430.00
  Acris Antibodies GmbH

Cathepsin B antibody

CTSB MaxPab polyclonal antibody. Western Blot analysis of CTSB expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cathepsin B antibody

Cathepsin B Mouse IgG2b CB131 Hu P
1 ml / €820.00
  Abnova Taiwan Corp.

Cathepsin B antibody

Western blot analysis of CTSB expression in Jurkat cell ( Lane 1 ) and mouse small intestine tissue ( Lane 2 ) lysate. Rabbit Hu, Ms, Rt C, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

Cathepsin B antibody

Western blot analysis of Cathepsin B expression in SW480 (A) whole cell lysates. Rabbit Aff - Purified Hu, Mky WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Cathepsin B antibody

Western blot analysis of Cathepsin B expression in SW480 (A) whole cell lysates. Rabbit Aff - Purified Hu, Mky WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Cathepsin B antibody

Western blot analysis of Cathepsin B expression in SW480 (A) whole cell lysates. Rabbit Aff - Purified Hu, Mky WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Cathepsin B antibody

Cathepsin B Goat Aff - Purified Hu WB
0.1 mg / €450.00
  Neuromics Antibodies

Cathepsin B antibody

Cathepsin B Mouse IgG2b CB131 Hu P
0.5 ml / €440.00
  Novus Biologicals Inc.

Cathepsin B antibody

ELISA: CATHEPSIN B Antibody [NBP1-21424] Sheep IgG HRP Hu E
0.5 ml / €800.00
  Novus Biologicals Inc.

Cathepsin B antibody

Cathepsin B Sheep FITC Hu E
0.5 ml / €780.00
  Novus Biologicals Inc.

Cathepsin B antibody

Western Blot: Cathepsin B Antibody [NBP1-45456] - Western blot analysis of Cathepsin B with Jurkat cell (Lane 1) and mouse small intestine tissue (Lane 2) lysate. Rabbit IgG Aff - Purified Hu P, WB
0.1 mg / €470.00
  Novus Biologicals Inc.

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