Cathepsin B antibody

Principal name

Cathepsin B antibody

Alternative names for Cathepsin B antibody

Cathepsin B1, APP secretase, APPS, CTSB, CPSB

SwissProt ID

A1E295 (Pig), P00787 (Rat), P07688 (Bovin), P07858 (Human), P10605 (Mouse)

Gene ID

1508 (CTSB), 13030 (Ctsb)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Goat, Mouse, Sheep

Available applications

Flow Cytometry (F), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunodiffusion (ID), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Cathepsin B antibody

Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene.1, 2 And this gene is mapped to chromosome 8p22.3 The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease.4 Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. The standard product used in this kit is recombinant human Cathepsin B with the molecular mass of 37KDa.

General readings

Podgorski I., et al. (2003) Biochem Soc Symp. 70:263-276.Roshy S., et al. (2003) Cancer Metastasis Rev. 22:271-286.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cathepsin B antibody

Cells were scratch-wounded and stained against cathepsin B and annexin-II heterotetramer subunit p11 after 1 (a), 8 (b) and 24 (c) hours. Fixation was performed with both -20oC cold methanol and acetone for 8 minutes each. Cathepsin B is shown in red, p11 is shown in green. Goat Aff - Purified Ms C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

Cathepsin B antibody

  Rabbit Polyclonal Cathepsin B Antibody  
Western Blot: Cathepsin B Antibody [TA336744] - extracts from COLO cells. Rabbit Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin B antibody

  Anti-CTSB Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/150-500  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CTSB antibody at dilution 1/140, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin B antibody

  Anti-CTSB Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human lung cancer tissue. Recommended dilution: 1/50-100  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CTSB antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin B Control Peptide

Cathepsin B Purified
50 µg / €180.00
  Acris Antibodies GmbH

Cathepsin B antibody

Western blot analysis of Cathepsin B with Jurkat cell (Lane 1) and mouse small intestine tissue (Lane 2) lysate. Rabbit Purified Hu, Ms, Rt F, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cathepsin B antibody

Immunohistochemistry analysis of Cathepsin B Antibody (Cat.-No.: AP20651PU-N) in Paraffin-Embedded Human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cathepsin B antibody

Cathepsin B Mouse IgG2b CB131 Supernatant Hu P
1 ml / €530.00
  Acris Antibodies GmbH

Cathepsin B antibody

Cathepsin B Sheep Purified Hu ID, WB
1 ml / €430.00
  Acris Antibodies GmbH

Cathepsin B antibody

Cathepsin B Goat Aff - Purified Hu WB
0.1 mg / €450.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

CTSB - human gene knockout kit via CRISPR

CTSB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CTSB - human gene knockout kit via CRISPR

CTSB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CTSB - human gene knockout kit via CRISPR

CTSB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CTSB - human gene knockout kit via CRISPR

CTSB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ctsb - mouse gene knockout kit via CRISPR

Ctsb - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ctsb - mouse gene knockout kit via CRISPR

Ctsb - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ctsb - mouse gene knockout kit via CRISPR

Ctsb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ctsb - mouse gene knockout kit via CRISPR

Ctsb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cathepsin B (transcript variant 5)

  Recombinant protein of human cathepsin B (CTSB), transcript variant 5  
Cathepsin B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Cathepsin B (transcript variant 1)

  Recombinant protein of human cathepsin B (CTSB), transcript variant 1  
Cathepsin B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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