Cathepsin D antibody

Principal name

Cathepsin D antibody

Alternative names for Cathepsin D antibody

CTSD, CPSD

SwissProt ID

P00795 (Pig), P07339 (Human), P18242 (Mouse), P24268 (Rat), P80209 (Bovin), Q05744 (Chick)

Gene ID

1509 (CTSD), 13033 (Ctsd)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Mky (Monkey), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Cathepsin D antibody

Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins.
In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer and possibly Alzheimer's disease.

General readings

1 Hasilik, A.; von Figura, K.; Grzeschik, K.-H. : Assignment of a gene for human cathepsin D to chromosome 11. (Abstract) Cytogenet. Cell Genet. 32: 284 only, 1982.
2 Qin, S.; Nakai, H.; Byers, M. G.; Eddy, R. L.; Haley, L. L.; Henry, W. M.; Wang, X.; Watkins, P. C.; Chirgwin, J. M.; Shows, T. B. : Mapping FSHB, CAT, and CTSD to specific sites on 11p. (Abstract) Cytogenet. Cell Genet. 46: 678 only, 1987.
3 Faust, P. L.; Kornfeld, S.; Chirgwin, J. M. : Cloning and sequence analysis of cDNA for human cathepsin D. Proc. Nat. Acad. Sci. 82: 4910-4914, 1985.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cathepsin D antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-CTSD Rabbit Polyclonal antibody. (TA590104) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Immunohistochemistry: AM09003PU-N Cathepsin D antibody staining of Formalin-Fixed, Paraffin-Embedded Human Tonsil at 5 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. Mouse IgG2b 4G2 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Cathepsin D antibody

Immunohistochemistry: AM09003PU-N Cathepsin D antibody staining of Formalin-Fixed, Paraffin-Embedded Human Tonsil at 5 µg/ml followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. Mouse IgG2b 4G2 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

Cathepsin D (26-412) antibody

Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 3F12-1B9 Purified Hu E, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Cathepsin D (C-term) antibody

Cathepsin D Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

Cathepsin D (C-term) antibody

Cathepsin D Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt C, ICC/IF, P, WB
0.6 mg / €320.00
  SICGEN

Cathepsin D (C-term) antibody

Cathepsin D Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt C, ICC/IF, P, WB
1.5 mg / €450.00
  SICGEN

Cathepsin D antibody

Human breast carcinoma stained with anti-cathepsin D antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

Cathepsin D antibody

Human breast carcinoma stained with anti-cathepsin D antibody Rabbit Purified Hu P
1 ml / €490.00
  Acris Antibodies GmbH

Cathepsin D antibody

Human breast carcinoma stained with anti-cathepsin D antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

Cathepsin D antibody

Cathepsin D Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Western blot analysis of extracts from COS-7 cells, treated with etoposide (25uMl, 1hour), using CATD (light chain, Cleaved-Gly65) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Western blot analysis of extracts from 293 cellstreated with etoposide (25uM, 1hour), Jurkat cells and A549 cells treated with etoposide (25uM, 24hours), using CATD (heavy chain, Cleaved-Leu169) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Western blot analysis of extracts from K562 cells, using CATD (light chain, Cleaved-Gln161) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Western blot analysis of extracts from HeLa cells, using CTSD antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

CTSD Antibody(Cat. #TA324903) western blot analysis in MCF-7,U251,HepG2 cell line lysates (35ug/lane).This demonstrates the CTSD antibody detected the CTSD protein (arrow). Mouse IgG1 892CT11.1.1 Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Western blot analysis of extracts of various cell lines, using CTSD antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cathepsin D antibody

Cathepsin D Mouse IgG2a CP-D13 Aff - Purified Hu IP, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Cathepsin D antibody

Immunohistochemistry (IHC) analyzes of Cathepsin D antibody (Cat.-No.: AP20767PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cathepsin D antibody

Human Liver (formalin-fixed, paraffin-embedded) stained with CTSD antibody AP22696PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu P
50 µg / €470.00
  Acris Antibodies GmbH

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