Cathepsin L1 antibody

Principal name

Cathepsin L1 antibody

Alternative names for Cathepsin L1 antibody

CTSL1, CTSL, MEP, Cathepsin-L1, Major excreted protein

SwissProt ID

P06797 (Mouse), P07154 (Rat), P07711 (Human), P09648 (Chick), P25773, P25975 (Bovin), Q10991, Q28944, Q9GL24

Gene ID

1514 (CTSL1), 13039 (Ctsl), 25697 (Ctsl1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Md (Mustelid), Mink

Available hosts

Goat, Mouse, Rabbit, Rat

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Cathepsin L1 antibody

Cathepsin L is closely related to the recently described cathepsin V (L2) and the sequence indentity of almost 80% between them requires antibodies for the detection of cathepsin L which do not crossreact with cathepsin V. This requirement can only be met by epitope specific monoclonal antibodies as are used in BMS257. Cathepsin L is a lysosomal cysteine proteinase consisting of a heavy chain of about 25 kDa and a light chain of about 5 kDa derived proteolytically from the same precursor. Cathepsin L has been shown to be produced by many different cell types. Since cathepsin L is capable of degrading protein constituents of the extracellular matrix it is assumed to play a crucial role in tumor progression and metastasis and a number of other disorders where the destruction of the extracellular matrix is the major cause of disease (e.g. rheumatoid arthritis, neurodegeneration).

General readings

Zheng X, et al: (2009) Am J Physiol Cell Physiol. 65-74
Reinheckel T, et al: (2005) J Cell Sci. , 3387-95
Ishidoh K, Kominami E: (2002) Biol chem. 1827-31
Roth W, et al: (2000) FASEB J. 2075-86

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cathepsin L1 antibody

Immunohistochemistry: AM09006PU-N Cathepsin L antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate at 5 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG2b 2H7 Purified Hu E, P, WB
0.1 ml / €310.00
  Acris Antibodies GmbH

Cathepsin L1 antibody

Immunohistochemistry: AM09006PU-N Cathepsin L antibody staining of Formalin-Fixed, Paraffin-Embedded Human Prostate at 5 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG2b 2H7 Purified Hu E, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

Cathepsin L1 antibody

Western blot analysis of extracts from HeLa cells, treated with etoposide (25uM, 1hour), using CATL1 (heavy chain, Cleaved-Thr288) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cathepsin L1 antibody

Western blot analysis of Cathepsin L expression with Jurkat cell lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cathepsin L1 antibody

Cathepsin L1 Mouse IgG CP-L14 Aff - Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Cathepsin L1 Control Peptide

Cathepsin L1 Purified
50 µg / €190.00
  Acris Antibodies GmbH

Cathepsin L1 antibody

Cathepsin L1 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

Western Blot analysis of CTSL1 expression in transfected 293T cell line (H00010135-T03) by CTSL1 MaxPab polyclonal antibody.

Lane 1: CTSL1 transfected lysate(37.60 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

Cathepsin L1 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

CTSL1 MaxPab rabbit polyclonal antibody. Western Blot analysis of CTSL1 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

Cathepsin L1 Mouse IgG1 CP-L14 Hu, Ms, Rt C, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

The recombinant fusion proteins and cell lysate were resolved by SDS-PAGE and probed with CTSL1 monoclonal antibody, clone 2H7 ( Cat # MAB2047 ) ( 1:1000 ).
Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Lane 1 : CTSB.
Lane 2 : CTSD.
Lane 3 : CTSK.
Lane 4 : CTSL1.
Lane 5 : CTSS.
Lane 6 : A-549. Mouse IgG2b 2H7 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

Western blot analysis of Ctsl1 expression in rat kidney tissue lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Cathepsin L1 antibody

Western blot analysis of CTSL1 expression in Jurkat cell lysate. Rabbit Hu, Ms, Rt WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Cathepsin L1 (cleaved) antibody

Western blot analysis of extracts from HeLa cells, treated with etoposide 25uM 1h, using CATL1 (heavy chain,Cleaved-Thr288) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

Cathepsin L1 (cleaved) antibody

Western blot analysis of extracts from HeLa cells, treated with etoposide 25uM 1h, using CATL1 (heavy chain,Cleaved-Thr288) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

Cathepsin L1 antibody

Cathepsin L1 Mouse IgG1 CP-L14 Ascites Hu, Ms, Rt C, WB
0.1 mg / €290.00
  Boster Immunoleader

Cathepsin L1 antibody

Cathepsin L1 Goat Aff - Purified Hu C, ICC/IF, WB
0.1 mg / €450.00
  Neuromics Antibodies

Cathepsin L1 antibody

Cathepsin L staining of perfusion fixed frozen sections of mouse ovary (15 µg/mL) overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue). Goat Aff - Purified Ms C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

Cathepsin L1 antibody

Western blot: Cathepsin L antibody (33/2) [NB100-1775] - Whole cell extract of Mv 1 Lu cultured mink lung was separated on SDS-PAGE and blotted with Monoclonal Anti-Cathepsin L. The antibody was developed with Goat Anti-Mouse IgG (Fab), AlkPhos Conjugate and NBT/BCIP substrate. Lane A: Antibody dilution 1:400. Lane B: Negative control (only secondary antibody). Mouse IgG1 33/2 Ascites Hu, Md, Ms, Rt C, E, P, WB
0.1 ml / €340.00
  Novus Biologicals Inc.

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