Alternative names for CATSPER4 antibody
Cation channel sperm-associated protein 4
Frozen Sections (C), Paraffin Sections (P), Western blot / Immunoblot (WB)
Background of CATSPER4 antibody
During mammalian fertilization, Ca2+ sigling plays a central role in sperm capacitation and motility to the fusion between sperm and egg. Several Ca2+-permeable ion channel proteins have been characterized in mammalian sperm. However, only the four mammalian CatSper members (CatSpers 1-4) are restrictively expressed in the testis and are clearly shown to be required for male fertility. CatSper channels are med after the first putative cation channel of sperm. CatSper4 contains a single ion transport domain comprised of 6 transmembrane spanning regions, where the fourth transmembrane region resembles a voltage sensor and a pore forming region lies between transmembrane regions 5 and 6. The pore contains the consensus sequence TÃ?DÃ?W indicative of a probable Ca2+ selective channel. The four CatSper proteins are primarily localized to the plasma membrane of the distal portion of the sperm tail and presumably form a heterotetrameric, pH- and voltage-dependent Ca2+-permeable channel . CatSper 4 is highly expressed in testis and expressed at low levels in placenta and lung. Male mice deficient in any of the four CatSper are completely sterile but exhibit no other apparent abnormality. The major phenotypes of the sperm are a lack of hyperactivated motility, a gradual loss of motility after isolation, and an ibility to penetrate zo-intact eggs.