CBFB antibody

Principal name

CBFB antibody

Alternative names for CBFB antibody

Core-binding factor beta, CBF-beta, CBF beta, PEBP2-beta, PEA2-beta, Polyomavirus enhancer-binding protein 2 beta subunit, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit

SwissProt ID

Q08024 (Mouse), Q13951 (Human)

Gene ID

865 (CBFB), 12400 (Cbfb)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of CBFB antibody

The transcription factor Polyomavirus enhancer binding protein 2 (PEBP2), also designated Osf2 (Osteoblast-specific transcription factor), CBFA1 (Core Binding Factor) and AML3 (Acute myeloid leukemia), is composed of two subunits, alpha and beta, which are essential for the regulation of hematopoiesis and osteogenesis. The PEBP2alpha subunits, PEBP2alphaA, PEBP2alphaB and PEBP2alphaC, are encoded by three RUNX genes, all of which contain a 128-amino acid region homologous to the highly conserved Drosophila segmentation gene, runt. This region is involved in DNA binding and heterodimerization with the regulatory beta subunit, which facilitates DNA binding of the alpha subunit. Both subunits are required for in vivo function; the disruption of either gene results in a lack of definitive hematopoiesis followed by embryo death in utero due to hemorrhage in the central nervous system. The gene encoding PEBP2beta is the target of chromosomal inversion 16 (p13;q22) with the smooth muscle myosin heavy chain, producing a chimeric gene, PEBP2beta/CBFbeta-SMMHC, that is associated with human acute myeloid leukemia.

General readings

Speck NA., et al. (2009) Blood. 113(13):3070-9.
Ito Y., et al. (2008) Blood. 112(9):3777-87.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CBFB antibody

  Rabbit polyclonal anti-CBF beta antibody  
Western blot analysis of extracts from HeLa cells and HUVEC cells, using CBF ß antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Rabbit polyclonal anti-PPP4R1L antibody  
Western blot analysis of extracts from HepG2 cells, COLO cells, Jurkat cells, HUVEC cells and COS cells, using PPP4R1L antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Goat Polyclonal CBFB Antibody  
Anti-CBFB (0.3ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Rabbit polyclonal CBFB Antibody (Center)  
CBFB Antibody (Center) (Cat. #TA324878) western blot analysis in K562 cell line and mouse lung tissue lysates (35ug/lane).This demonstrates the CBFB antibody detected the CBFB protein (arrow). Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Rabbit Polyclonal anti-CBFB Antibody  
Host: Rabbit; Target Name: CBFB; Sample Tissue: Jurkat Whole Cell lysates; Antibody Dilution: 1.0ug/mlCBFB is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Rabbit Polyclonal Anti-CBFB Antibody  
WB Suggested Anti-CBFB Antibody Titration: 0.2-1 ug/ml; Positive Control: K562 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Rabbit anti-CBFB Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CBFB antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBFB antibody

  Rabbit Polyclonal CBFb Antibody  
ChIP assays were performed using SKNO-1 cells, the antibody against CBFb and optimized primer pairs for qPCR. Sheared chromatin from 1.25 million cells and 4 ul of antibody were used per ChIP experiment. QPCR was performed using primers specific for the FUT7, OGG1, NFE2, and SPI1 genes. Image shows the relative occupancy, calculated as the ratio + control/background for which the MYOG gene was used. Rabbit IgG Purified Hu E
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBFB antibody

Immunohistochemistry (IHC) analyzes of PEBP2beta antibody (Cat.-No.: AP202442PU-N) in paraffin-embedded human heart tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CBFB antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using CBF beta Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

CBFB antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using CBF beta Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CBFB - human gene knockout kit via CRISPR

CBFB - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CBFB - human gene knockout kit via CRISPR

CBFB - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBFB - human gene knockout kit via CRISPR

CBFB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBFB - human gene knockout kit via CRISPR

CBFB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cbfb - mouse gene knockout kit via CRISPR

Cbfb - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cbfb - mouse gene knockout kit via CRISPR

Cbfb - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cbfb - mouse gene knockout kit via CRISPR

Cbfb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cbfb - mouse gene knockout kit via CRISPR

Cbfb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CBFB (transcript variant 2)

  Recombinant protein of human core-binding factor, beta subunit (CBFB), transcript variant 2  
CBFB Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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