CBLB / RNF56 antibody

Principal name

CBLB / RNF56 antibody

Alternative names for CBLB / RNF56 antibody

CBL-B, RING finger protein 56, E3 ubiquitin-protein ligase CBL-B, Casitas B-lineage lymphoma proto-oncogene b, SH3-binding protein CBL-B, Signal transduction protein CBL-B

SwissProt ID

Q13191 (Human), Q3TTA7 (Mouse), Q8K4S7 (Rat)

Gene ID

868 (CBLB), 208650 (Cblb), 171136

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CBLB / RNF56 antibody

The Casitas B lineage lymphoma (Cbl) proteins (in mammals these are c-Cbl, Cbl-b, and Cbl-c) are a family of single subunit RING finger protein-ubiquitin E3 ligases that contain multiple protein interaction motifs. All Cbl proteins have a highly conserved N-termil tyrosine kise-binding (TKB) domain that mediates interactions between Cbl proteins and phosphorylated tyrosine residues on Cbl substrates. C-termil to the RING finger, Cbl proteins have proline-rich domains that mediate interactions with SH3 domain-containing proteins. Phosphorylated tyrosine residues mediate interactions with SH2 domain-containing proteins such as the p85 subunit of PI3K. These protein-protein interaction motifs allow Cbl family proteins to function as adaptor proteins. This adaptor function contributes to the E3-dependent activities of Cbl proteins by targeting specific substrates for ubiquitition and degradation. The adaptor function also contributes to non-E3-dependent activities, such as the recruitment of proteins involved in receptor tyrosine kise interlization, localization of Cbl proteins to specific subcellular compartments, and activation of discrete sigling pathways. Cbl-b is an E3 ubiquitin ligase with a domain organization nearly identical to that of c-Cbl. The role of Cbl-b in hematopoietic cell physiology is well documented. Cbl-b expression is important for the downregulation of TCR expression during antigen recognition. Cbl-b also acts as a potent negative regulator of the CD28 sigling cascade to Vav and Rac1 through its ability to ubiquitite the p85 regulatory subunit of PI3K. As a critical regulator of clol anergy in T lymphocytes, Cbl-b mR and protein are upregulated in T cells following calcium mobilization and calcineurin activation. Cbl-b-deficient T cells are resistant to anergy induction. The molecular events governing this phenotype are thought to be linked to defects in the ubiquitition of PLC?1 and PKC? since the degradation of these sigling molecules, which occurs following restimulation of wild-type anergic T cells, fails to occur in Cbl-b-deficient T cells.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CBLB / RNF56 antibody

  Rabbit Polyclonal CBLB Antibody  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-CBLB rabbit polyclonal antibody. (TA590305) Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBLB / RNF56 antibody

  CBLB Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CBLB antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBLB / RNF56 (Center) antibody

Western blot analysis of CBLB Antibody (Center) (AP17925PU-N) in HL-60 cell line lysates (35ug/lane). CBLB (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CBLB - human gene knockout kit via CRISPR

CBLB - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBLB - human gene knockout kit via CRISPR

CBLB - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cblb - mouse gene knockout kit via CRISPR

Cblb - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cblb - mouse gene knockout kit via CRISPR

Cblb - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cblb - mouse gene knockout kit via CRISPR

Cblb - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cblb - mouse gene knockout kit via CRISPR

Cblb - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CBLB / RNF56

  Recombinant protein of human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB)  
CBLB / RNF56 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CBLB / RNF56

CBLB / RNF56 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CBLB / RNF56

CBLB / RNF56 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

CBLB / RNF56

CBLB / RNF56 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CBLB / RNF56

CBLB / RNF56 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CBLB (mGFP-tagged) - Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB), 200 uL, >10^7 TU/mL

Lenti ORF particles, CBLB (mGFP-tagged) - Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CBLB (Myc-DDK tagged) - Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CBLB (Myc-DDK tagged) - Human Cas-Br-M (murine) ecotropic retroviral transforming sequence b (CBLB) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cblb (GFP-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cblb (GFP-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb), 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cblb (Myc-DDK-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cblb (Myc-DDK-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb), 200 uL, >10^7 TU/mL  
200 µl / €1,530.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cblb (GFP-tagged ORF) - Rat Cas-Br-M (murine) ecotropic retroviral transforming sequence b (Cblb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cblb (GFP-tagged ORF) - Rat Cas-Br-M (murine) ecotropic retroviral transforming sequence b (Cblb), 200 uL, >10^7 TU/mL  
200 µl / €1,700.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cblb (Myc-DDK-tagged ORF) - Rat Cas-Br-M (murine) ecotropic retroviral transforming sequence b (Cblb), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cblb (Myc-DDK-tagged ORF) - Rat Cas-Br-M (murine) ecotropic retroviral transforming sequence b (Cblb), 200 uL, >10^7 TU/mL  
200 µl / €1,527.00
  OriGene Technologies, Inc.

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