CBLL1 / RNF188 antibody

Principal name

CBLL1 / RNF188 antibody

Alternative names for CBLL1 / RNF188 antibody

HAKAI, c-Cbl-like protein 1, RING finger protein 188, E3 ubiquitin-protein ligase Hakai, Casitas B-lineage lymphoma-transforming sequence-like protein 1

SwissProt ID

Q4V7X9 (Xenla), Q5ZHZ4 (Chick), Q75N03 (Human), Q9JIY2 (Mouse)

Gene ID

79872 (CBLL1), 3779872 (galK)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of CBLL1 / RNF188 antibody

CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.

General readings

Strausberg,R.L., (2004) J. Cell. Sci. 117 (PT 7), 989-998

15 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CBLL1 / RNF188 antibody

WB Suggested Anti-CBLL1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CBLL1 / RNF188 antibody

WB Suggested Anti-CBLL1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: COLO205 cell lysate Rabbit IgG Purified GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CBLL1 / RNF188 antibody

WB Suggested Anti-CBLL1 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBLL1 / RNF188 antibody

CBLL1 / RNF188 Rabbit IgG Purified Hu C, ICC/IF, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CBLL1 / RNF188 antibody

CBLL1 / RNF188 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CBLL1 / RNF188 antibody

Immunofluorescence of monoclonal antibody to CBLL1 on HeLa cell . [antibody concentration 10 ug/ml] Mouse IgG2a 4C2 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CBLL1 / RNF188 antibody

CBLL1 / RNF188 Mouse IgG2a 3B12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CBLL1 / RNF188 antibody

Human THP-1; WB Suggested Anti-CBLL1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: THP-1 cell lysate; CBLL1 antibody - N-terminal region (ARP33601_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified African clawed frog, Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CBLL1 / RNF188 antibody

Human COLO205; WB Suggested Anti-CBLL1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: COLO205 cell lysate; CBLL1 antibody - N-terminal region (ARP39622_P050) in Human COLO205 cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CBLL1 / RNF188 antibody

Human HepG2; WB Suggested Anti-CBLL1 Antibody Titration: 1.25ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; CBLL1 antibody - C-terminal region (ARP39623_T100) in Human HepG2 cells using Western Blot Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

CBLL1 / RNF188 antibody

Immunohistochemistry-Paraffin: CBLL1 Antibody [NBP1-83588] Immunohistochemical staining of human gall bladder shows strong nuclear positivity in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

CBLL1 / RNF188 antibody

Immunohistochemistry-Paraffin: CBLL1 Antibody [NBP1-83589] Immunohistochemical staining of human cerebellum shows strong nuclear positivity in Purkinje cells, cells in molecular layer and cells in granular layer. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CBLL1 / RNF188

CBLL1 / RNF188 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CBLL1 / RNF188

CBLL1 / RNF188 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

CBLL1 overexpression lysate

CBLL1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

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