CBX1 antibody

Principal name

CBX1 antibody

Alternative names for CBX1 antibody

Chromobox protein homolog 1, M31, Heterochromatin protein p25, HP1Hsbeta, p25beta, HP1-beta, HP1 beta, Heterochromatin protein 1 homolog beta, Modifier 1 protein

SwissProt ID

P83916 (Human), P83917 (Mouse)

Gene ID

10951 (CBX1), 12412 (Cbx1)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Dros (Drosophila), Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), L (Lizard), Bear, Ze (Zebrafish), African clawed frog, Eq (Equine), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), ChIP assay (ChIP), Immunofluorescence (IF)

Background of CBX1 antibody

Heterochromatin Protein 1 (HP1) ("Chromobox Homolog", CBX) includes three isoforms in mammals, designated α, β, and γ. HP1 proteins are approximately 25 kDa in size. They are highly conserved adapter proteins with important regulatory functions in the cell nucleus. These functions include notably gene silencing by heterochromatin formation. HP1 proteins are fundamental units of heterochromatin packaging that are enriched at the centromeres and telomeres of nearly all Eukaryotic chromosomes. HP1 β and γ also localize to euchromatic sites in the genome. Members of the HP1 family are characterized by an N-terminal chromodomain and a C- terminal chromoshadow domain, separated by a Hinge region. Chromodomain and chromoshadow domain establish secondary interactions with a large number of other proteins. HP1 proteins are subject to multiple types of post - translational modifications, including phosphorylation, acetylation, methylation, ubiquitination and sumoylation, suggesting multiple means of regulation.

General readings

Sharma GG, Hwang KK, Pandita RK, Gupta A, Dhar S, Parenteau J, Agarwal M, Worman HJ, Wellinger RJ, Pandita TK. Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. Mol Cell Biol. 2003 Nov;23(22):8363-76.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CBX1 antibody

  Goat Polyclonal Antibody against CBX1  
TA303064 (0.3µg/ml) staining of A431 lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBX1 antibody

  Rabbit Polyclonal Anti-CBX1 Antibody  
WB Suggested Anti-CBX1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: OVCAR-3 cell lysateCBX1 is supported by BioGPS gene expression data to be expressed in OVCAR3 Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CBX1 antibody

  Rabbit Polyclonal Anti-CBX1 Antibody  
WB Suggested Anti-CBX1 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBX1 antibody

  Rabbit Polyclonal Anti-CBX1 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using (CBX1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBX1 antibody

Immunofluorescence analysis of Hela cells using CBX1 antibody Cat.-No AM06468SU-N (green). Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 5A3 Ascites Hu, Mky E, F, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CBX1 antibody

Immunohistochemistry on paraffin sections: Human brain cortex stained with AM26739PU-N. Mouse IgG1 1MOD-1A9 Purified Hu, Ms, Por P
0.1 mg / €440.00
  Acris Antibodies GmbH

CBX1 antibody

Detection of Human HP1 beta in HeLa whole cell lysate using Rabbit anti Human HP1 beta (AP05722PU-N) Goat IgG Purified Hu, Ms WB
50 µg / €330.00
  Acris Antibodies GmbH

CBX1 (69-81) antibody

Figure 1. Immunohistochemical analysis of Formalin-Fixed Paraffin-Embedded Human Placenta tissue using AP08785PU-N at 2.5 µg/ml. Goat IgG Aff - Purified Bear, Bt, Can, Elephant, Hst, Hu, L, Mky, Ms, Op, Platypus, Por, Prim, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CBX1 - human gene knockout kit via CRISPR

CBX1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CBX1 - human gene knockout kit via CRISPR

CBX1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBX1 - human gene knockout kit via CRISPR

CBX1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBX1 - human gene knockout kit via CRISPR

CBX1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cbx1 - mouse gene knockout kit via CRISPR

Cbx1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cbx1 - mouse gene knockout kit via CRISPR

Cbx1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cbx1 - mouse gene knockout kit via CRISPR

Cbx1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cbx1 - mouse gene knockout kit via CRISPR

Cbx1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CBX1 (transcript variant 1)

  Recombinant protein of human chromobox homolog 1 (HP1 beta homolog Drosophila ) (CBX1), transcript variant 1  
CBX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CBX1 (transcript variant 2)

  Recombinant protein of human chromobox homolog 1 (HP1 beta homolog Drosophila ) (CBX1), transcript variant 2  
CBX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CBX1 (1-185, His-tag)

CBX1 Human Purified > 85 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

CBX1 (1-185, His-tag)

CBX1 Human Purified > 85 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

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