CBX4 / PC2 antibody

Principal name

CBX4 / PC2 antibody

Alternative names for CBX4 / PC2 antibody

Chromobox protein homolog 4, Polycomb 2 homolog, E3 SUMO-protein ligase CBX4

SwissProt ID

O00257 (Human), O55187 (Mouse)

Gene ID

8535 (CBX4), 12418 (Cbx4)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of CBX4 / PC2 antibody

PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.

General readings

Simon JA and Tamkun JW. Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Curr. Opin. Genet. Dev. 2002;12:210-8.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CBX4 / PC2 antibody

  Rabbit anti-CBX4 polyclonal antibody  
Western blot analysis of HEK293 cell lysates with anti-CBX4 antibody diluted at 1:250. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

  Rabbit polyclonal anti-CBX4 antibody (NT)  
Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit Purified Hu, Ms, Rt E, WB
0.1 mg / €345.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

  Rabbit polyclonal anti-PC2 antibody  
Analysis shows the detection of human PC2 in probed lysates using Affinity Purified anti-hPC2 antibody. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

CBX4 / PC2 (N-term) antibody

  Rabbit Polyclonal CBX4 Antibody  
Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

  Rabbit Polyclonal anti-CBX4 antibody  
WB Suggested Anti-CBX4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysateCBX4 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

  Rabbit Polyclonal CBX4 Antibody  
Determination of the antibody titer To determine the titer of the antibody, an ELISA was performed using a serial dilution of the antibody against human CBX4. The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 1), the titer of the antibody was estimated to be 1:11,250. Rabbit IgG Purified Hu E
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 (95-107) antibody

Colon: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CBX4 / PC2 (N-term) antibody

Figure 2. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CBX4 / PC2 (C-term) antibody

The anti-CBX4 (C-term) Pab (Cat.#AP12234PU-N) is used in Western blot to detect CBX4 in Jurkat cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CBX4 - human gene knockout kit via CRISPR

CBX4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CBX4 - human gene knockout kit via CRISPR

CBX4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBX4 - human gene knockout kit via CRISPR

CBX4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CBX4 - human gene knockout kit via CRISPR

CBX4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cbx4 (GFP-tagged) - Mouse chromobox homolog 4 (Drosophila Pc class) (Cbx4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cbx4 (GFP-tagged) - Mouse chromobox homolog 4 (Drosophila Pc class) (Cbx4), 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cbx4 (Myc-DDK-tagged) - Mouse chromobox homolog 4 (Drosophila Pc class) (Cbx4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cbx4 (Myc-DDK-tagged) - Mouse chromobox homolog 4 (Drosophila Pc class) (Cbx4), 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

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