CBX4 / PC2 antibody

Principal name

CBX4 / PC2 antibody

Alternative names for CBX4 / PC2 antibody

Chromobox protein homolog 4, Polycomb 2 homolog, E3 SUMO-protein ligase CBX4

SwissProt ID

O00257 (Human), O55187 (Mouse)

Gene ID

8535 (CBX4)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Dot blot (Dot)

Background of CBX4 / PC2 antibody

PC2 is the human homolog of the Drosophila 'Polycomb' (Pc) protein which has been identified as a gene family member associated with a cellular memory system that is responsible for the inheritance of gene activity by progeny cells. The human Pc homolog gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins are shown to colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. The human protein is believed to function as a repressor of proto-oncogene activity and that interference with hPc2 function can lead to derepression of proto-oncogene transcription and subsequently to cellular transformation. Other reports describe PC2 as a protein that has SUMO E3 activity for the corepressors CtBP and CtBP2.

General readings

Simon JA and Tamkun JW. Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Curr. Opin. Genet. Dev. 2002;12:210-8.

  1. Quick-Filters:
  2. Overnight Delivery (1)

19 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CBX4 / PC2 antibody

Western blot analysis of HEK293 cell lysates with anti-CBX4 antibody diluted at 1:250. Rabbit Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit Purified Hu, Ms, Rt E, WB
0.1 mg / €345.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

Analysis shows the detection of human PC2 in probed lysates using Affinity Purified anti-hPC2 antibody. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 (N-term) antibody

Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 antibody

Determination of the antibody titer To determine the titer of the antibody, an ELISA was performed using a serial dilution of the antibody against human CBX4. The plates were coated with the peptides used for immunization of the rabbit. By plotting the absorbance against the antibody dilution (Figure 1), the titer of the antibody was estimated to be 1:11,250. Rabbit IgG Purified Hu E
0.1 ml / €325.00
  OriGene Technologies, Inc.

CBX4 / PC2 (95-107) antibody

Colon: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CBX4 / PC2 (N-term) antibody

Figure 2. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Purified Hu, Ms P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

CBX4 / PC2 (C-term) antibody

The anti-CBX4 (C-term) Pab (Cat.#AP12234PU-N) is used in Western blot to detect CBX4 in Jurkat cell lysate. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CBX4 / PC2 (N-term) Control Peptide

Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody Cat.-No AP55488PU-N at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide 'Cat.-No. AP55488CP-N.
50 µg / €160.00
  Acris Antibodies GmbH

CBX4 / PC2 antibody

Western Blot analysis of CBX4 expression in transfected 293T cell line (H00008535-T01) by CBX4 MaxPab polyclonal antibody.

Lane 1: CBX4 transfected lysate(31.9 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CBX4 / PC2 antibody

CBX4 / PC2 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CBX4 / PC2 antibody

The CBX4 polyclonal antibody ( Cat # PAB1689 ) is used in Western blot to detect CBX4 in Jurkat cell lysate Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CBX4 / PC2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with CBX4 polyclonal antibody ( Cat # PAB1690 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

CBX4 / PC2 antibody

Immunofluorescence microscopy of CBX4 polyclonal antibody ( Cat # PAB10228 ) was used for immunofluorescent imaging of U-2 OS.
The image reveals the expected discrete nuclear structure that is termed the PcG body corresponding to the known localization of CBX4 ( see Satijn et al. below ) .
Primary antibody used at 1 : 200.
Data contributed by Luke Hughes-Davies and Rhiannon Jade, Gurdon Institute, Cambridge, UK. Hu, Ms
0.1 mg / €560.00
  Abnova Taiwan Corp.

CBX4 / PC2 antibody

Human kidney; Rabbit Anti-CBX 4 Antibody. Catalog Number: ARP30002. Paraffin Embedded Tissue: Human Kidney. Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X; CBX4 antibody - N-terminal region (ARP30002_P050) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

CBX4 / PC2 antibody

Western Blot: CBX4 Antibody [NBP1-31249] - Western blot analysis of CBX4 Antibody on: A: 293T 7.5% SDS PAGE diluted at 1:500 Rabbit IgG Hu Dot, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CBX4 / PC2 antibody

Immunohistochemistry-Paraffin: CBX4 Antibody [NBP1-83225] - Immunohistochemical staining of human stomach shows strong cytoplasmic and weak nuclear positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CBX4 / PC2

CBX4 / PC2 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CBX4 293T Cell Transient Overexpression Lysate(Denatured)

CBX4 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

19 Item(s)

per page
  • LinkedIn