CBX5 antibody
Principal name
CBX5 antibody
Alternative names for CBX5 antibody
Chromobox protein homolog 5, HP1A, p25, HP1 alpha, HP1-alpha, Heterochromatin protein 1 homolog alpha
Ncbi ID
NP_001120793.1, NP_036249, 9606, NP_001120794.1, NP_001120793, NP_001120794, NM_007626, NM_001127322, NM_001127321, NM_001110216, NM_012117
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), EPair for Elisa (EPair), ELISA (detection) (E(detection)), Immunofluorescence (IF), Immunoprecipitation (IP)
Background of CBX5 antibody
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functiol chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double- primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase. A molecular mechanism through which the SUV39H-HP1 methylation system can contribute to the propagation of heterochromatic subdomains in tive chromatin has been defined. It has been demonstrated that HP1 can bind with high affinity to histone H3 methylated at lysine-9 but not at lysine-4. The chromodomain of HP1 as its methyl-lysine-binding domain has been identified. A point mutation in the chromodomain, which destroys the gene silencing activity of HP1 in Drosophila, abolished methyl-lysine-binding activity. Genetic and biochemical alysis in S. pombe showed that the methylase activity of Clr4 (the SUV39H1 homolog) is necessary for the correct localization of Swi6 (the HP1 equivalent) at centromeric heterochromatin and for gene silencing. A stepwise model for the formation of a transcriptiolly silent heterochromatin: SUV39H1 places a methyl marker on histone H3, which is then recognized by HP1 through its chromodomain has been suggested. This model may also explain the stable inheritance of the heterochromatic state. SUV39H1 and HP1 are both involved in the repressive functions of the retinoblastoma protein. Rb associates with SUV39H1 and HP1 in vivo by mean
General readings
Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, Leid M, Schaeffer E. Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. J Virol. 2003 May;77(9):5415-27.


Lane1:HEK293T whole cell lysate
Lane2:Mouse spleen tissue lysate
Lane3:Rat spleen tissue lysate



































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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TA326926 | CBX5 antibody |
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Rabbit anti-CBX5 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
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Highly validated antibody! |
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TA301513 | CBX5 antibody |
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Rabbit Polyclonal Antibody against HP 1 alpha | |||||||
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Rabbit | IgG | Purified | Hu | WB |
0.1 ml /
€416.00
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OriGene Technologies, Inc. | |||||||
TA302445 | CBX5 antibody |
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Goat Polyclonal Antibody against CBX5 / HP1-Alpha | |||||||
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Goat | Aff - Purified | Can, Hu, Ms | P, WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA312347 | CBX5 antibody |
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Rabbit polyclonal HP1 alpha (Ab-92) antibody | |||||||
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Rabbit | IgG | Purified | Hu | ICC/IF, P, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA312348 | CBX5 antibody |
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Rabbit polyclonal HP1a (Ser92) antibody(Phospho-specific) | |||||||
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Rabbit | IgG | Purified | Hu | E, P |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA323817 | CBX5 antibody |
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Anti-CBX5 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA323818 | CBX5 antibody |
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Anti-CBX5 Rabbit Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | E, WB |
0.1 ml /
€335.00
|
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OriGene Technologies, Inc. | |||||||
TA326263 | CBX5 antibody |
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Rabbit polyclonal CBX5 antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms | WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA330563 | CBX5 antibody |
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Rabbit Polyclonal Anti-CBX5 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, Hu, Ms, Por, Rb, Rt, Sh | ICC/IF, WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
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TA346905 | CBX5 antibody |
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Mouse Monoclonal HP1 alpha Antibody | |||||||
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Mouse | IgG2b | 3G2-H10-A6 | Purified | ICC/IF, WB |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA347090 | CBX5 antibody |
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Rabbit Polyclonal HP1alpha Antibody | |||||||
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Rabbit | IgG | Purified | Hu |
50 µg /
€392.00
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OriGene Technologies, Inc. | |||||||
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TA347091 | CBX5 antibody |
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Rabbit Polyclonal HP1alpha/beta/gamma Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms |
50 µg /
€392.00
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OriGene Technologies, Inc. | |||||||
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TA347092 | CBX5 antibody |
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Rabbit Polyclonal HP1 alpha Antibody | |||||||
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Rabbit | IgG | Purified | Hu |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
TA347093 | CBX5 antibody |
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Rabbit Polyclonal HP1 alpha, beta and gamma Antibody | |||||||
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Rabbit | IgG | Purified | Hu |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
AP06694PU-N | CBX5 antibody |
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Rabbit | Aff - Purified | Hu, Ms | ICC/IF, P, WB |
0.1 mg /
€350.00
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Acris Antibodies GmbH | |||||||
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AP08784PU-N | CBX5 (88-102) antibody |
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Goat | IgG | Aff - Purified | Bov, Elephant, Eq, Hu, Mky, Por, Sh | E, P, WB |
50 µg /
€380.00
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Acris Antibodies GmbH | |||||||
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AP55795PU-N | CBX5 pSer92 antibody |
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Rabbit | Aff - Purified | Hu | P |
0.1 mg /
€340.00
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Acris Antibodies GmbH | |||||||
AP55795PU-S | CBX5 pSer92 antibody |
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Rabbit | Aff - Purified | Hu | P |
50 µg /
€270.00
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Acris Antibodies GmbH | |||||||
A8262-1 | CBX5 pSer92 antibody |
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Rabbit | Aff - Purified | Hu | E, P |
50 µg /
€230.00
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Assay Biotech | |||||||
A8262-2 | CBX5 pSer92 antibody |
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Rabbit | Aff - Purified | Hu | E, P |
0.1 mg /
€330.00
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Assay Biotech |