Alternative names for CCAR1 antibody
CARP1, DIS, Cell division cycle and apoptosis regulator protein 1, Cell cycle and apoptosis regulatory protein 1, Death inducer with SAP domain
Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF)
Background of CCAR1 antibody
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
Kim JH, Yang CK, Heo K, Roeder RG, An W, Stallcup MR, CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Molecular cell 2008 Aug 31 (4): 510-9.