CCDC98 antibody

Principal name

CCDC98 antibody

Alternative names for CCDC98 antibody

Protein FAM175A, ABRA1, Abraxas, Coiled-coil domain-containing protein 98, BRCA1-A complex subunit Abraxas

SwissProt ID

Q5E9P1 (Bovin), Q5I0F1 (Rat), Q6UWZ7 (Human), Q8BPZ8 (Mouse)

Gene ID

84142 (FAM175A)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Flow Cytometry (F), Frozen Sections (C)

Background of CCDC98 antibody

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CCDC98 (N-term) antibody

Western blot analysis of CCDC98 in human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CCDC98 (N-term) antibody

Detection of ABRA1-EGFP fusion protein in lysate of transfected HEK293 cells.
Lane A: Immunostaining with anti-ABRA1 (clone ABRA1-01)
Lane B: Immunostaining with anti-EGFP (polyclonal)
Lane C: Immunostaining with anti-alpha tubulin (clone TU-01) Mouse IgG ABRA1-01 Aff - Purified Hu F, IP, P, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

CCDC98 Control Peptide

CCDC98
50 µg / €160.00
  Acris Antibodies GmbH

CCDC98 antibody

Immunohistochemistry of FAM175A in human breast tissue with FAM175A polyclonal antibody ( Cat # PAB13010 ) at 5 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CCDC98 antibody

Western Blot and Immunoprecipitation:Abraxas Antibody[NBP1-22977]- Whole cell lysate from HeLa and 293T cells. Abraxas was also immunoprecipitated by rabbit anti-Abraxas antibody NBP1-22978. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

CCDC98 antibody

Western Blot: Abraxas Antibody [NBP1-22978]-  Whole cell lysate from HeLa cells.  Affinity purified rabbit anti-Abraxas antibody used for IP at 10 mcg/mg lysate. Antibody was also immunoprecipitated by rabbit anti-Abraxas antibody NBP1-22977. Rabbit IgG Aff - Purified Hu IP, P
0.1 mg / €440.00
  Novus Biologicals Inc.

CCDC98 antibody

CCDC98 Mouse IgG ABRA1-01 Purified Hu F, IP, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

CCDC98 antibody

Immunohistochemistry-Paraffin: FAM175A Antibody [NBP1-76827] - Human breast tissue with CCDC98 antibody at 5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

CCDC98 antibody

Immunohistochemistry-Paraffin: FAM175A Antibody [NBP1-89298] - Immunohistochemical staining of human testis shows moderate nuclear positivity in seminiferous tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

FAM175A overexpression lysate

FAM175A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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