CCK-B Receptor antibody

Principal name

CCK-B Receptor antibody

Alternative names for CCK-B Receptor antibody

CCKB Receptor, Cholecystokinin type B receptor, CCK-BR, CCKBR, CCKRB, Cholecystokinin-2 receptor, CCK2-R, Gastrin/cholecystokinin type B receptor

SwissProt ID

P30552 (Canfa), P30553 (Rat), P32239 (Human), P56481 (Mouse), P79266 (Bovin)

Gene ID

887 (CCKBR), 12426 (Cckbr), 25706

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Hst (Hamster), Mky (Monkey), Prim (Primate), Rb (Rabbit), Bov (Bovine), Bt (Bat), Can (Canine), Eq (Equine)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CCK-B Receptor antibody

Cholecystokinin B Receptor (CCKBR) also known as the Gastrin Receptor and CCKR2, belongs to the 7-transmembrane domain, G-Protein Coupled Receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides. CCK and gastrin are related linear peptides that occur in different forms but share the last five C-termil amino acid residues. CCK regulates several nutritiol-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestil transit, while gastrin's main function is the stimulation of gastric acid secretion. Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+ mobilization. CCKBR was origilly identified in the brain (and hence its me, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa.

General readings

1. El-Kouhen K, Morisset J. Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells. Int J Endocrinol. 2009;2009:875167.
PMID: 20011057
2. Berna MJ, Seiz O, Nast JF, Benten D, Bläker M, Koch J, Lohse AW, Pace A. CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production.
J Biol Chem. 2010 Dec 10;285(50):38905-14. PMID: 20843811
3. El-Kouhen K, Morisset J. Control of somatostatin (SS) secretion by CCK-1 and CCK-2 receptors' occupation in RIN-14B cells, a rat pancreatic islet cell line. Pancreas. 2010 Mar;39(2):127-34. PMID: 19959964.
4. Quattrone A, Dewaele B, Wozniak A, Bauters M, Vanspauwen V, Floris G, Schöffski P, Chibon F, Coindre JM, Sciot R, Debiec-Rychter M. Promoting role of cholecystokinin 2 receptor (CCK2R) in gastrointestinal stromal tumours pathogenesis. J Pathol. 2012 Jul 11. doi: 10.1002/path.4071. PMID: 22786615

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CCK-B Receptor (251-266) antibody

Antibody staining (AP08587PU-N at 5 µg/ml) of  Formalin-Fixed Paraffin-Embedded Human Placenta. Goat IgG Aff - Purified Elephant, Hu E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CCK-B Receptor antibody

  Goat Polyclonal Antibody against CCKBR  
TA303029 (3µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen retrieval with Tris/EDTA buffer pH9, HRP-staining. Goat Aff - Purified Bov, Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CCK-B Receptor antibody

  Rabbit polyclonal anti-CCKBR antibody  
Western blot analysis of extracts from COS-7 cells, A549 cells and K562 cells, using CCKBR antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CCK-B Receptor antibody

  Anti-CCKBR Rabbit Polyclonal Antibody  
Gel: 8%SDS-PAGE,Lysate: 40 µg,,Primary antibody:CCKBR Antibody at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 40 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CCK-B Receptor antibody

  Rabbit Polyclonal Anti-Cholecystokinin B Receptor (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain membranes: 1, 2. Anti-Cholecystokinin B Receptor (extracellular) antibody, (1:200). 3, 4. Anti-Cholecystokinin B Receptor (extracellular), preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CCK-B Receptor (3rd Cytopl. Dom.) antibody

  Rabbit Polyclonal Anti-CCKBR Antibody (Cytoplasmic Domain)  
CCK-B Receptor Rabbit Aff - Purified Hu, Mky P
50 µg / €400.00
  OriGene Technologies, Inc.

CCK-B Receptor antibody

  Rabbit Polyclonal Anti-CCKBR Antibody (Extracellular Domain)  
Anti-CCKBR antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Bt, Can, Eq, Hst, Hu, Mky, Ms, Rb, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

CCK-B Receptor antibody

Western blot analysis of CCK-BR antibody (Cat.-No.: AP01421PU-N) in Hela whole cell lysate at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CCK-B Receptor (191-204) antibody

CCK-B Receptor Rabbit Serum Hu WB
0.1 ml / €380.00
  Acris Antibodies GmbH

CCK-B Receptor (191-204) antibody

CCK-B Receptor Rabbit Serum Hu WB
20 µl / €150.00
  Acris Antibodies GmbH

CCK-B Receptor (206-219) antibody

CCK-B Receptor Rabbit Serum Hu P, WB
0.1 ml / €380.00
  Acris Antibodies GmbH

CCK-B Receptor (206-219) antibody

CCK-B Receptor Rabbit Serum Hu P, WB
20 µl / €150.00
  Acris Antibodies GmbH

CCK-B Receptor antibody

Western blot analysis of extracts from A549/COS7/K562 cells, using CCKBR Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

CCK-B Receptor antibody

Western blot analysis of extracts from A549/COS7/K562 cells, using CCKBR Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

Lysates

Catalog No.    

CCKBR overexpression lysate

CCKBR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cckbr (GFP-tagged ORF) - Rat cholecystokinin B receptor (Cckbr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cckbr (GFP-tagged ORF) - Rat cholecystokinin B receptor (Cckbr), 200 uL, >10^7 TU/mL  
200 µl / €1,060.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cckbr (Myc-DDK-tagged ORF) - Rat cholecystokinin B receptor (Cckbr), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cckbr (Myc-DDK-tagged ORF) - Rat cholecystokinin B receptor (Cckbr), 200 uL, >10^7 TU/mL  
200 µl / €944.00
  OriGene Technologies, Inc.

17 Item(s)

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