CCR10 / GPR2 antibody

Principal name

CCR10 / GPR2 antibody

Alternative names for CCR10 / GPR2 antibody

C-C chemokine receptor type 10, C-C CKR-10, CC-CKR-10, CCR-10, G-protein coupled receptor 2

SwissProt ID

P46092 (Human), Q9JL21 (Mouse)

Gene ID

2826 (CCR10), 1238 (CCBP2), 12777 (Ccr10)

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Bear, Gorilla

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Flow Cytometry (F)

Background of CCR10 / GPR2 antibody

CCR10, C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. CCR10 is constitutively expressed in skin melanocytes, fibroblasts, and microvascular endothelial cells, and that it is upregulated by IL1B and TNF. Expression was also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in dendritic cells.By fluorescence in situ hybridization, the GPR2 gene is mapped to 17q21.1-q21.3. CCR10 is the receptor for CCL27. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, contact dermatitis, and psoriasis patients. CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients. Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes. CCR10 is predominantly expressed on CD4+CLA+ (cutaneous lymphocyte antigen), rather than CD8+, circulating T cells. RT-PCR, confocal microscopy, and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27.

General readings

This product has been used in:Wang W et al. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J Biol Chem 275:22313-23 (2000). PubMed PMID: 10781587
Zaballos A et al. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J Immunol 162:5671-5 (1999). PubMed PMID: 10229797
3. Murakami, T., et al. Immune evasion by murine melanoma mediated through CC chemokine receptor-10. J. Exp. Med. 198(9):1337-1347, 2003.
4. Luttichaux IV, et al. Human adult CD34() progenitor cells functionally express the chemokine receptors CCr1, CCR4, CCR7, CXCR5, and CCR10 but not CXCR4. Stem Cell Dev. 14(3):329-336, 2005.
5. Notohamiprodjo, M., et al. CCR10 is expressed in cutaneous T-cell lymphoma. Int. J. Cancer. 115(4): 641-647, 2005.
6. Hirata, T., et al. Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-assocaited chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus. J. Biol. Chem. 279(50): 51775-51782, 2004.

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CCR10 / GPR2 (C-term) antibody

Anti-CCR10 / GPR2 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Mky P
50 µg / €345.00
  OriGene Technologies, Inc.

CCR10 / GPR2 (2nd extracell. dom.) antibody

Anti-CCR10 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Hst, Hu, Mky, Ms, Por, Rb, Rt P
50 µg / €345.00
  OriGene Technologies, Inc.

CCR10 / GPR2 (N-term) antibody

Anti-CCR10 antibody IHC of human skin, capillaries. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bt, Hu, Mky, Por, Rb, Rt P
50 µg / €345.00
  OriGene Technologies, Inc.

CCR10 / GPR2 (350-362) antibody

Liver: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms F, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CCR10 / GPR2 antibody

Western blot analysis for CCR10. Using CCR10 polyclonal antibody ( Cat # PAB0165 ) at 2 µg/ml dilution against 10 ug of MCF-7 ( a human breast cancer cell line ) cell lysate. Rabbit Hu C, F, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CCR10 / GPR2 antibody

CCR10 / GPR2 Rabbit Hu, Ms WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

CCR10 / GPR2 antibody

CCR10 / GPR2 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

CCR10 / GPR2 antibody

Immunohistochemistry: CCR 10 Antibody [NB100-707] - Immunohistochemistry on paraffin sections of human spleen Goat Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

CCR10 / GPR2 antibody

Western Blot: CCR10 Antibody [NB100-56319] - Western blot analysis for CCR10 using NB100-56319 at 2 ug/ml dilution against 10 ug of MCF-7 (a human breast cancer cell line) cell lysate. Rabbit IgG Aff - Purified Hu WB
0.1 mg / €320.00
  Novus Biologicals Inc.

CCR10 / GPR2 antibody

Thymus Rabbit Aff - Purified Hu P
50 µl / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CCR10 / GPR2

CCR10 / GPR2 Human
2 µg / €450.00
  Abnova Taiwan Corp.

CCR10 / GPR2

CCR10 / GPR2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CCR10 / GPR2

CCR10 / GPR2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

13 Item(s)

per page
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