CCS / SOD4 antibody

Principal name

CCS / SOD4 antibody

Alternative names for CCS / SOD4 antibody

Superoxide Dismutase Copper Chaperone, SOD-4

SwissProt ID

O14618 (Human), Q6PWT7 (Pig), Q9JK72 (Rat), Q9WU84 (Mouse)

Gene ID

9973 (CCS), 12460 (Ccs), 84485

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of CCS / SOD4 antibody

Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Copper chaperone for SOD-1 (CCS) is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. CCS interacts with both wildtype and mutated forms of SOD-1 through CCS domains that are homologous in SOD-1. CCS exists as a homodimer that may form a heterodimer with SOD-1 during copper loading. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. The gene for CCS maps to human chromosome 11q13.

General readings

Romerius P., et al. (2010) Clin Cancer Res. 16(15):3843-50.
Seetharaman SV., et al. (2010) Biochemistry. 49(27):5714-25.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CCS / SOD4 antibody

  Rabbit polyclonal anti-CCS antibody  
Western blot analysis of extracts from Jurkat cells and 3T3 cells, using CCS antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CCS / SOD4 antibody

  Rabbit Polyclonal Anti-CCS Antibody  
WB Suggested Anti-CCS Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CCS / SOD4 antibody

  Rabbit Polyclonal Anti-CCS Antibody  
CCS / SOD4 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CCS / SOD4 antibody

Western blot (WB) analysis of CCS antibody (Cat.-No.: AP21158PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CCS / SOD4 antibody

Western blot analysis of extracts from NIH-3T3/Jurkat cells, using CCS Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

CCS / SOD4 antibody

Western blot analysis of extracts from NIH-3T3/Jurkat cells, using CCS Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CCS - human gene knockout kit via CRISPR

CCS - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CCS - human gene knockout kit via CRISPR

CCS - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCS - human gene knockout kit via CRISPR

CCS - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCS - human gene knockout kit via CRISPR

CCS - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccs - mouse gene knockout kit via CRISPR

Ccs - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ccs - mouse gene knockout kit via CRISPR

Ccs - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccs - mouse gene knockout kit via CRISPR

Ccs - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ccs - mouse gene knockout kit via CRISPR

Ccs - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CCS / SOD4 (1-274, His-tag)

CCS / SOD4 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH

CCS / SOD4 (1-274, His-tag)

CCS / SOD4 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

CCS overexpression lysate

CCS overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CCS (mGFP-tagged) - Human copper chaperone for superoxide dismutase (CCS), 200 uL, >10^7 TU/mL

Lenti ORF particles, CCS (mGFP-tagged) - Human copper chaperone for superoxide dismutase (CCS), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, CCS (Myc-DDK tagged) - Human copper chaperone for superoxide dismutase (CCS) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CCS (Myc-DDK tagged) - Human copper chaperone for superoxide dismutase (CCS) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ccs (GFP-tagged ORF) - Rat copper chaperone for superoxide dismutase (Ccs), 200 uL, >10^7 TU/mL

Lenti ORF particles, Ccs (GFP-tagged ORF) - Rat copper chaperone for superoxide dismutase (Ccs), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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