CCS / SOD4 antibody

Principal name

CCS / SOD4 antibody

Alternative names for CCS / SOD4 antibody

Superoxide Dismutase Copper Chaperone, SOD-4

SwissProt ID

O14618 (Human), Q6PWT7 (Pig), Q9JK72 (Rat), Q9WU84 (Mouse)

Gene ID

9973 (CCS), 12460 (Ccs), 84485

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Paraffin Sections (P)

Background of CCS / SOD4 antibody

Cu-Zn superoxide dismutase-1 (SOD-1) is a well characterized cytosolic scavenger of oxygen free radicals that requires copper and zinc binding to potentiate its enzymatic activity. Copper chaperone for SOD-1 (CCS) is essential for the incorporation of copper into SOD-1, and therefore is necessary for its enzymatic activity. CCS prevents copper ions from binding to intracellular copper scavengers and provides the SOD-1 enzyme with the necessary copper cofactor. CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. CCS interacts with both wildtype and mutated forms of SOD-1 through CCS domains that are homologous in SOD-1. CCS exists as a homodimer that may form a heterodimer with SOD-1 during copper loading. While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. The gene for CCS maps to human chromosome 11q13.

General readings

Romerius P., et al. (2010) Clin Cancer Res. 16(15):3843-50.
Seetharaman SV., et al. (2010) Biochemistry. 49(27):5714-25.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CCS / SOD4 antibody

  Rabbit Polyclonal Anti-CCS Antibody  
WB Suggested Anti-CCS Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Liver Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

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