CCT2 / TCP1 beta antibody

Principal name

CCT2 / TCP1 beta antibody

Alternative names for CCT2 / TCP1 beta antibody

99D8.1, CCT-beta, CCTB, TCP-1 beta, T-complex protein 1 subunit beta

SwissProt ID

P78371 (Human), P80314 (Mouse), P86245, Q3ZBH0 (Bovin), Q5XIM9 (Rat)

Gene ID

10576 (CCT2)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Frog, Ze (Zebrafish), Chimp (Chimpanzee), Eq (Equine), GP (Guinea Pig), Ye (Yeast)

Available hosts

Rat, Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), Immunoprecipitation (IP)

Background of CCT2 / TCP1 beta antibody

TCP1 beta is a subunit of a cytosolic hetero-oligomer chaperone (1,2) that is known to be involved in the folding of actin and tubulin. This protein is a member of the chaperonin family, which includes Escherichia coli GroEL, the mitochondrial heat-shock protein Hsp60, the plastid Rubisco-subunit-binding protein and the archaebacterial protein TF55. These chaperonins assist the folding of proteins upon ATP hydrolysis. Nine different subunits of TCP-1 containing chaperonin complexes from mammalian testis and seven different subunits of mouse F9 cells have been identified. The mouse TCP-1 subunits are between 531 and 545 residues in length. Their sequences are 2536% identical to one another, 2735% identical to that of TCP1 alpha and 3239% identical to that of the archaebacterial chaperonin, TF55. The genes for these subunits have been named Cctb, Cctg, Cctd, Ccte, Cctz and Ccth, which encode the CCTb, CCTg, CCTd, CCTe, CCTz, and CCTh subunits, respectively, of the `Chaperonin Containing TCP-1' (CCT). In bovine, CTT has also been referred to as `TRic', TCP-1 ring complex. All the CCT subunits contain motifs that are also shared by all other known chaperonins of prokaryotes and eukaryotic organelles, and that probably relate to their common ATPase function. It has been suggested that each CCT subunit has a specific, independent function, as they are highly diverged from each other but conserved from mammals to yeast. The expansion in the number of types of CCT subunit, compared with other chaperonins, has allowed CCT to carry out more complex functions that are required for the folding and assembly of highly evolved eukaryotic proteins.

General readings

General / background references:Hynes G et al. Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis. FEBS Lett 358:129-32 (1995). PubMed PMID: 7828721
Kubota H et al. Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin. Curr Biol 4:89-99 (1994). PubMed PMID: 7953530
Willison K et al. The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes. Cell 57:621-32 (1989). PubMed PMID: 2655925
Willison KR et al. Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1. Cell 44:727-38 (1986). PubMed PMID: 3753900

  1. Quick-Filters:
  2. Highly Validated (3)

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CCT2 / TCP1 beta antibody

Immunofluorescence analysis of 3T3-L1 cells using CCT2 Mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Mouse IgG1 5B5C4 Ascites Hu, Mky, Ms, Rt E, ICC/IF, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CCT2 / TCP1 beta (227-473) antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CCT2 / TCP1 beta antibody

Immunohistochemistry: TCP1-beta Antibody (EPR4084) [NBP1-40823] - Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TCP1 beta Rabbit IgG EPR4084 Hu, Ms, Rt F, ICC/IF, IP, P, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

CCT2 / TCP1 beta antibody

Sample (50 ug of whole cell lysate). A: Mouse brain. 7.5% SDS PAGE. TA308346 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CCT2 / TCP1 beta antibody

WB Suggested Anti-CCT2 Antibody; Titration: 1.0 ug/ml; Positive Control: MCF7 Whole Cell CCT2 is strongly supported by BioGPS gene expression data to be expressed in Human MCF7 cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CCT2 / TCP1 beta antibody

Immunohistochemical staining of normal (left) and cancerous (right) colon tissue using TCP1 beta Antibody Cat.-No. AM05385PU-N (Clone F39 P7 F11). Mouse IgG2a F39 P7 F11 Purified Frog, Hu, Ms, Rt P, WB
0.2 mg / €340.00
  Acris Antibodies GmbH

CCT2 / TCP1 beta antibody

Western blot analysis using CCT2 antibody Cat.-No AM06677SU-N against human CCT2 (AA: 87-290) recombinant protein (Expected MW is 47.9 kDa) Mouse IgG1 5B5F5 Ascites Hu E, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CCT2 / TCP1 beta antibody

AM20387PU-N CCT2 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen Rat IgG1 PK/8/4/4i/2f Aff - Purified Bov, Can, Hst, Mky, Ms, Por, Rb, Rt, Sh P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CCT2 / TCP1 beta antibody

Western blot analysis of HeLa whole cell lysate (Lane 1) and HeLa heat stressed whole cell
lysate (Lane 2) probed with Rat Anti Human CCT Beta antibody (SM2016P) followed by F(ab')2 Rabbit Anti Rat IgG:HRP (SP1021HRP). Rat IgG2b PK/8/4/4i/2F Aff - Purified Bov, Can, Chk, Hst, Hu, Mky, Ms, Por, Rb, Rt, Sh WB
0.1 mg / €640.00
  Acris Antibodies GmbH

CCT2 / TCP1 beta antibody

Immunofluorescence of monoclonal antibody to CCT2 on A-431 cell. [antibody concentration 10 ug/ml] Mouse IgG1 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CCT2 / TCP1 beta antibody

CCT2 / TCP1 beta Rat IgG2b PK/8/4/4i/2f Aff - Purified Bov, Can, Hu, Ms, Rb, Rt, Sh WB
50 µg / €360.00
  Novus Biologicals Inc.

CCT2 / TCP1 beta antibody

Western  Blot:  TCP1-beta Antibody [NBP1-33418] – Western blot analysis of TCP1-beta on Hep G2 (Lane A) and Raji (Lane B) lysates using NBP1-33418 at a dilution of 1:1000. 30ug whole cell lysate loaded on 7.5% SDS PAGE gel. Rabbit IgG Hu P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CCT2 / TCP1 beta antibody

Immunohistochemistry-Paraffin: TCP1-beta Antibody [NBP1-88146] - Immunohistochemical staining of human adrenal gland shows cytoplasmic positivity in cortical cells. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

CCT2 / TCP1 beta antibody

Immunohistochemistry-Paraffin: TCP1-beta Antibody [NBP1-88147] - Immunohistochemical staining of human stomach shows cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CCT2 / TCP1 beta

CCT2 / TCP1 beta Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CCT2 / TCP1 beta

CCT2 / TCP1 beta Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CCT2 / TCP1 beta

CCT2 / TCP1 beta Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

CCT2 / TCP1 beta

CCT2 / TCP1 beta Human
0.1 mg / €330.00
  Abnova Taiwan Corp.

18 Item(s)

per page
  • LinkedIn