CD104 / Integrin beta-4 antibody

Principal name

CD104 / Integrin beta-4 antibody

Alternative names for CD104 / Integrin beta-4 antibody

ITGB4, GP150

SwissProt ID

A2A863 (Mouse), A2A864, P16144 (Human), Q64632 (Rat)

Gene ID

3691 (ITGB4), 192897

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rat, Mouse, Rabbit, Chicken

Available applications

Frozen Sections (C), Flow Cytometry (F), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN)

Background of CD104 / Integrin beta-4 antibody

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins.
Integrin b4 (CD104)  associates with integrin α6 (CD49f) forming the α6/β4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the proliferative basal layer epithelial cells in skin), endothelial cells, Schwann cells, certain tumor cells and a subset of pre-T cells. CD49f/CD104 is an adhesion receptor for laminins (especially laminin 5) and keratin filaments and is involved in the regulation of hemidesmosome formation and of cell proliferation and activation.
CD104 is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

General readings

1. Kennel, S.J. et al. (1990) Second generation monoclonal antibodies to the human integrin alpah6 beta4.
Hybridoma 9: 243-254.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD104 / Integrin beta-4 (1619-1822) antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using ITGB4 mouse mAb with DAB staining. Mouse IgG1 10B10D5 Ascites Hu E, F, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Western blot analysis of extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins), using ITGB4 (Ab-1510) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD104 / Integrin beta-4 antibody

Staining of the A549 cell line with 0.5 ug of Rat IgG2b K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD104 (Integrin beta 4) Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE .  Total viable cells were used for analysis. Rat 439-9B Purified Hu F, IP, P, WB
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD104 / Integrin beta-4 antibody

Western blot analysis of Integrin ß4 expression in HepG2 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD104 / Integrin beta-4 antibody

Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Rat IgG2b 439-9B Purified Hu C, F, P, WB
0.1 mg / €470.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Immunohistochemistry on frozen section of human skin showing strong staining of basal membrane (e.g. cells of sebaceous gland and sweat gland and cells forming the hair in the hair shaft) and connective tissue; no staining of muscle cells. Mouse IgG2a 58XB4 Purified Hu C, E, F, ICC/IF, IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

CD104 / Integrin beta-4 Mouse IgG2a UM-A9 Purified Hu C, F, ICC/IF, IP, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

CD104 / Integrin beta-4 Mouse IgG2a UM-A9 Purified Hu C, F, ICC/IF, IP, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

CD104 / Integrin beta-4 Mouse IgG2a UM-A9 Purified Hu C, F, ICC/IF, IP, WB
20 µg / €160.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Immunohistochemistry analyzes of Integrin β4 antibody (Cat.-No.: AP20337PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 pTyr1510 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using ITGB4 (Phospho-Tyr1510) antibody AP55727PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 pTyr1510 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using ITGB4 (Phospho-Tyr1510) antibody AP55727PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €270.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

CD104 / Integrin beta-4 Mouse IgG1 450-9D Azide Free Hu C, F, IP, WB
1 mg / €810.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

CD104 / Integrin beta-4 Mouse IgG1 450-9D FITC Hu F
0.1 mg / €390.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

CD104 / Integrin beta-4 Mouse IgG1 450-9D FITC Hu F
25 µg / €190.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Cryostat section of human tonsil stained with anti-CD104 antibody (SM1205P/PT). Mouse IgG1 450-9D Purified Hu C, F, IP, WB
0.2 mg / €430.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Cryostat section of human tonsil stained with anti-CD104 antibody (SM1205P/PT). Mouse IgG1 450-9D Purified Hu C, F, IP, WB
25 µg / €180.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Staining of mouse thymocytes with RAT ANTI MOUSE CD104:FITC (SM2255F) Rat IgG2a 346-11A FITC Ms F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Staining of mouse thymocytes with RAT ANTI MOUSE CD104 (SM2255P) Rat IgG2a 346-11A Purified Ms C, F, IP, WB
0.25 mg / €390.00
  Acris Antibodies GmbH

CD104 / Integrin beta-4 antibody

Staining of mouse thymocytes with RAT ANTI MOUSE CD104 (SM2255P) Rat IgG2a 346-11A Purified Ms C, F, IP, WB
25 µg / €170.00
  Acris Antibodies GmbH

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