CD107b / LAMP2 antibody

Principal name

CD107b / LAMP2 antibody

Alternative names for CD107b / LAMP2 antibody

LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2

SwissProt ID

P13473 (Human), P17046 (Rat), P17047 (Mouse), P49130 (Crigr), Q90617 (Chick)

Gene ID

16784 (Lamp2), 3920 (LAMP2)

Available reactivities

Hu (Human), Ms (Mouse), Rb (Rabbit), Can (Canine), Mink, Rt (Rat)

Available hosts

Rabbit, Rat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Immunoelectron Microscopy (EM)

Background of CD107b / LAMP2 antibody

Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3).
LAMP2 has also been detected at the plasma membrane of cells, as well as in cells that secrete lysosomal hydrolases. A study in the developmental expresses patterns of membrane LAMP2 transcripts indicate a possible involvement of this protein in cell-cell or cellextracellular matrix interaction, and appear to reflect tissue and cell type specific roles of lysosomes during
morphogenesis (4).
Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxylterminal tyrosine based motif (YXXI) (5). This stimulation has also been shown to have an associated release of histamine, leukotriene C 9$) and prostaglandin D 9@), which shows that LAMP1 and LAMP2 are activation markers for normal mast cells (5). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (6).
LAMP2 has also been shown to be critical for autophagy, in conversion of early autophagic vacuoles to vacuoles which rapidly degrade their content (7).

General readings

1. Chen, J.W., W. Pan, M.P. d'Souza and J.T. August. 1985. Arch. Biochem. Biophys. 239:574-586.
2. Chen, J.W., G.L. Chen, M.P. d'Souza T.L. Murphy, and J.T. August. 1986. Biochem. Soc. Symp. 51:97-112.
3. Fukuda, M. 1991. J. Biol. Chem. 266:21327-21330.
4. Kannan, K., R.M. Stewart, W. Buunds, S.R. Carlsson, M. Fukuda, K.W. Betzing, and R.F. Hollcombe. 1996. Cell. Immunol.
171:10-19.
5. Furuta, K., X.L. Yang, J.S. Chen, S.R. Hamilton, and T.J. August. 1999. Arch. Biochem. Biophys. 365:75-82.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD107b / LAMP2 antibody

CD107b / LAMP2 Mouse IgG1 AC17 FITC Can, Hu, Mink EM, F
0.1 mg / €630.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Mouse IgG1 AC17 Purified Can, Hu, Mink EM, F, ICC/IF, IP, WB
0.25 mg / €550.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

Western Blot: LAMP2 Antibody [TA336814] - Analysis of Lamp2 in HeLa whole cell extract. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

CD107b / LAMP2 (C-term) antibody

Western blot analysis of LAMP-2 in HepG2 cell lysate with LAMP-2 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD107b / LAMP2 antibody

Distribution of lysosomes in CEC was determined using Anti-LAMP2, shown with IF. Rat IgG1 GL2A7 Purified Ms, Rb ICC/IF, IP
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD107b / LAMP2 antibody

Western blot analysis of LAMP2 in lysate from Jurkat cells (Lane 1& 2), 3T3 cells (Lane 3) and rat kidney (Lane 4). Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD107b / LAMP2 antibody

Staining of thioglycolate-induced peritoneal exudate cells (PECs) with Anti-Mouse CD107b (Mac-3) FITC (left) and Anti-Mouse CD107b (Mac-3) PE (right).  Autofluorescence is shown via open histogram.  Cells in the large scatter population were used for analysis. Rat M3/84 Purified Ms F
50 µg / €120.00
  OriGene Technologies, Inc.

CD107b / LAMP2 antibody

Western Blot: LAMP2 Antibody (H4B4) [TA336932] - Analysis of LAMP2 expression in HeLa, Jurkat, U937, HepG2 whole cell lysates, human kidney, lung, liver and placenta tissue extracts. Mouse IgG1 H4B4 Purified Hu, Ms C, F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD107b / LAMP2 antibody

Distribution of lysosomes in CEC was determined using Anti-LAMP2, shown with IF. Rat IgG1 GL2A7 Purified Ms, Rb ICC/IF, IP
25 µg / €240.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Rat IgG2a ABL-93 APC Ms F
0.1 mg / €290.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Rat IgG2a ABL-93 FITC Ms F
0.5 mg / €360.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Rat IgG2a ABL-93 Purified Ms C, F, IP
0.5 mg / €320.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Mouse IgG1 H4B4 Biotin Hu F
100 Tests / €280.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Mouse IgG1 H4B4 FITC Hu F
100 Tests / €290.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

Western Blot analysis using CD107b / LAMP2 Antibody Cat.-No AM08170PU-N (Clone H4B4) at 2 µg/ml in 1 mg/ml lysate, HeLa 10 µg (Lane 1+2), Raw 20µg (Lane 3+4) lysate, blocking buffer (Blotto; 5% dry milk powder in TBST). R1253HRP anti-Mouse IgG (H+L)-HRP as secondary antibody. Mouse IgG1 H4B4 Purified Hu C, F, P, WB
0.1 mg / €190.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

CD107b / LAMP2 Mouse IgG1 H4B4 PE Hu F
100 Tests / €320.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

AP07767PU-N LAMP2 antibody staining of Formalin-Fixed Paraffin-Embedded Human Placenta at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD107b / LAMP2 Control Peptide

CD107b / LAMP2
50 µg / €160.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

Staining of permeabilised mouse peritoneal macrophages with Rat Anti Mouse CD107b -FITC conjugated (SM2211F/FT). Rat IgG1 M3/84 FITC Ms F
0.1 mg / €280.00
  Acris Antibodies GmbH

CD107b / LAMP2 antibody

Staining of mouse peritoneal macrophages with RAT ANTI MOUSE CD107b (SM2211P)following
permeabilsation with Leucoperm Rat IgG1 M3/84 Purified Ms C, F, IP, P, WB
0.25 mg / €390.00
  Acris Antibodies GmbH

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