CD110 antibody

Principal name

CD110 antibody

Alternative names for CD110 antibody

MPL, TPOR, TPO-R, Myeloproliferative leukemia protein

SwissProt ID

P40238 (Human), Q08351 (Mouse)

Gene ID

4352 (MPL)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CD110 antibody

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

General readings

Cancer Res. 2009 Apr 15;69(8):3681-8.
J Biol Chem. 2009 May 1;284(18):11781-91.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD110 antibody

Western blot analysis using MPL antibody Cat.-No AM06740PU-N against human MPL (AA: 307-362) recombinant protein (Expected MW is 32.2 kDa). Mouse IgG2b 1H2 Purified Hu E, F, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

CD110 antibody

Western Blot analysis of MPL expression in transfected 293T cell line (H00004352-T01) by MPL MaxPab polyclonal antibody.

Lane1:MPL transfected lysate(69.85 KDa).
Lane2:Non-transfected lysate. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD110 antibody

CD110 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

CD110 antibody

Western Blot analysis of MPL expression in transfected 293T cell line (H00004352-T01) by MPL MaxPab polyclonal antibody.

Lane 1: MPL transfected lysate(71.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD110 antibody

Western Blot: TPOR Antibody (EPR4194) [NBP1-95467] (A) HepG2, (B) A431, and (C) human marrow lysates using anti-TPOR. Rabbit EPR4194 Purified Hu, Ms, Rt F, WB
0.1 ml / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD110

CD110 Human
10 µg / €540.00
  Abnova Taiwan Corp.

CD110

CD110 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CD110

CD110 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

MPL (Human) IP-WB Antibody Pair

MPL (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MPL 293T Cell Transient Overexpression Lysate(Denatured)

MPL 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

10 Item(s)

per page
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