CD110 antibody

Principal name

CD110 antibody

Alternative names for CD110 antibody

MPL, TPOR, TPO-R, Myeloproliferative leukemia protein

SwissProt ID

P40238 (Human), Q08351 (Mouse)

Gene ID

4352 (MPL)

Available reactivities

Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of CD110 antibody

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

General readings

Cancer Res. 2009 Apr 15;69(8):3681-8.
J Biol Chem. 2009 May 1;284(18):11781-91.

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD110 antibody

Western blot analysis using MPL antibody Cat.-No AM06740PU-N against human MPL (AA: 307-362) recombinant protein (Expected MW is 32.2 kDa). Mouse IgG2b 1H2 Purified Hu E, F, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MPL - human gene knockout kit via CRISPR

MPL - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MPL - human gene knockout kit via CRISPR

MPL - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MPL - human gene knockout kit via CRISPR

MPL - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MPL - human gene knockout kit via CRISPR

MPL - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MPL (mGFP-tagged)-Human myeloproliferative leukemia virus oncogene (MPL), 200 uL, >10^7 TU/mL

Lenti ORF particles, MPL (mGFP-tagged)-Human myeloproliferative leukemia virus oncogene (MPL), 200 uL, >10^7 TU/mL  
200 µl / €1,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, MPL (Myc-DDK-tagged)-Human myeloproliferative leukemia virus oncogene (MPL), 200 uL, >10^7 TU/mL

Lenti ORF particles, MPL (Myc-DDK-tagged)-Human myeloproliferative leukemia virus oncogene (MPL), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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