CD111 / Nectin 1 antibody

Principal name

CD111 / Nectin 1 antibody

Alternative names for CD111 / Nectin 1 antibody

Nectin-1, PVRL1, HVEC, PRR1, Poliovirus receptor-related protein 1, Herpes virus entry mediator C, Herpesvirus Ig-like receptor

SwissProt ID

Q15223 (Human), Q9GL76 (Pig), Q9JKF6 (Mouse)

Gene ID

5818 (PVRL1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F)

Background of CD111 / Nectin 1 antibody

Nectins, which were origilly identified as virus receptors, are members of the cell-cell adhesion molecule (CAM) family. They are Ca2+-independent immunoglobulin-like CAMs. The nectin family comprises four members, nectin-1, nectin-2, nectin-3 and nectin-4, which are encoded by the PVRL1, PVRL2, PVRL3 and PVRL4 genes, respectively. In the central nervous system, these cell adhesion molecules aggregate in formations, termed puncta adherentia junctions, which are mechanical adhesive sites that connect pre- and postsyptic membranes. All nectins contain an extracellular region with three immunoglobulin-like loops (one V type and two C2 types), a single membrane-spanning region and a cytoplasmic tail. Nectins directly bind afadin, an F-actin-binding protein, through their cytoplasmic tails. Nectin-1 is expressed at cell-cell junctions in human and mouse epidermis. In mice lacking the gene encoding nectin-1 (Pvrl1-/- mice), the expression of loricrin, a differentiation marker and a major component of cornified cell envelopes in the epidermis, is downregulated and newborn pups have a shiny and slightly reddish skin. Mutations in human PVRL1 are implicated in cleft lip or palate-ectodermal dysplasia syndromes, which includes Zlotogora–Ogur syndrome and Margarita Island ectodermal dysplasia. Both of these are autosomal recessive disorders that are clinically characterized by unusual facial appearance, dental anomalies, hypotrichosis, palmoplantar hyperkeratosis and onychodysplasia, syndactyly, cleft lip or palate, and in some cases, mental retardation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD111 / Nectin 1 antibody

  PVRL1 mouse monoclonal antibody, clone OTI6F8 (formerly 6F8)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-PVRL1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503521) Mouse IgG1 OTI6F8 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD111 / Nectin 1 antibody

  PVRL1 mouse monoclonal antibody, clone OTI1B6 (formerly 1B6)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-PVRL1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503469) Mouse IgG2a OTI1B6 Purified Hu ICC/IF, P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

TrueMAB

2 Item(s)

per page
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