CD117 / c-kit antibody

Principal name

CD117 / c-kit antibody

Alternative names for CD117 / c-kit antibody

SCFR, KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase

SwissProt ID

O97799 (Canfa), P05532 (Mouse), P10721 (Human), P43481 (Bovin), Q08156 (Chick), Q2HWD6 (Pig)

Gene ID

16590 (Kit), 3815 (KIT), 378783

Available reactivities

Ms (Mouse), Can (Canine), Hu (Human), Bov (Bovine), Mky (Monkey), Rt (Rat), Chk (Chicken), Prim (Primate), Por (Porcine), Bt (Bat), Eq (Equine), Fe (Feline), Gt (Goat), Op (Opossum), Rb (Rabbit), L (Lizard), Bear

Available hosts

Rat, Rabbit, Mouse, Goat

Available applications

Flow Cytometry (F), Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Functional assay (FN), Luminex (LMNX)

Background of CD117 / c-kit antibody

C-Kit is the receptor tyrosine kinase for stem cell factor (SCF) and is a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors . It plays critical controlling roles in a number of cell types such as hematopoietic stem cells, mast cells, melanocytes and germ cells . Upon binding with its ligand, c-Kit receptors are induced undergoing dimerization/ oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCgamma, p85 subunit of PI3 kinase, SHP2 and CrkL, which links c-Kit directly to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders , while mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors . Tyrosine 719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo.

General readings

Cruz A. C. et al., J. Biol. Chem., 2004; 279(7): 5612 - 5620

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD117 / c-kit antibody

Human Gastrointestinal Stromal Tumor stained with anti-CD117_c-kit antibody. Rabbit IgG SP26 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD117 / c-kit antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-KIT rabbit polyclonal antibody. (TA590744) Rabbit IgG Purified Hu E, P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CD117 / c-kit antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-KIT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801036) Mouse IgG2a OTI2E3 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

CD117 / c-kit antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-KIT mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA801037) Mouse IgG1 OTI1E2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD117 / c-kit antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-KIT mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808721)(1:150) Mouse IgG2b OTI1B6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD117 / c-kit antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-KIT mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808739)(1:150) Mouse IgG2b OTI2B12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD117 / c-kit antibody

Immunohistochemical analysis of paraffin-embedded gastrointestinal stromal tumor using KIT mouse mAb with DAB staining. Mouse IgG1 1C5 Ascites Hu E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CD117 / c-kit (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human gastrointestinal tissue (4 μm) stained with anti-CD117 antibody (DB 062) shows strong immunostaining of neoplastic cell in large bowel stromal tumor. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R21-V Aff - Purified Hu P
0.1 ml / €270.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD117 / c-kit (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human gastrointestinal tissue (4 µm) stained with anti-CD117  antibody (DB 062) shows strong immunostaining of neoplastic cell in large bowel stromal tumor.  Kindly performed and provided by Katarina Poliakova, MD and .ubomir Straka, MD, PhD. from Clinical Pathology Pre.ov, Ltd., Pre.ov, Slovak republic. Rabbit IgG R21-V Aff - Purified Hu P
0.2 ml / €360.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD117 / c-kit (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human gastrointestinal tissue (4 μm) stained with anti-CD117 antibody (DB 062) shows strong immunostaining of neoplastic cell in large bowel stromal tumor. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R21-V Aff - Purified Hu P
0.5 ml / €450.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD117 / c-kit (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human gastrointestinal tissue (4 μm) stained with anti-CD117 antibody (DB 062) shows strong immunostaining of neoplastic cell in large bowel stromal tumor. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG R21-V Aff - Purified Hu P
1 ml / €690.00
  DB Biotech, spol. s r.o.

Sample sizes available

CD117 / c-kit antibody

Formalin-Fixed, Paraffin-Embedded Human gastro intestinal stromal tumor (GIST) stained with CD117 / C-Kit Antibody Cat.-No AM32824PU (Clone C117/370). Mouse IgG1 C117/370 Purified Hu P
0.2 mg / €390.00
  Acris Antibodies GmbH

CD117 / c-kit antibody

Formalin-Fixed, Paraffin-Embedded Human gastro intestinal stromal tumor (GIST) stained with CD117 / C-Kit Antibody Cat.-No AM32824PU (Clone C117/370). Mouse IgG1 C117/370 Purified Hu P
0.1 mg / €320.00
  Acris Antibodies GmbH

CD117 / c-kit antibody

Formalin-Fixed, Paraffin-Embedded Human gastro intestinal stromal tumor (GIST) stained with CD117 / C-Kit Antibody Cat.-No AM32824PU (Clone C117/370). Mouse IgG1 C117/370 Purified Hu E, P
20 µg / €160.00
  Acris Antibodies GmbH

CD117 / c-kit antibody

Human gastrointestinal stromal tumor stained with CD117/c-kit antibody (Cat# AP15416PU) Rabbit Purified Can, Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

CD117 / c-kit antibody

Human gastrointestinal stromal tumor stained with CD117/c-kit antibody (Cat# AP15416PU) Rabbit Purified Can, Hu P
1 ml / €490.00
  Acris Antibodies GmbH

CD117 / c-kit antibody

Human gastrointestinal stromal tumor stained with CD117/c-kit antibody (Cat# AP15416PU) Rabbit Purified Can, Hu P
0.1 ml / €200.00
  Acris Antibodies GmbH

CD117 / c-kit antibody

Anti-KIT (1ug/ml) staining of Human Hippocampus lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD117 / c-kit antibody

Staining of C57BL/6 bone marrow cells with Anti-Human/Mouse CD45R (B220) FITC and 0.06 ug of Rat IgG2b kappa Isotype Control PE (left) or 0.125 ug of Anti-Mouse CD117 (c-Kit) PE (right).  Total viable cells were used for analysis. Rat 2B8 Purified Ms, Por F
0.1 mg / €150.00
  OriGene Technologies, Inc.

CD117 / c-kit antibody

CD117 / c-kit Rat ACK2 Purified Ms F, IP, P, WB
0.1 mg / €150.00
  OriGene Technologies, Inc.

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