CD11a / ITGAL antibody

Principal name

CD11a / ITGAL antibody

Alternative names for CD11a / ITGAL antibody

Integrin alpha-L, LFA1, LFA-1, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, CD11 antigen-like family member A

SwissProt ID

B5AZS0 (Horse), F1P8D8, G1T7A0, P20701 (Human), P24063 (Mouse), P61625 (Bovin), Q004B3 (Sheep), Q3T1L6 (Rat)

Gene ID

3683 (ITGAL), 308995 (Itgal), 281874, 16408

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Eq (Equine), Bov (Bovine), Por (Porcine), Sh (Sheep), Can (Canine)

Available hosts

Mouse, Rat, Goat, Rabbit

Available applications

Frozen Sections (C), Functional assay (FN), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Selected product citations ‐ of SM3100AS

1. Peckys, DB;Alansary, D;Niemeyer, BA;de Jonge, N;2016Visualizing Quantum Dot Labeled ORAI1 Proteins in Intact Cells Via Correlative Light and Electron Microscopy. Microsc. Microanal. 2016, 1-11. PubMed PMID:  27515473.

Background of CD11a / ITGAL antibody

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. 
LFA-1 is part of the family of leukocyte integrins that are recognised by their common β-chains (CD18). LFA-1 also has a distinct α-chain (CD11a). 
LFA-1 is expressed on lymphocytes, monocytes and granulocytes; it has been shown that LFA-1 contributes to the adhesion reaction of these cells. Blocking experiments with anti-LFA monoclonal antibodies demonstrated that LFA-1 inhibits the adhesion step effector and target cells in cytotoxic T lymphocyte, natural killer and lectin dependent cytotoxicity. 
LFA-1 is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first to bind T-cells to antigen-presenting cells and initially binds weakly. A signal from the T-cell receptor and/or the cytokine receptor changes the conformation and prolongs the cell contact, allowing the T-cell to proliferate.

General readings

1. Hogarth, P. Mark, Eva M. Eicher, and Ian F.C. McKenzie. 1986. Mapping of the Murine Ly 15 (LFA-1) Locus to Chromosome 7. Immunogenetics.
2. Hogarth, P. Mark, Ian D. Walker, Ian F.C. McKenzie, and Timothy A. Springer. 1985. The Ly-15 alloantigenic system: A Genetically Determined Polymorphism of the Murine Lymphocyte Function - Associated Antigen -1 Molecule. Proc. Natl. Acad. Sci. USA. 82: 526-530.
3 Potter, Terry A., P. Mark Hogarth, and Ian F.C. Mckenzie. 1981. Ly 15; A New Murine Lymphocyte Alloantigenic Locus. Transplantation. 31 (5): 339-342.
4. Marchalonis, John J. ed. The Lymphocyte Structure and Function. 1988. Marcel Dekker, Inc. Nw York. p. 250 - 253.

  1. Quick-Filters:
  2. Cited (2)

Items 1 to 20 of 79 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD11a / ITGAL antibody

CD11a / ITGAL Mouse IgG1 MEM-83 Azide Free Hu F, FN, IP
0.1 mg / €210.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

CD11a / ITGAL Mouse IgG1 MEM-83 Purified Hu F, FN, IP
0.1 mg / €210.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

  Goat Anti-CD11A / integrin alpha L Antibody  
TA305639 (0.5ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD11a / ITGAL antibody

  Mouse Anti-Human CD11a Purified (100 ug)  
Staining of normal human peripheral blood cells with Anti-Human CD11a FITC. Mouse HI111 Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD11a / ITGAL antibody

  Rat Anti-Mouse CD11a Purified (50 ug)  
Staining of mouse splenocytes with Anti-Mouse CD11a FITC (left) and PE (right).  Appropriate isotype controls were used  (open histogram). Total viable cells were used for analysis. Rat M17/4 Purified Ms F, IP, P
50 µg / €120.00
  OriGene Technologies, Inc.

CD11a / ITGAL antibody

  Anti-ITGAL Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human esophagus and liver cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus and liver cancer tissue using ITGAL antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD11a / ITGAL antibody

  Rabbit anti-ITGAL Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using ITGAL antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD11a / ITGAL (+ CD18) antibody

Staining of equine peripheral blood lymphocytes with CD11a / ITGAL antibody clone CVS9 Cat.-No. AM01043FC-N. Mouse IgG1 CVS9 FITC Eq F
0.1 mg / €450.00
  Acris Antibodies GmbH

CD11a / ITGAL (+ CD18) antibody

Staining of equine peripheral blood lymphocytes with mouse anti horse CD11a/ITGAL antibody clone CVS9 Cat.-No. AM1043PU-S, followed by secondary FITC conjugated antibody. Mouse IgG1 CVS9 Purified Eq C, F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD11a / ITGAL (+ CD18) antibody

CD11a / ITGAL Mouse IgG1 CVS9 PE Eq F
100 Tests / €510.00
  Acris Antibodies GmbH

CD11a / ITGAL (+ CD18) antibody

CD11a / ITGAL Mouse IgG1 CVS9 Supernatant Eq C, ICC/IF
2 ml / €440.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

CD11a / ITGAL Mouse IgG2a OFYS Biotin Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

CD11a / ITGAL Mouse IgG2a OFYS FITC Hu F
100 Tests / €270.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

CD11a / ITGAL Mouse IgG2a OFYS Purified Hu F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

Figure 1. Peripheral Blood Lymphocytes stained with PE labelled anti-CD11a antibody (AM05207RP-N). Mouse IgG2a OFYS PE Hu F
100 Tests / €300.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

CD11a / ITGAL Mouse IgG2b BL1H8 FITC Bov, Por, Sh F
0.1 mg / €530.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

Surface staining of mouse splenocytes using anti-CD11a monoclonal antibody (clone M17/4). Rat IgG2a M17/4 FITC Ms F
0.1 mg / €230.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

Surface staining of mouse splenocytes using anti-CD11a monoclonal antibody (clone M17/4). Rat IgG2a M17/4 Low Endotoxin Ms C, F, FN, IP
0.1 mg / €200.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

Surface staining of mouse splenocytes using anti-CD11a monoclonal antibody (clone M17/4). Rat IgG2a M17/4 Aff - Purified Ms C, F, FN, IP
0.1 mg / €160.00
  Acris Antibodies GmbH

CD11a / ITGAL antibody

histogram of Jurkat cells stained with 10mg/ml mouse anti-human CD11α monoclonal antibody.  Black line histogram represents Jurkat cells stained with isotype control, mouse anti-TB 38Kd antigen monoclonal antibody (Clone B12F8). Mouse IgG1 A11 Aff - Purified Hu C, E, F, P
0.5 mg / €420.00
  Acris Antibodies GmbH

Items 1 to 20 of 79 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
  • LinkedIn