CD11c antibody

Principal name

CD11c antibody

Alternative names for CD11c antibody

ITGAX, Integrin alpha-X, Leu M5, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150 95 alpha chain, Leukocyte adhesion receptor p150 95

SwissProt ID

E2RTG3, P20702 (Human), Q9QXH4 (Mouse)

Gene ID

3687 (ITGAX), 16411 (Itgax)

Available reactivities

Hu (Human), Mky (Monkey), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Hamster, Chicken, Rat

Available applications

Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Functional assay (FN), ELISA (detection) (E(detection))

Background of CD11c antibody

Leukocyte surface antigen p150,95 (ITAX) shares a beta subunit with 2 other members of the leukocyte adhesion molecule family, Mac-1 and LFA-1, but has a unique alpha chain. The extracellular domain contains three tandem homologous repeats of approximately 60 amino acids with putative divalent cation-binding sites, and four weaker repeats which lack such binding sites. The ITAX alpha subunit is homologous to the alpha subunits of receptors which recognize the RGD sequence in extracellular matrix components, as has previously been shown for the beta subunits, supporting the concept that receptors involved in both cell-cell and cell-matrix interactions belong to a single gene superfamily termed the integrins. Distinctive features of the ITAX alpha subunit include an insertion of 126 residues N-terminal to the putative metal binding region and a deletion of the region in which the matrix receptors are proteolytically cleaved during processing (1). The alpha subunit of the leukocyte integrin p150,95 (CD11c) is a transmembrane polypeptide of 1144 residues whose long extracellular region contains three putative divalent cation binding repeats and a 200- amino acid inserted or "I" domain.

General readings

General / background references:Arnaout MA Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol Rev 114:145-80 (1990). PubMed PMID: 1973407
Patarroyo M et al. Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology. Immunol Rev 114:67-108 (1990). PubMed PMID: 1973408
Kishimoto TK et al. The leukocyte integrins. Adv Immunol 46:149-82 (1989). PubMed PMID: 2551146
Hogg N et al. The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. Eur J Immunol 16:240-8 (1986). PubMed PMID: 3456894

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD11c antibody

CD11c Hamster IgG N418 Purified Ms C, F, ICC/IF, IP
0.25 mg / €390.00
  Acris Antibodies GmbH

CD11c antibody

Flow cytometric analysis of Mouse CD11c expression on Mouse splenocytes. The staining intensity of AM26635FC-N is shown in the horizontal axis with Mouse I-A b staining on the vertical axis. Rat IgG2a 223H7 FITC Ms F
50 µg / €300.00
  Acris Antibodies GmbH

CD11c antibody

Sample(30 ug whole cell lysate). A:H1299. B:Hep G2 . 7.5% SDS PAGE. TA308537 diluted at 1:1000 Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD11c antibody

Staining of normal human peripheral blood cells with Anti-Human CD11c FITC (left) and PE (right).  Appropriate isotype controls were used (open histogram).  Cells in the monocyte population were used for analysis. Mouse 3.9 Purified Hu F, P
25 µg / €120.00
  OriGene Technologies, Inc.

CD11c antibody

Staining of mouse splenocytes with Anti-Mouse CD11c FITC (left) and PE (right), and Anti-Human/Mouse CD45R (B220) APC.  Total viable cells were used for analysis. Hamster N418 Purified Ms F
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD11c antibody

Predicted cell location: Cytoplasm. Positive control: Human gastric cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using ITGAX antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD11c antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and ovarian cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human liver and ovarian cancer tissue using ITGAX antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD11c (C-term) antibody

Western blot analysis of ITGAX Antibody (C-term) (Cat. #TA324886) in MDA-MB231 cell line lysates (35ug/lane). ITGAX (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

CD11c antibody

Immunohistochemistry staining of Paraffin Hairy cell leukemia, bone marrow tissue by CD11c antibody (dilution: 1:20 - 1:80; visualization of staining: Cytoplasmic) Mouse IgG2a 5D11 Purified Hu P
1 ml / €560.00
  OriGene Technologies, Inc.

CD11c antibody

Anti-CD11c antibody IHC of human colon, neutrophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

CD11c antibody

Anti-CD11c antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10-20 ug/ml. Rabbit Aff - Purified Hu, Mky P
50 µg / €379.00
  OriGene Technologies, Inc.

CD11c antibody

CD11c Mouse IgG1 3.9 Biotin Hu C, F
0.2 mg / €470.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Mouse IgG1 CA11.6A1 Supernatant Can C, F, IP
2 ml / €450.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 Biotin Ms F
0.1 mg / €250.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 Biotin Ms F
25 µg / €180.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 FITC Ms F
0.5 mg / €560.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 FITC Ms F
0.1 mg / €270.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 FITC Ms F
25 µg / €190.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 Purified Ms C, F, ICC/IF, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

CD11c antibody

CD11c Hamster IgG N418 Purified Ms C, F, IP
25 µg / €170.00
  Acris Antibodies GmbH

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