CD121a / IL1R1 antibody

Principal name

CD121a / IL1R1 antibody

Alternative names for CD121a / IL1R1 antibody

IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I

SwissProt ID

P13504 (Mouse), P14778 (Human), Q02955 (Rat)

Gene ID

16177 (Il1r1), 3554 (IL1R1)

Available reactivities

Ms (Mouse), Hu (Human), Prim (Primate), Mky (Monkey), Rt (Rat)

Available hosts

Hamster, Rat, Goat, Mouse, Rabbit, Sheep

Available applications

Immunoprecipitation (IP), Flow Cytometry (F), Functional assay (FN), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Radioimmunoassay (R), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of CD121a / IL1R1 antibody

IL1 binds antigen CD121a, which is a transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. CD121a binds the mature forms of IL1 alpha, IL1 beta, and IL1 Ra proteins. High affinity binding and signalling by the type I IL1 receptor requires CD121a and the accessory protein, IL1 R AcP, which does not bind IL1 alone, but forms a dimer capable of binding IL1. Interleukin 1 (IL1), which has a role as a mediator in inflammation, consists of 2 separate but related proteins, IL1 alpha and IL1 beta. Cell surface receptors for the 2 forms of IL1 are identical. IL1R Type I contains a single membrane spanning segment, a large cytoplasmic region, and an extracellular, IL1 binding portion composed of 3 immunoglobulin like domains.

General readings

Beaulieu LM., et al. (2014) Arterioscler. Thromb. Vasc. Biol. 34:(3)552-564.Moos V., et al. (2000) Arthritis Rheum. 43(11):2417-22.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD121a / IL1R1 antibody

Predicted cell location: Cytoplasm. Positive control: Human breast and thyroid cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using IL1R1 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD121a / IL1R1 antibody

Predicted cell location: Cytoplasm. Positive control: Human lymphoma tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human lymphoma tissue using IL1R1 antibody at dilution 1/30, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD121a / IL1R1 antibody

CD121a / IL1R1 Mouse IgG2a BDI204 Purified Hu E, ICC/IF, R
0.2 mg / €590.00
  Acris Antibodies GmbH

CD121a / IL1R1 (Extracell. Dom.) antibody

AM20494PU-N IL1R1 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Placenta at 10 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG2b 40101 Purified Hu E, ICC/IF, P, R
50 µg / €470.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG1 D14e3 Purified Ms WB
0.1 mg / €410.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG1 D1f3 Purified Ms FN, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG2a Reg20 Purified Ms E, IP, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG1 REG21 Purified Ms E, FN, IP, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rabbit Serum Hu E, IP
1 ml / €1,150.00
  Acris Antibodies GmbH

CD121a / IL1R1 (Extracell. Dom.) antibody

CD121a / IL1R1 Hamster IgG JAMA-147 Purified Ms F, IP
0.25 mg / €400.00
  Acris Antibodies GmbH

CD121a / IL1R1 (Extracell. Dom.) antibody

CD121a / IL1R1 Hamster IgG JAMA-147 Purified Ms F, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

CD121a / IL1R1 (Extracell. Dom.) antibody

CD121a / IL1R1 Hamster IgG JAMA-147 Purified Ms F, IP
25 µg / €170.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

IL1R1 polyclonal antibody (A01), Lot # 050912JC01 Western Blot analysis of IL1R1 expression in HL-60 ( Cat # L014V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD121a / IL1R1 antibody

CD121a / IL1R1 Mouse IgG2a BDI204 Hu C, E, R
0.2 mg / €640.00
  Abnova Taiwan Corp.

CD121a / IL1R1 antibody

CD121a / IL1R1 Sheep Hu E
1 ml / €560.00
  Abnova Taiwan Corp.

CD121a / IL1R1 antibody

IL-1R staining of mouse thymus. Staining was done using HRP-DAB (brown) detection. Tissue was counterstained with haematoxylin (blue). Goat Aff - Purified Ms C, E, WB
0.1 mg / €450.00
  Neuromics Antibodies

CD121a / IL1R1 antibody

CD121a / IL1R1 Hamster IgG JAMA-147 Aff - Purified Ms F, IP
0.1 mg / €340.00
  Novus Biologicals Inc.

CD121a / IL1R1 antibody

Immunohistochemistry: IL1 Receptor I Antibody (RM0013-11B7) [NB110-85471] - IL1R-I immunohistochemistry staining of paraffin sections of mouse lung from LPS exposed animals. Rat IgG2 RM0013-11B7 Purified Ms P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

CD121a / IL1R1 antibody

Western Blot: IL1 Receptor I Antibody [NBP1-30929] - Western blot analysis of IL1 Receptor I Antibody on Raji, diluted at 1:1000 with 7.5% SDS PAGE gel. Rabbit IgG Hu Dot, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CD121a / IL1R1 antibody

Western Blot: IL1 Receptor I Antibody [NBP1-32929] - Western blot analysis of IL1 Receptor I on Molt-4 lysate using NBP1-32929 at a dilution of 1:5000. 30ug of whole cell lysate loaded on 7.5% SDS PAGE gel. Rabbit IgG Hu WB
0.1 mg / €420.00
  Novus Biologicals Inc.

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