CD121a / IL1R1 antibody

Principal name

CD121a / IL1R1 antibody

Alternative names for CD121a / IL1R1 antibody

IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I

SwissProt ID

P13504 (Mouse), P14778 (Human), Q02955 (Rat)

Gene ID

16177 (Il1r1), 3554 (IL1R1)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Goat, Rabbit, Hamster, Mouse, Sheep, Rat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Paraffin Sections (P), Functional assay (FN)

Background of CD121a / IL1R1 antibody

IL1 binds antigen CD121a, which is a transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. CD121a binds the mature forms of IL1 alpha, IL1 beta, and IL1 Ra proteins. High affinity binding and signalling by the type I IL1 receptor requires CD121a and the accessory protein, IL1 R AcP, which does not bind IL1 alone, but forms a dimer capable of binding IL1. Interleukin 1 (IL1), which has a role as a mediator in inflammation, consists of 2 separate but related proteins, IL1 alpha and IL1 beta. Cell surface receptors for the 2 forms of IL1 are identical. IL1R Type I contains a single membrane spanning segment, a large cytoplasmic region, and an extracellular, IL1 binding portion composed of 3 immunoglobulin like domains.

General readings

Beaulieu LM., et al. (2014) Arterioscler. Thromb. Vasc. Biol. 34:(3)552-564.Moos V., et al. (2000) Arthritis Rheum. 43(11):2417-22.

7 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD121a / IL1R1 antibody

CD121a / IL1R1 Mouse IgG2a BDI204 Purified Hu E, ICC/IF, R
0.2 mg / €630.00
  Acris Antibodies GmbH

CD121a / IL1R1 (Extracell. Dom.) antibody

AM20494PU-N IL1R1 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Placenta at 10 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG2b 40101 Purified Hu E, P, R
50 µg / €380.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG1 D14e3 Purified Ms WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG1 D1f3 Purified Ms FN, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG2a Reg20 Purified Ms E, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CD121a / IL1R1 antibody

CD121a / IL1R1 Rat IgG1 REG21 Purified Ms E, FN, IP, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

CD121a / IL1R1 (Extracell. Dom.) antibody

CD121a / IL1R1 Hamster IgG JAMA-147 Purified Ms F, IP
0.1 mg / €240.00
  Acris Antibodies GmbH

7 Item(s)

per page
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