CD121a / IL1R1 antibody

Principal name

CD121a / IL1R1 antibody

Alternative names for CD121a / IL1R1 antibody

IL1R, IL1RA, IL1RT1, Interleukin-1 receptor alpha, IL-1R-alpha, Interleukin-1 receptor type 1, Interleukin-1 receptor type I

SwissProt ID

P13504 (Mouse), P14778 (Human), Q02955 (Rat)

Gene ID

16177 (Il1r1), 3554 (IL1R1)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat)

Available hosts

Goat, Rabbit, Hamster, Mouse, Sheep, Rat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Paraffin Sections (P), Functional assay (FN)

Background of CD121a / IL1R1 antibody

IL1 binds antigen CD121a, which is a transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. CD121a binds the mature forms of IL1 alpha, IL1 beta, and IL1 Ra proteins. High affinity binding and signalling by the type I IL1 receptor requires CD121a and the accessory protein, IL1 R AcP, which does not bind IL1 alone, but forms a dimer capable of binding IL1. Interleukin 1 (IL1), which has a role as a mediator in inflammation, consists of 2 separate but related proteins, IL1 alpha and IL1 beta. Cell surface receptors for the 2 forms of IL1 are identical. IL1R Type I contains a single membrane spanning segment, a large cytoplasmic region, and an extracellular, IL1 binding portion composed of 3 immunoglobulin like domains.

General readings

Beaulieu LM., et al. (2014) Arterioscler. Thromb. Vasc. Biol. 34:(3)552-564.Moos V., et al. (2000) Arthritis Rheum. 43(11):2417-22.

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CRISPR

Catalog No. Species Donor Vector  

IL1R1 - human gene knockout kit via CRISPR

IL1R1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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