CD121b / IL1R2 antibody

Principal name

CD121b / IL1R2 antibody

Alternative names for CD121b / IL1R2 antibody

Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB, CD121 antigen-like family member B

SwissProt ID

P27930 (Human), P27931 (Mouse), P43303 (Rat)

Gene ID

7850 (IL1R2), 16178 (Il1r2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate)

Available hosts

Rabbit, Mouse, Rat, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), ELISA (detection) (E(detection)), Frozen Sections (C), Neutralisation (NEUT)

Background of CD121b / IL1R2 antibody

IL-1 receptor type II (IL1R-II) is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a "decoy" receptor.

General readings

Giroux, S., et al. Bone 47(5): 975-981 (2010)
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4): 361 (2010)
Bailey, S.D., et al. Diabetes Care 33(10): 2250-2253 (2010)
Chen, C., et al. Rheumatol. Int. (2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6): 608-613( 2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD121b / IL1R2 antibody

Western blot analysis of extracts of various cell lines, using IL1R2 antibody. Rabbit IgG Purified Hu, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD121b / IL1R2 antibody

IL1R2 MaxPab polyclonal antibody. Western Blot analysis of IL1R2 expression in human kidney. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD121b / IL1R2 antibody

Sample (30 ug of whole cell lysate). A: 293T. 10% SDS PAGE. TA308544 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD121b / IL1R2 antibody

WB using anti-IL-1RII antibody. This blot shows detection of an IL-1RII-GST fusion protein (~500 ng, lane 1, green, 800 nm channel).The primary antibody diluted to 1:1,000. Incubation was for 2 hrs at RT followed by washes and reaction with a 1:10,000 dilution of IRDye® 800 conjugated Gt-a-Rabbit IgG (H&L) for 45 min at room temperature. Molecular weight markers are shown for size comparison (lane M, red, 700 nm channel). Rabbit Serum Hu E, IP, WB
1 ml / €900.00
  OriGene Technologies, Inc.

CD121b / IL1R2 antibody

Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-200  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using IL1R2 antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD121b / IL1R2 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL1R2 (RC221860, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL1R2. Mouse IgG1 OTI3C6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD121b / IL1R2 antibody

CD121b / IL1R2 Mouse IgG2a 6G5 Purified Hu E
0.1 mg / €410.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

CD121b / IL1R2 Mouse IgG1 8.5 FITC Hu E, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

CD121b / IL1R2 Mouse IgG1 8.5 Purified Hu E, WB
0.1 mg / €410.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

AP07592PU-N CD121b/IL1R2 antibody staining of   Formalin-Fixed Paraffin-Embedded Human Small intestine, Peyer's patch at 10 µg/ml followed by biotinylated goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit Purified Hu E, ICC/IF, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

CD121b / IL1R2 Rabbit IgG Purified Hu E
0.1 mg / €390.00
  Acris Antibodies GmbH

CD121b / IL1R2 (Center) antibody

Western blot analysis in WiDr cell line lysates (35ug/lane) using CD121b / IL1R2 antibody Cat.-No. AP52192PU-N. This demonstrates the IL1R2 antibody detected the IL1R2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

CD121b / IL1R2 Mouse IgG1 49/20 Purified Hu E, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

CD121b / IL1R2 Rabbit Purified Hu E, F, IP
1 mg / €1,150.00
  Acris Antibodies GmbH

CD121b / IL1R2 antibody

CD121b / IL1R2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD121b / IL1R2 antibody

IL1R2 MaxPab rabbit polyclonal antibody. Western Blot analysis of IL1R2 expression in mouse kidney. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD121b / IL1R2 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between IL1A and IL1R2 HeLa cells were stained with anti-IL1A rabbit purified polyclonal 1:1200 and anti-IL1R2 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 1G12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD121b / IL1R2 antibody

Immunocytochemistry: IL1R2 Antibody (RM0013-11B7) [NB110-85472] - IL1R-II immunohistochemistry staining of paraffin sections of mouse Spleen and liver tissues from LPS exposed animals. Rat IgG2 RM0013-11B7 Purified Ms P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

CD121b / IL1R2 antibody

Immunohistochemistry: IL1R2 Antibody [NBP1-32681] - analysis of paraffin-embedded SW480 xenograft, using IL1R2(GTX108702) antibody at 1:100 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CD121b / IL1R2 antibody

CD121b / IL1R2 Mouse IgG1 8.5 FITC Hu E, F, WB
50 µg / €450.00
  Novus Biologicals Inc.

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