CD125 / IL5RA antibody

Principal name

CD125 / IL5RA antibody

Alternative names for CD125 / IL5RA antibody

Interleukin-5 receptor subunit alpha, IL-5R-alpha, IL5 Receptor alpha

SwissProt ID

P21183 (Mouse), Q01344 (Human)

Gene ID

3568 (IL5RA), 16192 (Il5ra)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of CD125 / IL5RA antibody

Interleukin 5 (IL-5) is a soluble T cell-derived factor, also known as T cellreplacing factor (TRF), that induces B cell and eosinophil growth and differentiation. IL-5 exerts its biological activity through the IL-5 receptor (IL-5R), which is composed of two chains: an alpha chain that binds IL-5 with low affinity and a beta chain that does not bind IL-5, but together with the IL-5 alpha chain, constitutes the high affinity IL-5 receptor. The cytoplasmic domain of both the alpha and beta chains is essential for signal transduction. Specifically, the membraneproximal proline-rich sequence of the cytoplasmic domain of the IL-5R receptor alpha subunit, IL-5Ralpha, is critical for the IL-5 induced proliferative response, expression of nuclear protooncogenes and tyrosine phosphorylation of cellular proteins, such as JAK1 and JAK2. Alternative splicing of the IL-5Ralpha gene produces several isoforms, including a membraneanchored isoform and a soluble isoform. The soluble isoform competes with IL-5 for binding to IL-5R and inhibits IL-5-mediated receptor activation and inflammatory mediator production, and, therefore, may be useful in treating asthma.

General readings

Bhattacharya M., et al. (2007) Biopolymers. 88:83-93.Emslie D., et al. (2008) J Exp Med. 205:409-421.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD125 / IL5RA antibody

Immunohistochemistry analysis of  CD125 / IL5RA Antibody Cat.-No. AP20672PU-N in Paraffin-Embedded Human pancreas tissue. Rabbit Aff - Purified Hu, Ms P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

IL5RA - human gene knockout kit via CRISPR

IL5RA - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

IL5RA - human gene knockout kit via CRISPR

IL5RA - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL5RA - human gene knockout kit via CRISPR

IL5RA - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

IL5RA - human gene knockout kit via CRISPR

IL5RA - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il5ra - mouse gene knockout kit via CRISPR

Il5ra - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Il5ra - mouse gene knockout kit via CRISPR

Il5ra - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il5ra - mouse gene knockout kit via CRISPR

Il5ra - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Il5ra - mouse gene knockout kit via CRISPR

Il5ra - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD125 / IL5RA (transcript variant 3)

  Recombinant protein of human interleukin 5 receptor, alpha (IL5RA), transcript variant 3  
CD125 / IL5RA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD125 / IL5RA (transcript variant 5)

  Purified recombinant protein of Homo sapiens interleukin 5 receptor, alpha (IL5RA), transcript variant 5  
CD125 / IL5RA Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CD125 / IL5RA (18-339, His-tag)

CD125 / IL5RA Mouse Purified > 90 % by SDS - PAGE
0.25 mg / €940.00
  Acris Antibodies GmbH

CD125 / IL5RA (18-339, His-tag)

CD125 / IL5RA Mouse Purified > 90 % by SDS - PAGE
50 µg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

IL5RA overexpression lysate

IL5RA overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

IL5RA overexpression lysate

IL5RA overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

IL5RA overexpression lysate

IL5RA overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, IL5RA (mGFP-tagged) - Human interleukin 5 receptor, alpha (IL5RA), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, IL5RA (mGFP-tagged) - Human interleukin 5 receptor, alpha (IL5RA), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €900.00
  OriGene Technologies, Inc.

Lenti ORF particles, IL5RA (mGFP-tagged)-Human interleukin 5 receptor, alpha (IL5RA), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, IL5RA (mGFP-tagged)-Human interleukin 5 receptor, alpha (IL5RA), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,010.00
  OriGene Technologies, Inc.

Lenti ORF particles, IL5RA (mGFP-tagged) - Human interleukin 5 receptor, alpha (IL5RA), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, IL5RA (mGFP-tagged) - Human interleukin 5 receptor, alpha (IL5RA), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €900.00
  OriGene Technologies, Inc.

Lenti ORF particles, IL5RA (mGFP-tagged) - Human interleukin 5 receptor, alpha (IL5RA), transcript variant 6, 200 uL, >10^7 TU/mL

Lenti ORF particles, IL5RA (mGFP-tagged) - Human interleukin 5 receptor, alpha (IL5RA), transcript variant 6, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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