CD126 / IL6R antibody

Principal name

CD126 / IL6R antibody

Alternative names for CD126 / IL6R antibody

Interleukin-6 receptor subunit alpha, IL-6R-alpha, IL-6R 1, IL6 Receptor alpha, Membrane glycoprotein 80

SwissProt ID

O18796 (Pig), P08887 (Human), P22272 (Mouse), P22273 (Rat)

Gene ID

3570 (IL6R), 16194 (Il6ra)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C), Functional assay (FN), ELISA (capture) (E(capture)), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD126 / IL6R antibody

IL6 exerts its activity through binding to a high affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa IL6 binding receptor protein (IL6R) and a 130 kDa signal transducing protein consisting of a 19 amino acid residue signal peptide (gp130). Human IL6R is a 468 amino acid residue type I membrane protein consisting of a 19 amino acid residue signal peptide, a 339 residue extracellular region, a 28 residue transmembrane region and an 82 residue cytoplasmic region. The ectodomain of IL6R is made up of an immunoglobulin like domain and a cytokine receptor superfamily domain. A naturally occurring soluble form of the IL6R, which binds IL6 and which mediates IL6 signaling through interaction with gp130, is identified in the urine of healthy adult humans. It has also been detected in human and mouse serum as well as in the conditioned medium of various cells including human peripheral blood mononuclear cells, and several T cell or granulocyte/macrophage cell lines. Increased expression of the c-fos and c-myc protooncogenes have been linked to IL6 receptor activation.

General readings

1. Clement C. et al, CR.3.2 Leucocyte Typing V, Boston, 1993
Kube D. et al., Blood, 2001; 98 : 762 - 770
2. Labbozzetta, M. et al.,Ann N Y Acad Sci.,2006; 1089: 268-75.
3. Lebeau, B. et al., FEBS Lett.,1997; 407(2): 141-7.
4. Mouthon, M. A. et al., Blood,1994; 84(4): 1085-97.
5. Muller-Newen, G. et al., Eur J Biochem.,1996; 236(3): 837-42.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD126 / IL6R antibody

  Rabbit anti-IL-6R Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using IL-6R antibody. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD126 / IL6R antibody

  IL6R mouse monoclonal antibody, clone OTI1B5 (formerly 1B5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL6R (RC221874, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL6R. Mouse IgG2a OTI1B5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD126 / IL6R antibody

  IL6R mouse monoclonal antibody, clone OTI2F4 (formerly 2F4)  
Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-IL6R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506859) Mouse IgG1 OTI2F4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD126 / IL6R antibody

A typical staining pattern with the B-F19 monoclonal antibody of U266 cell line Mouse IgG1 B-F19 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

A typical staining pattern with the B-N12 monoclonal antibody of U266 cell line Mouse IgG1 B-N12 Azide Free Hu E, F
0.2 mg / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-N12 FITC Hu E, F
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-N12 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-R6 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

A typical staining pattern with the B-R6 monoclonal antibody of U266 cell line Mouse IgG1 B-R6 Azide Free Hu C, F, FN, IP
0.2 mg / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

A typical staining pattern with the B-R6 monoclonal antibody of U266 cell line Mouse IgG1 B-R6 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-R6 Purified Hu C, F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CD126 / IL6R (Extracell. Dom.) antibody

CD126 / IL6R Rat IgG2 14F33 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

IL6R MaxPab polyclonal antibody. Western Blot analysis of IL6R expression in HeLa. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

IL6R MaxPab polyclonal antibody. Western Blot analysis of IL6R expression in HeLa. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

Western Blot analysis of IL6R expression in transfected 293T cell line (H00003570-T01) by IL6R MaxPab polyclonal antibody.

Lane 1: IL6R transfected lysate(51.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

Detection limit for recombinant GST tagged IL6R is approximately 0.1ng/ml as a capture antibody. Mouse IgG2b 2G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

Detection limit for recombinant GST tagged IL6R is approximately 0.3ng/ml as a capture antibody. Mouse IgG1 1E11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

CD126 / IL6R Goat Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

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