CD126 / IL6R antibody

Principal name

CD126 / IL6R antibody

Alternative names for CD126 / IL6R antibody

Interleukin-6 receptor subunit alpha, IL-6R-alpha, IL-6R 1, IL6 Receptor alpha, Membrane glycoprotein 80

SwissProt ID

O18796 (Pig), P08887 (Human), P22272 (Mouse), P22273 (Rat)

Gene ID

3570 (IL6R), 16194 (Il6ra)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Flow Cytometry (F), Paraffin Sections (P), ELISA (detection) (E(detection)), Neutralisation (NEUT), Functional assay (FN), ELISA (capture) (E(capture)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD126 / IL6R antibody

IL-6 is a multifunctional cytokine involved in the regulation of the immune response, hematopoiesis and acute phase response. It has been recognized to be a member of the alpha-helical cytokine family. IL-6 exerts its action via a cell surface receptor which consists of two subunits, an 80 kDa ligand binding subunit (gp80) of 468 amino acids and a 130 kDa signal transducing protein (gp130) of 896 amino acid residues. Characterisation of the extracellular portion of the 80 kDa IL-6 receptor revealed the existence of a single immunoglobulin-like domain in the NH2-terminal of the extracellular region, which does not contribute to ligand binding. The remainder of the extracellular domain however is essential for low affinity ligand binding, which consecutively triggers the association of the receptor and gp130 thus forming a high affinity binding site for IL-6. A soluble form of the human gp80 protein has been detected in serum and urine samples. This 55 kDa protein representing the extracellular portion of gp80 is generated by shedding, a process that seems to be controlled by protein kinase C. It is still functional, indicating that soluble gp80 plays a biological role in promoting IL-6 activity. So far, the soluble IL-6 receptor is unique in acting as an agonist together with its ligand.

General readings

1. Clement C. et al, CR.3.2 Leucocyte Typing V, Boston, 1993
Kube D. et al., Blood, 2001; 98 : 762 - 770
2. Labbozzetta, M. et al.,Ann N Y Acad Sci.,2006; 1089: 268-75.
3. Lebeau, B. et al., FEBS Lett.,1997; 407(2): 141-7.
4. Mouthon, M. A. et al., Blood,1994; 84(4): 1085-97.
5. Muller-Newen, G. et al., Eur J Biochem.,1996; 236(3): 837-42.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD126 / IL6R antibody

Western blot analysis of extracts of various cell lines, using IL-6R antibody. Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD126 / IL6R antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY IL6R (RC221874, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-IL6R. Mouse IgG2a OTI1B5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD126 / IL6R antibody

Immunohistochemical staining of paraffin-embedded Human lymph node tissue within the normal limits using anti-IL6R mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA506859) Mouse IgG1 OTI2F4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD126 / IL6R antibody

A typical staining pattern with the B-F19 monoclonal antibody of U266 cell line Mouse IgG1 B-F19 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

A typical staining pattern with the B-N12 monoclonal antibody of U266 cell line Mouse IgG1 B-N12 Azide Free Hu E, F
0.2 mg / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-N12 FITC Hu E, F
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-N12 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-R6 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

A typical staining pattern with the B-R6 monoclonal antibody of U266 cell line Mouse IgG1 B-R6 Azide Free Hu C, F, FN, IP
0.2 mg / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

A typical staining pattern with the B-R6 monoclonal antibody of U266 cell line Mouse IgG1 B-R6 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse IgG1 B-R6 Purified Hu C, F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CD126 / IL6R (Extracell. Dom.) antibody

CD126 / IL6R Rat IgG2 14F33 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CD126 / IL6R antibody

CD126 / IL6R Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

IL6R MaxPab polyclonal antibody. Western Blot analysis of IL6R expression in HeLa. Mouse Serum Hu E(detection), F, WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

IL6R MaxPab polyclonal antibody. Western Blot analysis of IL6R expression in HeLa. Mouse Purified Hu E(detection), F, WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

Western Blot analysis of IL6R expression in transfected 293T cell line (H00003570-T01) by IL6R MaxPab polyclonal antibody.

Lane 1: IL6R transfected lysate(51.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

Detection limit for recombinant GST tagged IL6R is approximately 0.1ng/ml as a capture antibody. Mouse IgG2b 2G6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

Detection limit for recombinant GST tagged IL6R is approximately 0.3ng/ml as a capture antibody. Mouse IgG1 1E11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CD126 / IL6R antibody

CD126 / IL6R Goat Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

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