CD13 antibody

Principal name

CD13 antibody

Alternative names for CD13 antibody

Aminopeptidase N, ANPEP, APN, PEPN, Alanyl aminopeptidase, Microsomal aminopeptidase, Aminopeptidase M, gp150, Myeloid plasma membrane glycoprotein CD13

SwissProt ID

P15144 (Human), P15145 (Pig), P15541 (Rabit), P15684 (Rat), P79098 (Bovin), P79143 (Canfa), P79171 (Felca), P97449 (Mouse)

Gene ID

290 (ANPEP), 16790 (Anpep), 404191, 81641

Available reactivities

Hu (Human), Prim (Primate), Ms (Mouse), Bov (Bovine), Mky (Monkey), Eq (Equine), Por (Porcine), Rb (Rabbit), Rt (Rat), Can (Canine), GP (Guinea Pig)

Available hosts

Mouse, Rat, Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Functional assay (FN), Immunoprecipitation (IP), Flow Cytometry (F), ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Dot blot (Dot), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CD13 antibody

The RNA recognition motif, also known as RNA binding motif, is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases. There is a second region towards the C terminus that has some features of a rrm but does not appear to have the important structural core of a rrm. The LA proteins are one of the main auto antigens in Systemic lupus. The APN2 protein was recently sequences under mammalian gene cloning project (MGC). This clone was sequences because it matches with the complete sequence of mRNA corresponding to gi: 7705400.
The APN2 (HDCMA18P) is a soluble protein with several structural motifs at the N-terminal end of the protein including a La protein interaction site and a strong RRM regions. The protein is also involves in signal transduction leading to malignant signals. The 77-79 kDa APN2 protein is generally express in detectable quantities in various cell lines and malignant tissues.

General readings

1. Bradstock, K.F. et al. (1985) Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells. Pathology. 17 (3): 392-9.
2. Bradstock, K.F. et al. (1985) Myeloid progenitor surface antigen identified by monoclonal antibody. Br J Haematol. 61 (1): 11-20.
3. Favaloro, E.J. et al. (1988) Further characterization of human myeloid antigens (gp160,95; gp150; gp67): investigation of epitopic heterogeneity and non-haemopoietic distribution using panels of monoclonal antibodies belonging to CD-11b, CD-13 and CD-33. Br J Haematol. 69 (2): 163-71.
4. Favaloro, E.J. (1991) CD-13 (gp150; aminopeptidase-N): co-expression on endothelial and haemopoietic cells with conservation of functional activity. Immunol Cell Biol. 69 ( Pt 4): 253-60.
5. Favaloro, E.J. et al. (1993) The hepatobiliary disease marker serum alanine aminopeptidase predominantly comprises an isoform of the haematological myeloid differentiation antigen and leukaemia marker CD-13/gp150. Clin Chim Acta. 220 (1): 81-90.
6. Favaloro, E.J. et al. (1993) CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated. Exp Hematol. 21 (13): 1695-701.
7. Tavoosidana, G. et al. (2011) Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Proc Natl Acad Sci U S A. 108: 8809-14.
8. Gredmark, S. et al. (2004) Human Cytomegalovirus Induces Inhibition of Macrophage Differentiation by Binding to Human Aminopeptidase N/CD13 J Immunol. 173: 4897-907
9. Grzywacz, B. et al. (2011) Natural killer-cell differentiation by myeloid progenitors. Blood. 117: 3548-58.
10. Stolzing, A. et al. (2008) Age-related changes in human bone marrow-derived mesenchymal stem cells: consequences for cell therapies. Mech Ageing Dev. 129: 163-73.
11. Silk, K.M. et al. (2012) Rapamycin conditioning of dendritic cells differentiated from human ES cells promotes a tolerogenic phenotype. J Biomed Biotechnol. 2012:172420.
12. Negussie, A.H. et al. (2010) Synthesis and in vitro evaluation of cyclic NGR peptide targeted thermally sensitive liposome. J Control Release. 143: 265-73.
13. Lassnig, C. et al. (2005) Development of a transgenic mouse model susceptible to human coronavirus 229E. Proc Natl Acad Sci U S A. 102 (23): 8275-80.
14. Thielitz, A. et al. (2004) Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation. Biochem Biophys Res Commun. 321 (4): 795-801.
15. McCormack, E. et al. (2013) Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia. Blood. 121 (7): e34-42.
16. Fiddler, C.A. et al. (2016) The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion. PLoS One. 11 (7): e0160108.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD13 antibody

Surface staining of human peripheral blood leukocytes with anti-CD13 mouse monoclonal antibody WM15. Mouse IgG1 WM15 Purified Hu, Prim C, E, F, FN, IP
0.1 mg / €220.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 FITC Ms F
0.1 mg / €270.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 FITC Ms F
50 µg / €270.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 FITC Ms F
25 µg / €190.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 FITC Ms F
0.5 mg / €560.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 Purified Ms C, F
0.25 mg / €390.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 Purified Ms C, F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 Purified Ms C, F
25 µg / €170.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 PE Ms F
100 Tests / €290.00
  Acris Antibodies GmbH

CD13 antibody

CD13 Rat IgG2a R3-63 PE Ms F
25 Tests / €210.00
  Acris Antibodies GmbH

CD13 antibody

Human kidney stained with anti-CD13 antibody. Rabbit IgG SP182 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD13 antibody

Western Blot analysis of U937 cell lysate with anti-CD13 antibody. Rabbit IgG SP187 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD13 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-ANPEP mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807395)(1:150) Mouse IgG2a OTI2E4 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD13 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-ANPEP mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA807396)(1:150) Mouse IgG2a OTI2F10 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD13 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-ANPEP mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807397)(1:150) Mouse IgG2a OTI3F8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CD13 antibody

Staining of Mouse Peripheral blood Granulocytes with Rat anti-Mouse CD13 antibody Cat.-No SM2298P Rat IgG2a ER-BMDM1 Purified Ms C, F
0.25 mg / €470.00
  Acris Antibodies GmbH

CD13 antibody

Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG1 Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human CD13 Purified (filled histogram) followed by Anti-Mouse IgG FITCand granulocyte (right) gates were used for analysis. Mouse WM-15 (WM15) Purified Hu F, P
0.1 mg / €120.00
  OriGene Technologies, Inc.

CD13 (79-91) antibody

TA329672 (1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD13 antibody

TA329673 (0.03ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD13 antibody

Western blot analysis of extracts of various cell lines, using ANPEP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

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