CD130 / IL6ST antibody

Principal name

CD130 / IL6ST antibody

Alternative names for CD130 / IL6ST antibody

Interleukin-6 receptor subunit beta, IL-6R-beta, IL6 receptor beta

SwissProt ID

P40189 (Human), P40190 (Rat), Q00560 (Mouse)

Gene ID

3572 (IL6ST), 16195

Available reactivities

Ms (Mouse), Hu (Human), Por (Porcine), Rt (Rat), Chk (Chicken), Mky (Monkey)

Available hosts

Goat, Rat, Mouse, Rabbit, Hamster

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Functional assay (FN), Immunoprecipitation (IP), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Neutralisation (NEUT)

Background of CD130 / IL6ST antibody

The KGP130 monoclol antibody reacts with mouse gp130, also known as CD130. gp130 is a 130 kD Type-I transmembrane glycoprotein containing a 597 amino acid extracellular domain, a single transmembrane domain, and a 277 amino acid cytoplasmic domain. gp130 is a subunit of several heterodimeric cell-surface receptors, including receptors for IL-6, IL-11, IL-27, Oncostatin M, and Leukemia Inhibitory Factor (LIF). The gp130 protein has also been found to exist in a soluble form, which is capable of inhibiting IL-6 sigling. gp130 is expressed mainly on T cells, monocytes, endothelial cells, activated B cells, and plasma cells, and is expressed at lower levels on most leukocytes and epithelial cells. In response to ligand binding, gp130 becomes tyrosine phosphorylated, leading to activation of several sigling pathways including the PI3 kise, Ras-MAPk and Stat pathways.Preincubation of mouse splenic T cells with IL-6 is capable of blocking the interaction of KGP130 with gp130, suggesting that the KGP130 binding site lies near the IL-6 interaction domain. Reactivity of KGP130 towards human gp130 has not been observed.

General readings

Saito M., et al. (1992) J Immunol. 148: 4066-4071.Murakami M., et al. (1993) Science. 260:1808-1810.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD130 / IL6ST antibody

A typical Flow Cytometry staining pattern of Eahy 926 cell line using  Cat. No. AM31176AF-N, clone B-P4. Mouse IgG1 B-P4 Azide Free Hu F, FN, IP, P, WB
0.2 mg / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

Staining of BALB/c splenocytes with Anti-Mouse CD3e FITC and 0.125 ug of Rat IgG2a kappa Isotype Control Purified (left) or 0.125 ug of Anti-Mouse CD130 Purified (right) followed by F(ab')2 Anti-Rat IgG PE .  Cells in the lymphocyte gate were used for analysis. Rat KGP130 Purified Ms F
25 µg / €150.00
  OriGene Technologies, Inc.

CD130 / IL6ST antibody

Western blot analysis of CD130/gp130 expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD130 / IL6ST antibody

Western blot analysis on Jurkat cell lysate using CD130/gp130 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD130 / IL6ST antibody

Western Blot: CD130 Antibody - was performed using affinity purified SEQer IL6ST antibody, aa(254-353) antibody. The lanes contain 5-30ug of a whole cell extract.  Final concentration of antibodies = 0.1ug/ml (1:10,000 dilution). The blot was probed overnight with the SEQer IL6ST antibody, aa(254-353) antibody.  Blot was then washed according to protocol and probed with goat-anti-Rabbit-HRP conjugate at 1:5000 dilution, washed and developed using chemiluminescence (film exposure 5-30sec).  The protein was detected as represented by the band shown. Rabbit IgG Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD130 / IL6ST antibody

Flow cytometric analysis of mouse CD130 expression on transfectant cells (right) and parental cells (left). Open histogram indicates the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26419AF-N to the cells. Hamster IgG HMb1 Azide Free Hu, Ms E, F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

CD130 / IL6ST Rat IgG2a RMb1 Aff - Purified Ms F
0.1 ml / €380.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

Flow cytometric analysis of mouse CD130 expression on transfectant (left) parental cells (right). Open histogram indicates the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26420RP-N to the cells. Rat IgG2a RMb1 PE Ms F
0.1 mg / €380.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-K5 monoclonal antibody of Eahy 926 cell line. Mouse IgG1 B-K5 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-P8 monoclonal antibody of Eahy 926 cell line. Mouse IgG1 B-P8 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-K11 monoclonal antibody of Eahy 926 cell line Mouse IgG2b B-K11 Azide Free Hu E, F, IP
0.2 mg / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-S12 monoclonal antibody of Eahy 926 cell line. Mouse IgG1 B-S12 Azide Free Hu F, FN, IP, WB
0.2 mg / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

CD130 / IL6ST Mouse IgG1 B-P4 Azide Free Hu E(capture)
1 mg / €790.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

CD130 / IL6ST Mouse IgG1 B-T2 Biotin Hu E(detection)
0.1 mg / €460.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-R3 monoclonal antibody of Eahy 926 cell line. Mouse IgG2a B-R3 Azide Free Hu F, FN
0.2 mg / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-R3 monoclonal antibody of Eahy 926 cell line. Mouse IgG2a B-R3 FITC Hu F
1ml (100T) / €270.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

A typical staining pattern with the B-R3 monoclonal antibody of Eahy 926 cell line. Mouse IgG2a B-R3 Purified Hu F
2ml (200T) / €250.00
  Acris Antibodies GmbH

CD130 / IL6ST antibody

Immunohistochemistry (IHC) analyzes of gp130 antibody (Cat.-No.: AP06506PU-N) in paraffin-embedded human breast tissue. Rabbit Aff - Purified Hu, Ms, Por ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CD130 / IL6ST pTyr905 antibody

Dot blot analysis of anti-Phospho-IL6ST-Y905 Phospho-specific Pab (AP17638PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml. Rabbit Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

CD130 / IL6ST (C-term) antibody

CD130 Antibody (C-term) (Cat. #AP50838PU-N)immunohistochemistry analysis in formalin fixed and paraffin embedded human uterus tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CD130 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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