CD132 / IL2RG antibody

Principal name

CD132 / IL2RG antibody

Alternative names for CD132 / IL2RG antibody

Gamma-C, p64, Interleukin-2 receptor gamma chain, Cytokine receptor common gamma chain

SwissProt ID

P31785 (Human), P34902 (Mouse), P40321 (Canfa), Q95118 (Bovin)

Gene ID

3561 (IL2RG), 16186 (Il2rg)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Neutralisation (NEUT)

Background of CD132 / IL2RG antibody

Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement. Mutation of IL2R gamma has been determined to be the cause of severe X-linked combined immunodeficiency (X SCID), a disease that is characterized by the absence of T cells and NK cells.

General readings

Ross, J.A., et al. J. Biol. Chem. 285(6):3582-3591(2010)
Ameratunga, R., et al. N. Z. Med. J. 122(1304):46-53(2009)
Clark, P.A., et al. Hum. Genet. 96(4):427-432(1995)
Ohbo, K., et al. J. Biol. Chem. 270(13):7479-7486(1995)
Bamborough, P., et al. Structure 2(9):839-851(1994)

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD132 / IL2RG antibody

Western blot analysis of extracts of Jurkat cell lines, using IL2RG antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CD132 / IL2RG (Center) antibody

Western blot analysis of CD132 / IL2RG Antibody (Center) Cat.-No AP52196PU-N in mouse brain tissue lysates (35ug/lane). IL2RG (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD132 / IL2RG (N-term) antibody

Western blot analysis of CD132 / IL2RG Antibody (N-term) Cat.-No AP52197PU-N in HL-60 cell line lysates (35ug/lane). IL2RG (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CD132 / IL2RG antibody

CD132 / IL2RG Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

CD132 / IL2RG antibody

Western Blot analysis of IL2RG expression in transfected 293T cell line (H00003561-T01) by IL2RG MaxPab polyclonal antibody.

Lane 1: IL2RG transfected lysate(40.59 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CD132 / IL2RG antibody

Western Blot analysis of IL2RG expression in transfected 293T cell line (H00003561-T02) by IL2RG MaxPab polyclonal antibody.

Lane 1: IL2RG transfected lysate(40.59 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CD132 / IL2RG antibody

Western Blot analysis of IL2RG expression in transfected 293T cell line (H00003561-T01) by IL2RG MaxPab polyclonal antibody.

Lane 1: IL2RG transfected lysate(42.30 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CD132 / IL2RG antibody

CD132 / IL2RG Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

CD132 / IL2RG antibody

CD132 / IL2RG Rat IgG2b TUGh4 Biotin Hu F
0.1 mg / €290.00
  Novus Biologicals Inc.

CD132 / IL2RG antibody

CD132 / IL2RG Rat IgG2b TUGh4 Biotin Hu F
25 µg / €160.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CD132 / IL2RG (23-262, His-tag)

CD132 / IL2RG Human Purified > 80 % by SDS - PAGE.
0.25 mg / €940.00
  Acris Antibodies GmbH

CD132 / IL2RG (23-262, His-tag)

CD132 / IL2RG Human Purified > 80 % by SDS - PAGE.
50 µg / €300.00
  Acris Antibodies GmbH

CD132 / IL2RG

CD132 / IL2RG Human
10 µg / €540.00
  Abnova Taiwan Corp.

CD132 / IL2RG

CD132 / IL2RG Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CD132 / IL2RG

CD132 / IL2RG Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

IL2RG 293T Cell Transient Overexpression Lysate(Denatured)

IL2RG 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

IL2RG overexpression lysate

IL2RG overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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