CD134 / TNFRSF4 antibody

Principal name

CD134 / TNFRSF4 antibody

Alternative names for CD134 / TNFRSF4 antibody

TNFRSF4, TXGP1L, ACT35 antigen, OX40L receptor,, Tumor necrosis factor receptor superfamily member 4, TAX transcriptionally-activated glycoprotein 1 receptor

Selected pictures

CD134 / TNFRSF4 antibody - SM055A
SM055A - Staining of stimulated rat spleen cells with RAT ANTI MOUSE CD134:AZIDE FREE
CD134 / TNFRSF4 antibody - SM055P
SM055P - Staining of Concanavalin A stimulated mouse spleen cells with Rat anti Mouse CD134

SwissProt ID

P47741 (Mouse), P15725 (Rat), P43489 (Human), A0S0B2 (Felca)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human), Fe (Feline)

Available hosts

Rat, Mouse, Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Western Blot (Tissue lysate) (WB-Ti), Immunofluorescence (IF)

Background of CD134 / TNFRSF4 antibody

Ox40 is a member of the tumor necrosis factor receptor (TNFR) family. It is a type I transmembrane protein expressed primarily on the surface of activated CD4+ T-cells. It is also expressed at low levels on the surface of activated CD8+ T cells, B cells, dendritic cells and eosinophils. Ox40 is a co-stimulatory molecule involved in T-cell activation and proliferation, the induction of cytokine production by effector T-cells, generation of memory T-cells, and arresting peripheral T-cell tolerance in vivo. Expression of Ox40 is induced following the initiation of a CD28 signal. It has been reported that the interaction of Ox40 with its ligand plays a role in the expansion of T-cell numbers at the height of the immune response as well as the generation of memory T-cells. Human Ox40 comprises a 186 amino acid extracellular domain containing four TNFR-Cys repeats, followed by a 21 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Ox40 activity is mediated by NF-kappaB signaling via interaction of the intracellular domain of Ox40 with TRAF proteins. Deregulated levels of Ox40 or an imbalance between Ox40 and Ox40L may result in T-cell mediated diseases especially allergic, inflammatory and autoimmune diseases. Additionally, Ox40 may also be important in the enhancement of anti-tumor responses. This is a HCX protein. HCX Expression System Details HCX proteins mimic the proteins in the human body because they are expressed from human, rather than animal, insect or bacterial cells. This process gives them human post-translational modifications. Recombinant DNA techniques allow a human protein with the correct amino acid sequence to be expressed in a non-human cell line. However, non-human cells lack the appropriate cellular machinery, such as specific glycosyltransferases, necessary to produce the correct human post-translational modifications of a protein. An extreme example is seen in E. coli cells, which produce recombinant proteins with no glycosylation, as the above figure illustrates. Rodent and yeast cells are able to glycosylate proteins, but they are still different from glycosylation in human cells. Expression System Resultant Proteins Human (e.g. K562, HEK293) Correct amino acid sequence Human post-translational modifications Rodent (e.g. CHO, NSO) Correct amino acid sequence Some natural glycosylation - not human-like Yeast (e.g. Pichia) Correct amino acid sequence Some natural glycosylation - not human-like E.Coli Correct amino acid sequence No PTMs Although there have been significant attempts to make non-human cell derived cytokines more human-like, there is a growing awareness that in many instances, particularly in therapeutics, cytokines should mimic those found in the body as closely as possible.

General references

Weinberg AD (2002) Trends Immunol. 23(2): 102-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CD134 / TNFRSF4 antibody

Immunofluorescence analysis of HeLa cells, using TNR4 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

CD134 / TNFRSF4 antibody

Lane1 - Feline CD134 expressing cells Lane2 - Control cells Lane3 - Recombinant feline CD134-Fc fusion protein (clone 7D6) used at 1µg/ml Mouse IgG1 7D6 FITC Fe, Hu F
0.1 mg / €430.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Mouse IgG1 7D6 Purified Fe F, WB
0.25 mg / €440.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Mouse IgG1 7D6 Purified Fe F, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody




Surface staining of human PHA-activated leukocytes with anti-human CD134 (Ber-ACT35) purified, GAM APC.


Mouse IgG1 Ber-ACT35 Purified Hu, Prim C, E, F, IP, P, WB
0.1 mg / €210.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

Surface staining of human PHA-activated leukocytes with anti-human CD134 (Ber-ACT35) purified, GAM APC. Mouse IgG1 Ber-ACT35 Hu, Prim F
100 Tests / €290.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Rat IgG1 OX-86 FITC Ms F
0.1 mg / €270.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Rat IgG1 OX-86 FITC Ms F
50 µg / €270.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Rat IgG1 OX-86 FITC Ms F
25 µg / €190.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Rat IgG1 OX-86 FITC Ms F
0.5 mg / €540.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

Staining of Concanavalin A stimulated mouse spleen cells with Rat anti Mouse CD134 Rat IgG1 OX-86 Purified Ms C, F
0.25 mg / €390.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Rat IgG1 OX-86 Purified Ms C, F
0.1 mg / €240.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Rat IgG1 OX-86 Purified Ms C, F
25 µg / €170.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

Staining of Concanavalin A stimulated mouse spleen cells with Rat anti Mouse CD134-RPE. Rat IgG1 OX-86 PE Ms F
100 Tests / €370.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

Staining of Concanavalin A stimulated mouse spleen cells with Rat anti Mouse CD134-RPE. Rat IgG1 OX-86 PE Ms F
25 Tests / €210.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Mouse IgG2b OX-40 Biotin Rt F
0.1 mg / €420.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

Staining of stimulated rat spleen cells with MOUSE ANTI RAT CD134:FITC (SM292F). Mouse IgG2b OX-40 FITC Rt F
0.1 mg / €430.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Mouse IgG2b OX-40 Purified Rt C, F
0.25 mg / €420.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Mouse IgG2b OX-40 Purified Rt C, F, IP
0.1 mg / €270.00
  Acris Antibodies GmbH

CD134 / TNFRSF4 antibody

CD134 / TNFRSF4 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

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